Cardiac electro-mechanical activity in a deforming human cardiac tissue: modeling, existence-uniqueness, finite element computation and application to multiple ischemic disease.

In this study, the cardiac electro-mechanical model in a deforming domain is taken with the addition of mechanical feedback and stretch-activated channel current coupled with the ten Tusscher human ventricular cell level model that results in a coupled PDE-ODE system. The existence and uniqueness of such a coupled system in a deforming domain is proved. At first, the existence of a solution is proved in the deformed domain.

Modeling and simulation of cardiac electric activity in a human cardiac tissue with multiple ischemic zones.

In this work, a human ventricular model (ten Tusscher and Panfilov model) coupled with the tissue level monodomain model is used to analyze the influence of multiple myocardial ischemia on the human cardiac tissue. The existence and uniqueness of the ischemic model comprising the monodomain model with a discontinuous ionic model for the human cardiac tissue is discussed. The coupled system of partial differential equation and ordinary differential equations are solved numerically using [Formula: see text] finite elements in space and Backward Euler finite difference scheme in time.