Publications by authors named "Meĭsner I"

Aims: To evaluate the accuracy of sonographic estimation of fetal weight (EFW) in diabetic pregnancies and pregnancies with suspected fetal macrosomia.

Methods: 63 women with diabetic pregnancies, 74 nondiabetic women with suspected large-for-gestational-age (LGA) infants, and 161 controls underwent ultrasound assessment prior to induction of labor. EFW was compared to the weight at birth, 1-3 days later.

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The investigation of microkinetics of 90Sr, 137Cs and 32P penetration into erythrocytes of dog's blood was made. It was shown that processes of penetration of 90Sr and 32P are monomolecular. The slow stage is monomolecular destruction of complexes of 90Sr and 32P with plasma components.

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Decreased 2-deoxyglucose (2-DOG) uptake is well described in the neutrophils of patients with glycogen storage disease type 1b (GSD 1b). We report a patient with GSD 1b who presented with a normal antenatal and perinatal 2-deoxyglucose uptake that showed a slow regression during the first months of life. These indicate limitations of 2-deoxyglucose uptake in the diagnosis of GSD 1b.

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During development of transmitted solid hepatoma 22 pools of purine metabolites were studied as well as the rate of 3H-hypoxanthine and inosine incorporation was measured in acid soluble fraction of liver tissue and erythrocytes of mice C3HA as well as of the tumor tissue. Specific alterations in metabolism of adenine and guanine nucleotides and of their derivatives were detected at various steps of the hepatoma development in the tissues studied. Specific interaction of the hepatoma cells with host tissues appears to be realized via the pool of purine nucleotides.

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Article Synopsis
  • The use of ion-air reagents in reversed-phase chromatography helps separate purine and pyrimidine derivatives effectively.
  • Simultaneous analysis of nucleotides, nucleosides, and their bases was performed using an acetonitrile gradient and tetrabutyl ammonium phosphate as a counterion.
  • Optimal conditions for the isocratic separation of adenine nucleotides and metabolic products were established, along with modifications to separate specific purines and pyrimidines.
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Simultaneous separation of the main ribonucleotides, nucleosides and bases was carried out using tetrabutyl ammonium phosphate (TBA) hetaerons with a reversed-phase (C18) packing material. Chromatographic properties of purine and pyrimidine metabolites in radially compressed NovaPak C18 system was studied at various concentrations of acetonitrile and TBA in the mobile phase. The optimal conditions for gradient separation of nucleotides, nucleosides and bases were evaluated.

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A method is described for the simultaneous analysis of twelve major nucleotides, certain biochemically essential nucleosides and nitrogen bases. The separation was achieved using an ion-pair reversed-phase high-performance liquid chromatographic (HPLC) system with a radially compressed NovaPak C18 cartridge and tetrabutylammonium phosphate (TBA) as a mobile phase modifier under acetonitrile gradient conditions. The effects of TBA and acetonitrile on the retention of major nucleotides were studied.

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The authors explored the statics of Ca2+ and Sr2+ sorption from a saline, imitating the salt (mineral) composition of the blood plasma, and from blood plasma. As the plasma concentration was raised, there was a consistent decrease in ion sorption of KU = 2 X 8 cationite characteristic for M2+ complex formation in solution. Conventional constants for formation of complex compounds and mole proportions (%) of free (M2+) and complex forms (MLx-) metals were calculated.

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A case of hypernephroma is presented in which the initial finding was heavy bleeding from a vaginal tumor. Fewer than 90 cases of genital metastases in males or females have previously been reported.

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A method of cation metabolism on cationite KY=2X8 in the balanced-salt form was applied to the study of sorption of Mg2+, Ca2+ and Sr2+ ions from physiological solutions and solutions containing blood plasma of dogs and physiological saline in different ratio. Balance constants, which permitted to determine mol fractions (or the content percentage), of "free" and "bound" ions of the corresponding metals were calculated from the experiments.

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