Publications by authors named "Medhat M El-Sebaie"
Article Synopsis
- The study investigates how mitochondrial DNA (mtDNA) genetic variations affect patients' responses to radiotherapy, particularly in the development of tissue fibrosis after treatment.* -
- In a group of 32 nasopharyngeal carcinoma patients, researchers found that those who were more sensitive to radiation had a higher number of nonsynonymous genetic variations and a specific variation (A10398G) linked to increased fibrosis risk.* -
- The results suggest that mtDNA variations play a significant role in radiation sensitivity and that these genetic factors should be considered alongside nuclear DNA variations when predicting patient responses to radiotherapy.*
Background: It has been hypothesized that patient to patient variation in normal tissue reactions to radiotherapy is associated with the presence of polymorphic variations in genes involved in DNA repair.
Purpose: To test for a possible association between two single-nucleotide polymorphisms (SNPs), XRCC1 399 G>A Arg/Gln and XRCC3 241 C>T Thr/Met and late reactions to radiotherapy.
Patients And Methods: In this case control study, 50 Head and Neck cancer patients were retrospectively recruited.
Predictors of outcome after radical cystectomy for bladder cancer in saudi patients; single institution experience.
J Egypt Natl Canc Inst
September 2004
Aim Of The Study: To evaluate different prognostic factors that may affect disease-specific survival in patients with bladder cancer following radical cystectomy.
Methods: Between July 1975 and December 2000, 229 patients underwent radical cystectomy and urinary diversion for bladder cancer in King Faisal Specialist Hospital and Research Center (KFSH & RC), Riyadh, Saudi Arabia. 175 patients had available records for review.
Objective: To assess natural history, treatment outcome and pattern of relapse in patients with maxillary sinus carcinoma.
Methods: A review was conducted of the medical records of all adult patients with maxillary sinus carcinoma, who were treated at King Faisal Hospital and Research Centre, Riyadh, Kingdom of Saudi Arabia, between January 1990 and December 1999. A total of 60 patients were identified for analysis, 36 men and 24 women; the median age was 58-years (range 23-95).