Vaginal discharge concentrations of β-human chorionic gonadotropin, creatinine, and urea for the diagnosis of premature rupture of membranes.

Objective: To determine the diagnostic value of vaginal discharge concentrations of β human chorionic gonadotropin (β-hCG), creatinine, and urea to identify premature rupture of membranes (PROM).

Methods: An observational cross-sectional study was conducted between 12 June, 2014, and 11 June, 2015, among 120 women who were admitted to an Iranian hospital at 28-41 weeks of pregnancy. Women with positive pooling and nitrazine test results were assigned to the PROM group (n=60), whereas those with negative test results were assigned to the control group (n=60).