Evaluation of the Anti-hypercholesterolemic Effect of Isolates From Various Sources.

The anti-hypercholesterolemic effect of 11 isolates was investigated by measuring remaining cholesterol in growth media, growth ability in media supplemented with cholesterol, and BSH activity. Among the selected isolates, DLBSH104, DLBSH122, and DLBSK207 have demonstrated outstanding potential as cholesterol-lowering cultures. The three isolates showed high cholesterol removal by growing cells, whereas resting and dead cells showed less cholesterol removal.

Genistein upregulates LDLR levels via JNK-mediated activation of SREBP-2.

Background: Genistein has been proved in vitro and in vivo to lower LDLR level. It is also widely consumed and implicated for its anti-atherogenic effects. However, the molecular mechanism by which genistein lowers the LDL level is still unknown.