Publications by authors named "Meagan Todd"
Pre-clinical investigation of liquid sirolimus for local drug delivery.
Front Cardiovasc Med
September 2023
Article Synopsis
- Sirolimus is being researched as a potential alternative to paclitaxel for treating peripheral artery disease (PAD), focusing on its delivery in liquid form rather than its traditional use in stent coatings.
- The pilot study assessed the feasibility of delivering liquid sirolimus using four drug delivery devices in a porcine artery model, measuring drug penetration and retention with advanced imaging and chromatography techniques.
- Results showed that the Occlusion Perfusion Catheter (OPC) provided the deepest drug penetration and successfully delivered liquid sirolimus at both 1 and 24 hours, indicating promising potential for this approach in PAD treatment.
Objective: Local Liquid drug (LLD) delivery devices have recently emerged as a novel approach to treat peripheral arterial disease. This systemic review aims to identify and evaluate the clinical utility of the most commonly used delivery devices.
Methods: A systemic review was performed using the Medical Subjects Heading terms of "drug delivery," "liquid," "local," and "cardiovascular disease" in PubMed, Google Scholar, and Scopus.
Understanding the Mechanism of Drug Transfer and Retention of Drug-Coated Balloons.
J Cardiovasc Pharmacol Ther
August 2022
Objective: The purpose of this study was to determine the impact of varying inflation parameters on paclitaxel delivery and retention using a commercially available DCB.
Background: Drug-coated balloons (DCB) have become the standard treatment for peripheral artery disease. Clinical data suggest that varying DCB delivery parameters directly impact patient outcome.