Publications by authors named "Meagan A Johnson"
Article Synopsis
- A quality improvement project aimed to reduce unnecessary blood tests and antibiotics for infants exposed to chorioamnionitis by using the Kaiser Sepsis Calculator (KSC) at a Texas health facility.
- After implementing the KSC, testing rates for complete blood counts (CBC) decreased significantly from 96% to 27%, and blood cultures (BCx) from 98% to 37%.
- The program successfully lowered antibiotic use from 25% to 16%, without missing any cases of early onset sepsis, demonstrating the effectiveness of a nurse-led approach to improve care for these infants.
Background: Modafinil and its enantiomer R-modafinil are approved for the treatment of various sleep disorders, and may also be efficacious in the treatment of psychostimulant abuse. However, the ability of modafinil and R-modafinil to alter brain reward function has not yet been assessed.
Purpose: This study assessed the effects of modafinil and R-modafinil on brain reward function using the intracranial self-stimulation (ICSS) paradigm.
Pharmacological manipulation of the type 5 metabotropic glutamate (mGlu5) receptor alters various addiction related behaviors such as drug self-administration and the extinction and reinstatement of drug-seeking behavior. However, the effects of pharmacological modulation of mGlu5 receptors on brain reward function have not been widely investigated. We examined the effects of acute administration of positive and negative allosteric modulators (PAMs and NAMs, respectively) on brain reward function by assessing thresholds for intracranial self-stimulation (ICSS).
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