Publications by authors named "Meddy N Bongers-Karmaoui"
Article Synopsis
- Overweight and obesity are significant risk factors for cardiovascular diseases, and this study aimed to investigate the impaired cardiovascular response to exercise in children with these conditions.
- The research involved a comparison between 41 overweight/obese children and 166 normal-weight children, monitoring continuous heart rate and blood pressure during stress tests.
- Results showed that higher BMI linked to elevated resting blood pressure and a reduced ability to increase blood pressure during exercise, suggesting potential cardiovascular dysfunction in overweight and obese youth.
To examine feasibility and reproducibility and to evaluate the cardiovascular response to an isometric handgrip exercise in low-risk pediatric population using Cardiovascular Magnetic Resonance measurements. In a subgroup of 207 children with a mean age of 16 years participating in a population-based prospective cohort study, children performed an isometric handgrip exercise. During rest and exercise, continuous heart rate and blood pressure were measured.
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- The study aimed to examine the impact of gestational hypertensive disorders and maternal blood pressure on the heart structure and function of children during childhood.
- Conducted in Rotterdam, the population-based cohort study involved 2502 mother-offspring pairs, measuring maternal blood pressure at various pregnancy stages and assessing children's cardiac health at age 10 using advanced imaging techniques.
- Results indicated that while pre-eclampsia was linked to lower right ventricular function in children, higher maternal diastolic blood pressure was correlated with reduced heart sizes, highlighting the importance of maternal health on offspring cardiac development, without significant links to paternal blood pressure.
Aim: To examine whether maternal angiogenic factors in the first half of pregnancy are associated with offspring left and right cardiac development.
Methods: In a population-based prospective cohort among 2,415 women and their offspring, maternal first and second trimester plasma PlGF and sFlt-1 concentrations were measured. Cardiac MRI was performed in their offspring at 10 years.
Background And Aims: Reduced maternal placental growth factor (PlGF) and higher soluble fms-like tyrosine kinase (sFlt-1) concentrations in pregnancy may have persistent effects on offspring vasculature. We hypothesized that suboptimal maternal angiogenic factors in pregnancy may adversely affect fetal vascular development, leading to an increased risk of adverse atheriosclerotic adaptations and higher blood pressure in offspring.
Methods: In a population-based prospective cohort among 4565 women and their offspring, we examined the associations of maternal serum PlGF and sFlt-1 concentrations in the first half of pregnancy with offspring vascular development.
Stress inducement by physical exercise requires major cardiovascular adaptations in both adults and children to maintain an adequate perfusion of the body. As physical exercise causes a stress situation for the cardiovascular system, cardiovascular exercise stress tests are widely used in clinical practice to reveal subtle cardiovascular pathology in adult and childhood populations with cardiac and cardiovascular diseases. Recently, evidence from small studies suggests that the cardiovascular stress response can also be used within research settings to provide novel insights on subtle differences in cardiovascular health in non-diseased adults and children, as even among healthy populations an abnormal response to physical exercise is associated with an increased risk of cardiovascular diseases.
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