Suite of Biochemical and Cell-Based Assays for the Characterization of Kirsten Rat Sarcoma (KRAS) Inhibitors and Degraders.

KRAS is an important oncogenic driver which is mutated in numerous cancers. Recent advances in the selective targeting of KRAS mutants via small molecule inhibitors and targeted protein degraders have generated an increase in research activity in this area in recent years. As such, there is a need for new assay platforms to profile next generation inhibitors which improve on the potency and selectivity of existing drug candidates, while evading the emergence of resistance.

Eritrean pharmacists' job satisfaction and their attitude to re-professionalize pharmacy in to pharmaceutical care.

Objective: Job satisfaction is a very important contributing factor for a person's productivity and motivation. Naturally, if people are not satisfied with what they practice, they will probably need to change or reshape their way of practice at a certain period in time. Pharmacists are not exception to this principle and have been observed to re-professionalize pharmacy in to clinical and/or pharmaceutical care in many parts of the world.

Physicians' views on the professional roles of pharmacists in patient care in Eritrea.

Objective: A collaborative relationship between physicians and pharmacists is crucial in the patient oriented role of pharmacists. In order to get an optimal patient outcome, strong cooperation between pharmacists and physicians is necessary. It is evident that in patient-oriented activities of pharmacists, their roles should be appropriately perceived and welcomed by physicians.