Thromboelastography in term neonates: an alternative approach to evaluating coagulopathy.

Objective: To develop normative ranges for citrate-modified and heparinase-modified thromboelastography (TEG) in term neonates.

Design: Prospective observational study.

Setting: An outborn neonatal and cardiac intensive care unit in a free-standing academic children's hospital.

Effect of temperature on thromboelastography and implications for clinical use in newborns undergoing therapeutic hypothermia.

Background: Encephalopathic neonates undergoing therapeutic hypothermia have increased risk for coagulopathy secondary to perinatal asphyxia and effects of cooling on the coagulation enzyme cascade. Thromboelastography (TEG) allows for a comprehensive assessment of coagulation that can be regulated for temperature. TEG has not been previously evaluated in newborns undergoing hypothermia treatment.