Pharmacokinetic interaction studies between felbamate and vigabatrin.

To assess the possible occurrence of pharmacokinetic interactions between the antiepileptic agents felbamate and vigabatrin, two randomized, double-blind, placebo-controlled, crossover studies were conducted in healthy male volunteers. In Study I, 18 subjects received oral vigabatrin 1000 mg every 12 h for two 8 days periods with felbamate 1200 mg every 12 h or placebo. In Study II, 18 other volunteers were administered oral felbamate 1200 mg every 12 h for two 8 days periods with vigabatrin 1000 mg every 12 h or placebo.

Visual accommodation as a cue for size.

Accommodation micropsia is examined in the general context of ocular accommodation as a cue for object size. The nature and limits of accommodation micropsia and arguments dealing with the possible contribution of accommodation to the perception of size are reviewed. Literature on the anomalous myopias, the intermediate-resting hypothesis, and theories of ciliary muscle innervation is examined critically in so far as it bears on the accommodation-micropsia hypothesis.

Controlling influence of phosphocitrate in vitro and in vivo on calcium oxalate crystal formation and growth.

Calcium oxalate (CaOx) crystallization in the presence of phosphocitrate (PC) was studied by both in vitro and in vivo techniques. Crystals of the monohydrate (COM) and the dihydrate (COD) forms were generated under controlled conditions in a silica gel matrix. Our data indicated only COD crystals formed when PC was present, inferring that the COD to COM transformation was being impeded.

Visual discrimination of pigmented skin lesions.

Three experiments explored human performance in discrimination of pigmented skin lesions from photographic slides. Experiment 1 showed that latent ability in identifying early melanoma was low, and some benign lesions tended to be falsely identified as serious. Performance overall did not decline when viewing time was reduced, suggesting that judgments could be made on the general appearance of lesions.

Skin examination for signs of cancer.

Doctors sometimes examine or suggest examination of the skin for signs of skin cancer, and self-examination of the skin has been promoted in some public education materials. A representative sample of 590 residents of Victoria was asked whether they or their doctors had ever deliberately checked for signs of skin cancer, and whether their doctors had ever suggested such a check. Respondents also indicated their skin type by degree of freckling and propensity to sunburn.

Effect of Helicobacter pylori eradication on peptic ulcer healing.

In a prospective study designed to assess the effect of Helicobacter pylori eradication on peptic ulcer healing, 85 consecutive patients with H. pylori-positive peptic ulcer disease were treated with a triple therapy regimen consisting of colloidal bismuth subcitrate 120 mg four times daily for 28 days, with metronidazole 400 mg three times daily and tetracycline 500 mg three times daily for the first seven days of treatment. H.

Pyomyositis in an adolescent female athlete.

A case of pyomyositis in a healthy 13-year-old female volleyball player is presented and discussed. This case is unusual because, historically, pyomyositis has been more common in males, especially those who participate in strenuous physical activity. However, competitive sports and vigorous exercise programs are becoming more widely available to young females.

Distribution of anti-CD68 (EBM11) immunoreactivity in formalin-fixed, paraffin-embedded bovine tissues.

A commercially acquired anti-human macrophage antibody (anti-CD68; EBM11) was used in an immunocytochemical technique to detect macrophages in formalin-fixed, paraffin-embedded tissues from cattle, pigs, humans, rats, turkeys, dogs, and cats. In healthy cattle, the antibody labeled alveolar macrophages, pulmonary intravascular cells (presumably intravascular macrophages), and macrophage-like cells in other tissues. In bovine lungs infected with Pasteurella haemolytica, EBM11 antibody labeled 95% of alveolar macrophages and macrophages within alveolar septa but only 0-2% of streaming or "oat" leukocytes.

Infected cell types in ovine lung following exposure to bovine respiratory syncytial virus.

Sixteen adult sheep (ten females, six males obtained from a closed flock at National Animal Disease Center, Ames, IA) were experimentally infected with bovine respiratory syncytial virus strain 375 (BRSV), and lung tissues were stained for viral antigen. Two infected sheep were euthanatized at each of the following post-inoculation times: 12, 24, 36, 48, 72, 96, 144, and 192 hours. Lung, nasal turbinates, trachea, right cranial bronchial and mediastinal lymph nodes, liver, and spleen were collected for histologic evaluation.

Pseudophakes experience apparent minification in an imaging display.

Apparent minification of virtual images has been attributed to accommodation micropsia, that is, a reduction in the apparent size of viewed objects accompanying an inward accommodation of the eyes. Thirteen bilateral pseudophakes incapable of accommodation but with good residual vision were tested monocularly for apparent minification in the viewfinder of a single-lens reflex camera. Apparent minification of about the same order as that typically found with normals occurred with the pseudophakic observers, demonstrating that pseudophakes are subject to distortions in apparent size with virtual-imaging displays in the same way as normals, thus establishing that visual accommodation is not a necessary condition for the effect.

Ventricular mitochondrial gene expression during development and following embryonic ethanol exposure.

The effects of chronic embryonic ethanol exposure were evaluated in chick ventricular muscle. Ethanol treatments were administered on embryonic days 11, 13, 15, and 17 and chicks were sacrificed at various time points following treatments. Fluctuations in embryonic blood ethanol levels were examined following treatments.

Apparent minification in an imaging display under reduced viewing conditions.

When extended outdoor scenes are imaged with magnification of 1 in optical, electronic, or computer-generated displays, scene features appear smaller and farther than in direct view. This has been shown to occur in various periscopic and camera-viewfinder displays outdoors in daylight. In four experiments it was found that apparent minification of the size of a planar object at a distance of 3-9 m indoors occurs in the viewfinder display of an SLR camera both in good light and in darkness with only the luminous object visible.

Apparent size and distance in an imaging display.

The size-distance invariance hypothesis suggests that the perceived size and the perceived distance of objects in a field viewed naturally are closely related. However, this relationship breaks down when scenes are viewed through high-power optical systems. When natural scenes are viewed through an imaging display of unity magnification, there is a reduction in their apparent size.