Peculiarities of the development of analgesic effect during transcutaneous dynamic electrical stimulation.

The effect of transcutaneous dynamic electrical neurostimulation on the development of analgesia was studied in behavioral and electrophysiological experiments on rats. A 30-min dynamic electrical stimulation elevated the nociception threshold in tail-flick and hot plate tests, increased the threshold of the late nociceptive flexor reflex, and decreased the number of bursts in the response. Intraperitoneal injection of naloxone (2 mg/kg) abolished the analgesic effect of dynamic electrical neurostimulation.

Effect of bioresonance therapy on antioxidant system in lymphocytes in patients with rheumatoid arthritis.

We measured activities of superoxide dismutase, catalase, and glutathione peroxidase and content of nonprotein thiol groups (reduced glutathione) in blood lymphocytes from patients with rheumatoid arthritis before and during bioresonance therapy. The state of the antioxidant system in lymphocyte from patients receiving standard pharmacotherapy was characterized by activation of the key antioxidant enzymes and decreased content of thiol groups. Bioresonance therapy increased the content of thiol groups and normalized activities of superoxide dismutase and glutathione peroxidase.

[Neurophysiological analysis of analgesic effect of phentanyl and moradol].

The central mechanisms of analgesic action of phentanyl and moradol are compared using analysis of changes in the early and late components of somatosensory evoked potentials (SSEP) of the brain in normal volunteers in response to pain stimulation. Phentanyl and moradol differently affect the changes in the early components of SSEP: phentanyl reduces their amplitude, whereas moradol increases it. Both drugs similarly influenced changes in the late components of SSEP.

[Multimodal evoked potentials and central mechanisms of afferentation in trigeminal neuralgia].

Multimodal evoked potentials in patients with trigeminal neuralgia are analyzed in the paper. The comprehensive studies of cortical trigeminal somatosensory evoked potentials, visual evoked potentials, and brainstem auditory evoked potentials have revealed their changes that are indicative of the impaired central mechanisms of afferentation in patients with trigeminal abnormality. The findings are discussed in the light of the theory of generator mechanisms of neuropathological pain syndromes.

[A neurophysiological analysis of the sensory disorders in trigeminal nerve neuropathy].

52 patients with various types of trigeminal nerve neuropathy were examined in terms of trigeminal somatosensory evoked potentials (TSEP). The increase of latent periods and the decrease of N5-N33 amplitude components as well as disappearance of some separate components of this period were observed in patients with moderate facial pain and hypersthesia when sore side was stimulated. Meanwhile the alterations level of TSEP correlated with trigeminal hypesthesia severity.

[The dynamic clinico-physiological indices of sexual function during the management of vertebrogenic pain syndromes].

Sexual changes were registered electrophysiologically in 52 patients with low back pain of vertebrogenic origin. M-response of the bulbocavernous muscle emerged at low threshold. There were shifts in the latency and amplitude of the somatosensory evoked potentials of the brain.

[Neurophysiologic analysis of the effects of the centrally acting analgesics moradol, tramal and nubain].

The analysis of measurements of early and late components of somatosensory (SSEP) and visual evoked potentials (VEP) in healthy examinees was used to compare the central mechanisms responsible for the analgesic action of moradol, tramal, and nubain. As compared to tramal and nubain, moradol was found to cause a more profound increase in the amplitude of early SSEP components. With this, all three agents were equal in suppressing the amplitude of late SSEP and VEP components.

[An analysis of the analgesic action of electroacupuncture].

The analgetic effect of electroacupuncture (EAP) was assessed by changes in subjective feelings, amplitude of somatosensory evoked potentials (SSEP) and testing of monosynaptic transmission of spinal neurons. Following EAP changes in psychophysical and psychological characteristics of stimulation perception in healthy subjects corresponded to a decrease in late SSEP components, threshold of H-reflex appearance and maximum amplitude, which was not observed in patients before surgery. Changes in subjective sensitivity registered in the latter patients did not significantly differ from baseline values and were of opposite direction, which presupposes obligatory combination of EAP with the use of psychoactive drugs during preparation for surgery.

[Somatosensory evoked potentials in patients with lesions of the trigeminal nerve system].

These are results of comparison of clinical data and parameters of early components of somatosensory evoked potentials (SSEP) in patients with various pathological disorders in the trigeminal nerve system. The investigations evidenced that neurologic patients have different degrees of disorders in structural-functional organization of trigeminal nerve system resulting from the disease itself and previous therapeutic interventions. Some of the peculiarities of SSEP changes, e.

[Neural regulation of heart function in the Pteropod mollusc Clione limacina].

The heart of the pteropodial mollusc Clione limacina is innervated by the median nerve arising from the left abdominal ganglion. Five neurons sending axons to the heart have been identified in the Clione central nervous system with retrograde cobalt or Lucifer yellow staining. Neuron H1 located in the left pedal ganglion evoked heart excitation.

[Neuronal mechanisms of the generation of the feeding rhythm in the buccal ganglia of the pteropod mollusk].

Two antagonistic groups of neurons, active in protractor and retractor phases of the feeding cycle, were found in the buccal ganglia of the pteropod mollusc Clione limacina. Neurons within each group are electrically coupled, while the groups inhibit one another. Each group is able to perform independent rhythmic activity.

Control of feeding movements in the freshwater snail Planorbis corneus. I. Rhythmical neurons of buccal ganglia.

(1) The buccal mass of the freshwater snail Planorbis corneus, dissected together with the buccal ganglia, performs rhythmic feeding movements. Radula movements and the electrical activity in various nerves of buccal ganglia were recorded in such a preparation. The cycle of radula movements consisted of three phases: quiescence (Q), protraction (P) and retraction (R).

[Functional architectonics of neuronal antinociceptive mechanisms during the electroacupuncture method of reflex action].

The peculiarities of neurone bioelectric activity of sensory thalamic nuclei under electroacupuncture (EAP) stimulation have been studied in acute experiments on cats. EAP stimulation has been established to change spontaneous and evoked activity of neurones of sensory thalamic nuclei, that testifies to the development of a new functional state. The functional state of the cortex, in particular the second somatosensory region has been shown to determine the nature of neurone activation of sensory thalamic nuclei during the EAP stimulation.

[Somatosensory evoked potentials and their dynamics among trigeminal neuralgia patients during reflexotherapy].

The study of somatosensory evoked potentials (SSEP) in patients with trigeminal neuralgia made it possible to elucidate their characteristic changes as compared to those in healthy subjects. After a course of acupuncture 75% of the patients showed correlation between some parameters of SSEP and positive clinical results. The authors discuss pathophysiological mechanisms of impairment of cortico-subcortical interactions in patients with trigeminal neuralgia and analyze the possibility of using SSEP for dynamic evaluation of the brain status in the process of treatment.

[Proportion of short propriospinal fibers in the lumbar division of the spinal cord of the cat].

Stimulating and recording electrodes were located at various distances from each other either in the lateral or in the ventral funiculus of the lumbar spinal cord of decerebrated curarized cats. The recorded response considerably decreased at the distance of 10-15 mm, suggesting that most propriospinal fibres have a length not exceeding the length of one or two spinal segments.

[Activity of propriospinal neurons of segments C3 and C4 during "fictive locomotion" in the cat].

The activity of C3-C4 propriospinal neurons was recorded during "fictitious locomotion" of forelimbs in immobilized decerebrated cats with the spinal cord transected at the lower thoracal level. The neurons were identified by the antidromic responses to stimulation of the lateral funiculus in the C6 segment. Most of the neurons (70%) were antidromically activated also from the lateral reticular nucleus.

Cortical projections to the periaqueductal grey in the cat: a retrograde horseradish peroxidase study.

Stereotaxic fluid microinjections of horseradish peroxidase into different parts of the rostral and caudal periaqueductal grey (PAG) in cats have provided substantial retrograde evidence that the somatosensory cortex (I and II), frontal cortex, insular and cingular cortex are the principal sources of cortical-PAG projections. The somatosensory cortex II projects to all the regions of the rostral and caudal PAG. The frontal cortex projects to dorso-lateral quadrant of the PAG.

[Corticofugal projections to the periaqueductal gray matter in the cat midbrain].

Stereotaxic microinjections of horseradish peroxidase (HP) were made into different parts of the rostral and caudal periaqueductal gray (PAG) in cats to study corticofugal projections to the PAG. The method of retrograde axonal transport of HP demonstrated labeled neurons in the I and II somatosensory areas, frontal, cingular and insular cortex of the brain. It was shown that the II somatosensory cortex projects to all the areas of the rostral and caudal PAG.