[Release of diltiazem chloride and ibuprofen from hydrophilic matrix tablets].

Hydrophilic matrix tablets based on hydroxypropylmethylcellulose (HPMC) and other cellulose derivatives rank among dosage forms with retarded effect widely used in contemporary pharmacotherapy. The active ingredient is released from them in dependence on its properties either by dissolution and diffusion, or erosion of the compact. The dissolution profile of the active ingredient can be influenced by variables of formulation and manufacture, e.

[Hydrophilic gel matrix tablets for oral administration of drugs].

Matrix tablets with a dispersed active ingredient are the simplest concept in the design of dosage forms with modified drug release. If they contain a swelling polymer as an auxiliary substance, the release from these systems, after initial liberation of a portion of the active ingredient from the surface, takes place by diffusion, erosion, or a combination of both mechanisms in dependence on the solubility of the contained active ingredient. Although hydrophilic matrix tablets have become a well-tried and widely used dosage form with retarded effects, their research continues and new auxiliary substances and their combinations are being tested.