Publications by authors named "Mediannikov O"

The genus is composed of Gram-negative, fastidious, facultative intracellular bacteria that can cause bacteremia in mammals and various disorders in humans. Rodents have been reported as reservoirs of more than 30 species, seven of which cause zoonotic infections. In the present study, the isolation of sp.

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  • Acute respiratory infections are a major global health issue, and more research is needed on the microorganisms causing these infections in various regions, particularly in Senegal.
  • In a study of 500 febrile patients, researchers found that 73.2% had at least one detectable microorganism, with viruses and bacteria commonly identified, including influenza and RSV.
  • The presence of certain microorganisms was linked to respiratory symptoms, and co-infections were also associated with more severe symptoms, highlighting the need for better diagnostic tools to adapt treatment strategies.
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  • Treponematoses are chronic bacterial diseases primarily transmitted through sexual contact or direct interaction, but their epidemiology in wild primates remains largely unexplored due to the difficulty of studying these animals.
  • This study focused on critically endangered Western chimpanzees in Senegal, using a non-invasive stool serology method that revealed anti-treponemal antibodies in 13 out of 29 chimpanzees tested.
  • The findings highlight the importance of using non-invasive methods for disease surveillance in wildlife, emphasizing the need to assess and manage the risk of treponematosis within chimpanzee populations as part of a comprehensive One Health strategy.
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Background: With growing use of parasitological tests to detect malaria and decreasing incidence of the disease in Africa; it becomes necessary to increase the understanding of causes of non-malaria acute febrile illness (NMAFI) towards providing appropriate case management. This research investigates causes of NMAFI in pediatric out-patients in rural Guinea-Bissau.

Methods: Children 0-5 years presenting acute fever (≥38°) or history of fever, negative malaria rapid diagnostic test (mRDT) and no signs of specific disease were recruited at the out-patient clinic of 3 health facilities in Bafatá province during 54 consecutive weeks (dry and rainy season).

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  • Human lice, as specific ectoparasites of humans, transmit serious diseases like epidemic typhus, prompting the need for effective louse research methods.
  • The study developed a new rearing technique for Orlando (Or) body lice using artificial membranes, comparing two systems: the Hemotek feeding system and a Petri dish method.
  • Results showed that while blood anticoagulants influenced louse longevity and development, the Petri dish method with heparinized human blood allowed successful louse rearing, enabling further studies on pathogens and pesticides without compromising animal welfare.
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Termites are one of the most common pests that damage wood and other cellulosic materials Although Africa has more varieties of termite species than any other continent, few entomological studies have been conducted in Gabon. Identifying termites poses significant difficulties for entomologists. The aim of this study was to evaluate the reliability and confirm the significance of MALDI-TOF MS in identifying fresh termites collected in equatorial Africa.

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The composition of the vaginal microbiota is known to be influenced by various factors and to be associated with several disorders affecting women's health. Although metagenomics is currently a widely used method for studying the human microbiota, it has certain limitations, such as a lack of information on bacterial viability. It is therefore important to use culture-based methods such as culturomics.

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  • Sexually transmitted infections (STIs) are a significant global health issue, and while bacterial vaginosis (BV) isn't classified as an STI, it may heighten the risk of acquiring various STIs.
  • In a study with 290 women, those diagnosed with BV showed a higher prevalence of STIs (28%) compared to those without BV (20.4%); they also had more co-infections with multiple STI-causing microorganisms.
  • The findings suggest a potential link between BV and STIs, indicating more research is necessary to clarify this relationship and its implications for women's health.
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We describe a rare case of early Lyme borreliosis in France caused by Borrelia spielmanii, which manifested as a large erythema chronicum migrans rash. The patient completely recovered after a 15-day course of amoxicillin. Absence of pathognomonic signs prevented distinguishing B.

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Antibiotic resistance is a public health problem. The emergence of carbapenemase-producing Enterobacterales (CPE) infections is a concern, particularly in Senegal. (1) Methods: Between January 2019 and July 2022, 240 isolates of enterobacteria resistant to third-generation cephalosporins and imipenem from biological samples from Fann Hospital (Dakar) and Hôpital Paix (Ziguinchor) were selected.

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species are involved in various human diseases, causing a range of clinical manifestations; animals are considered as the main reservoirs, transmitting diverse species of through direct contact and haematophagous insects. Here, we characterize a new species, sp. nov.

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Zoonotic pathogens are responsible for most infectious diseases in humans, with rodents being important reservoir hosts for many of these microorganisms. Rodents, thus, pose a significant threat to public health. Previous studies in Senegal have shown that rodents harbour a diversity of microorganisms, including human pathogens.

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In Senegal, Coxiella burnetii, which causes Q fever, has often been identified in ticks and humans near livestock, which are considered to be reservoirs and main sources of infection. We describe the emergence of C. burnetii in rodents, not previously known to carry this pathogen, and describe 2 new genotypes.

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  • POC (Point-of-Care) laboratories have proven effective in managing pandemics such as COVID-19.
  • The spread of SARS-CoV-2 and its variants was exacerbated by population movements during major events.
  • The ongoing nature of the pandemic is linked to the virus's high mutation rate and the emergence of concerning variants, with POC labs in Senegal playing a key role in detecting these variants.
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Borrelia miyamotoi is a tick-borne zoonotic agent that causes hard tick-borne relapsing fever, an emerging disease in humans. Some small mammalian and bird species are reported to be reservoirs of B. miyamotoi.

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Wolbachia has an obligatory mutualistic relationship with many onchocercid nematodes of the subfamilies Dirofilariinae and Onchocercinae. Till date, no attempts have been made for the in vitro cultivation of this intracellular bacterium from the filarioid host. Hence, the current study attempted cell co-culture method using embryonic Drosophila S2 and the LD cell lines to cultivate Wolbachia from Dirofilaria immitis microfilariae (mfs) harvested from infected dogs.

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  • The study focused on a non-fermentative bacterium that shows natural resistance to colistin, an antibiotic, and has been found in both animals and humans, particularly after isolating six strains from Senegalese monkey stool.
  • Researchers tested various efflux pump inhibitors to see if they could decrease the bacterium's resistance to colistin; the combination of colistin and one specific inhibitor (CCCP) was effective in lowering the minimum inhibitory concentration, suggesting an efflux pump mechanism at work.
  • Further analysis indicated that certain efflux pumps (like YejABEF, NorM, and EmrAB) may play a role in this resistance, and the colistin-CCCP
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  • The study focuses on tick-transmitted bacteria in the genus Anaplasma, highlighting the discovery of new strains that are relevant to both veterinary and human health, especially in Senegal.
  • It reveals the introduction of Anaplasma turritanum and novel strains related to Anaplasma cinensis in ruminants, suggesting these should be classified under a new species called Anaplasma africanum.
  • The findings indicate a greater diversity of Anaplasma species than previously thought and emphasize the need for improved diagnostic methods and a One Health approach for better disease management in sub-Saharan Africa.
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  • Louse-borne trench fever, caused by Bartonella quintana, is a neglected health issue typically linked to body lice, but this study explores the potential role of head lice as a vector.
  • A local surveillance system in Senegal allowed researchers to track an outbreak from 2010 to 2015, collecting blood and head louse samples from patients to analyze for the bacteria.
  • The results revealed live B. quintana in head lice, with a significant percentage of both febrile and non-febrile patients carrying the bacteria, indicating that head lice can act as a vector for trench fever.
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Lice are host-specific insects. Human lice include Pediculus humanus (body lice) which are known to be vectors of serious human bacterial infectious diseases including epidemic typhus, relapsing fever, trench fever and plague; Pediculus humanus capitis (head lice) that frequently affect children; and Pthirus pubis, commonly known as crab lice. In Africa, human infections transmitted by lice remained poorly known and therefore, underestimated, perhaps due to the lack of diagnostic tools and professional knowledge.

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Equine filariosis (EF) is a neglected vector-borne disease caused by nematode species belonging to the Onchocercidae and Setariidae families. Aside from their zoonotic potential, some species are responsible for serious health problems in equids worldwide, leading to significant economic difficulties. Here, we molecularly investigated equine blood samples (320 horses and 109 donkeys from Egypt) and four adult worms isolated from the peritoneal cavity of 5 out of the 94 slaughtered donkeys.

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In the French region of Brittany, mainly in the department of the Côtes d'Armor, during the first half of 2021, seropositivity for SARS-CoV-2 was detected in five wild mustelids out of 33 animals tested (15.6%). Anti-SARS-CoV-2 IgG was detected against at least four out of five recombinant viral proteins (S1 receptor binding domain, nucleocapsid, S1 subunit, S2 subunit and spike) in three pine martens (Martes martes) and in two badgers (Meles meles) using the automated western blot technique.

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Background: Rickettsia felis is emergent in tropical areas. Despite its high morbidity, its natural history has not yet been fully determined. We investigated the role of the common household booklouse, Liposcelis bostrychophila, recently found to harbor R.

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Introduction: The role of wildlife in the transmission of antimicrobial resistant (AMR) is suspected but scarcely reported in current studies. Therefore, we studied the dynamics and prevalence of antibiotic-resistant in antibiotic-limited areas of Senegal.

Materials And Methods: We collected fecal samples from monkeys and apes (N = 226) and non-fecal environmental samples (N = 113) from Senegal in 2015 and 2019.

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