Development of an automated artificial intelligence-based system for urogenital schistosomiasis diagnosis using digital image analysis techniques and a robotized microscope.

Background: Urogenital schistosomiasis is considered a Neglected Tropical Disease (NTD) by the World Health Organization (WHO). It is estimated to affect 150 million people worldwide, with a high relevance in resource-poor settings of the African continent. The gold-standard diagnosis is still direct observation of Schistosoma haematobium eggs in urine samples by optical microscopy.

Real-time PCR for malaria diagnosis and identification of Plasmodium species in febrile patients in Cubal, Angola.

Background: Malaria is the parasitic disease with the highest morbimortality worldwide. The World Health Organization (WHO) estimates that there were approximately 249 million cases in 2022, of which 3.4% were in Angola.

Usefulness of real-time PCR for urogenital schistosomiasis diagnosis in preschool children in a high-prevalence area in Angola.

Background: Urogenital schistosomiasis caused by Schistosoma haematobium is highly endemic in the municipality of Cubal in Angola. Currently, diagnosis is based on the observation of S. haematobium eggs in urine samples by microscopy but this method has low sensitivity.

An emission processing system for air quality modelling in the Mexico City metropolitan area: Evaluation and comparison of the MOBILE6.2-Mexico and MOVES-Mexico traffic emissions.

This article describes the High-Elective Resolution Modelling Emission System for Mexico (HERMES-Mex) model, an emission processing tool developed to transform the official Mexico City Metropolitan Area (MCMA) emission inventory into hourly, gridded (up to 1km) and speciated emissions used to drive mesoscale air quality simulations with the Community Multi-scale Air Quality (CMAQ) model. The methods and ancillary information used for the spatial and temporal disaggregation and speciation of the emissions are presented and discussed. The resulting emission system is evaluated, and a case study on CO, NO, O, VOC and PM concentrations is conducted to demonstrate its applicability.

The thirty gigahertz instrument receiver for the Q-U-I Joint Tenerife experiment: concept and experimental results.

This paper presents the analysis, design, and characterization of the thirty gigahertz instrument receiver developed for the Q-U-I Joint Tenerife experiment. The receiver is aimed to obtain polarization data of the cosmic microwave background radiation from the sky, obtaining the Q, U, and I Stokes parameters of the incoming signal simultaneously. A comprehensive analysis of the theory behind the proposed receiver is presented for a linearly polarized input signal, and the functionality tests have demonstrated adequate results in terms of Stokes parameters, which validate the concept of the receiver based on electronic phase switching.

Nonlinear forecasting measurement of magnetoencephalogram recordings from Alzheimer's disease patients.

The goal of this study was to analyze the magnetoencephalogram (MEG) background activity in patients with Alzheimer's disease (AD) using a nonlinear forecasting measure. It is a nonparametric method to quantify the predictability of time series. Five minutes of recording were acquired with a 148-channel whole-head magnetometer in 15 patients with probable AD and 15 elderly control subjects.

[Recommendations for antibiotic monitoring in ICU patients].

Monitoring plasma concentrations of antimicrobial agents used to treat infection in critically ill patients is one of the recommended strategies for improving clinical outcome. Drug monitoring has a double aim: to limit adverse events and to increase the effectiveness of the drugs. In clinical practice, however, this approach is mainly limited to monitoring plasma concentrations of vancomycin and aminoglycosides, although future extension to other antimicrobial agents would be desirable.

Use of the Higuchi's fractal dimension for the analysis of MEG recordings from Alzheimer's disease patients.

Alzheimer's disease (AD) is an irreversible brain disorder of unknown aetiology that gradually destroys brain cells and represents the most prevalent form of dementia in western countries. The main aim of this study was to analyse the magnetoencephalogram (MEG) background activity from 20 AD patients and 21 elderly control subjects using Higuchi's fractal dimension (HFD). This non-linear measure can be used to estimate the dimensional complexity of biomedical time series.

[Recommendations for antibiotic monitoring in ICU patients].

Unlabelled: Monitoring plasma concentrations of antimicrobial agents used to treat infection in critically ill patients is one of the recommended strategies for improving clinical outcome. Drug monitoring has a double

Aim: to limit adverse events and to increase the effectiveness of the drugs. In clinical practice, however, this approach is mainly limited to monitoring plasma concentrations of vancomycin and aminoglycosides, although future extension to other antimicrobial agents would be desirable.

Spring pollen and related allergies in southern Spain.

Over the last 10 years, there has been an increase in pollen allergies throughout Europe; this trend is clearly reflected in this study carried out in Córdoba (southern Spain) over 7 consecutive years, which recorded important increases in the concentrations of certain pollen types of particular interest in this city, together with an increase in the number of patients with pollinosis visiting the Allergy Unit at Córdoba's Reina Sofía University Hospital. The purpose of this study was to ascertain whether these two trends were related. Sampling was carried out from 1984 to 1990, using a Burkard spore trap placed at a height of approximately 15 m on a building situated in the city center.

Syndrome of inappropriate antidiuretic hormone secretion (SIADH) and enalapril.

A 69-year-old woman with a history of diabetes and hypertension, was referred to the Hospital of Laredo because of hyponatraemia. She had weakness and slight dyspnoea with no evidence of extracellular fluid volume depletion or oedema. Serum sodium level on admission was 125 mol l-1, plasma osmolality 270 mosmol kg-1, simultaneous urine osmolality was 580 mosmol kg-1 and urine sodium 32.

Differential respiratory patterns induced by opioids applied to the ventral medullary and dorsal pontine surfaces of cats.

The purpose of the present study was to make a functional dissection of the respiratory action of opioids, by their restricted application to the ventral surface of the medulla oblongata and to the rostro-dorsal surface of the pons in cats. The effects were compared to those induced after intracerebroventricular (i.c.

Participation of pontine structures in the respiratory action of opioids.

The respiratory action of morphine, D-Ala2-D-Leu5-enkephalin, and D-Ala2-Me-Phe4-Met(O)ol5-enkephalin, restrictively applied to the dorso-rostral surface of the pons, was studied in anesthetized cats. Frequency was selectively and dose-dependently depressed, down to apnea, whereas tidal volume and its response to CO2 either remained unchanged or were increased. Similar effects were observed in vagotomized and decerebrate cats.

Respiratory responses to opiates applied to the medullary ventral surface.

The participation of the medullary structures in the total respiratory effect of opiates was studied by restricting the access of the delta-agonist D-ala2-D-leu5-enkephalin and the mu-agonist D-ala2-Me-Phe4-Met (O) ol5-enkephalin, to the ventral medullary surface, and by comparing their responses with those induced after i.c.v.

Cardiovascular effects of intracerebroventricular injection of dopamine after selective MAO inhibition in rats.

Intracerebroventricular injection of dopamine (30-300 micrograms) caused a dose-dependent reduction in the blood pressure and cardiac rate of anaesthetized rats. Inhibition of MAO-type A with clorgyline enhanced the vasodepressant effect while it reversed the bradycardiac effect. Deprenyl, a MAO-type B inhibitor, did not modify the cardiovascular effects of dopamine injected into the cerebral ventricles.

Morphine, pentobarbital and naloxone in the ventral medullary chemosensitive areas: differential respiratory and cardiovascular effects.

Morphine, naloxone and pentobarbital were applied to ventral chemosensitive areas (M and S) and nonchemosensitive areas (pyramids) of the medulla oblongata in anesthetized cats. The respiratory and cardiovascular responses were studied. Morphine and pentobarbital caused a rapid respiratory depression when they were applied for 10 min to the areas M and S; they were inactive in the pyramidal area.

Respiratory effects of beta-endorphin, D-Ala2-met-enkephalinamide, and Met-enkephalin injected into the lateral ventricle and the pontomedullary subarachnoid space.

The respiratory effects of Met-enkephalin (900 microgram), D-Ala2-Met-enkephalinamide (10 microgram), and beta-endorphin (10 microgram) were studied and compared in lightly anesthetized cats, after injection into the lateral ventricle and into the pontomedullary subarachnoid space. The 3 peptides injected into the lateral ventricle induced equidepressant effects on respiration, but the duration of action and the involvement of either frequency or tidal volume varied considerably. Met-enkephalin was shorter-acting (45 min) than both D-Ala2-Met-enkephalinamide and beta-endorphin (over 5 h).

Inhibition of the activity of the respiratory and vasomotor centers by centrally administered 5-hydroxytryptamine in cats.

The influence of 5-hydroxytryptamine (5-HT) on the activity of the respiratory and vasomotor centers was studied by injecting 5-HT into the lateral and fourth ventricles of lightly anaesthetized cats. 50 and 500 mu g of 5-HT injected into the lateral ventricle induced a shortlasting increase in frequency and/or tidal volume followed by a prolonged and dose-dependent reduction of frequency, tidal volume and minute volume, concurrent with an increase in end expiratory CO2. The CO2 responsiveness of the respiratory center was depressed and the blood pressure levels were also lowered.