Publications by authors named "Meckes J"
The role of stress in altering fear memory is not well understood. Since individual variations in stress reactivity exist, and stress alters fear memory, exposing individuals with differing stress-reactivity to repeated stress would affect their fear memory to various degrees. We explored this question using the average stress-reactive Fisher 344 (F344) rat strain and the Wistar-Kyoto (WKY) strain with its heightened stress-reactivity.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates individual differences in acute stress responsiveness, primarily using Fischer 344 (F344) and Wistar Kyoto (WKY) rat strains known for their contrasting stress behaviors.
- A specific region on chromosome 6, identified as Stresp10, was analyzed for genetic variations that may contribute to these behavioral differences through gene expression studies in key brain areas.
- The creation of a congenic strain combining genetic material from WKY and F344 at the Stresp10 region linked certain genes, like Gpatch11 and Cdkl4, to behavioral traits associated with stress responsiveness, suggesting they may be important in understanding this variation.
Heterogeneous stock rats: a model to study the genetics of despair-like behavior in adolescence.
Genes Brain Behav
February 2018
Major depressive disorder (MDD) is a complex illness caused by both genetic and environmental factors. Antidepressant resistance also has a genetic component. To date, however, very few genes have been identified for major depression or antidepressant resistance.
View Article and Find Full Text PDFCompromised autophagy precedes meniscus degeneration and cartilage damage in mice.
Osteoarthritis Cartilage
November 2017
Objective: Autophagy is a cellular homeostasis mechanism that facilitates normal cell function and survival. Objectives of this study were to determine associations between autophagic responses with meniscus injury, joint aging, and osteoarthritis (OA), and to establish the temporal relationship with structural changes in menisci and cartilage.
Methods: Constitutive activation of autophagy during aging was measured in GFP-LC3 transgenic reporter mice between 6 and 30 months.