Unveiling nature's antidiabetic potential in Berberis orthobotrys seeds for alloxan-induced diabetic rats.

To illustrate the anti-diabetic properties of Berberis orthobotrys seeds was the aim of the current study. After a series of experiments, two doses of aqueous methanolic extract of the seeds were selected i.e.

Micronutrient dose response (MiNDR) study among women of reproductive age and pregnant women in rural Bangladesh: study protocol for double-blind, randomised, controlled trials.

Introduction: Optimising the micronutrient status of women before and during reproduction confers benefits to them and their offspring. Antenatal multiple micronutrient supplements (MMS), given as a daily tablet with nutrients at ~1 recommended dietary allowance (RDA) or adequate intake (AI) reduces adverse birth outcomes. However, at this dosage, MMS may not fully address micronutrient deficiencies in settings with chronically inadequate diets and infection.

The impact of maternal mindful parenting on preschoolers' emotional regulation abilities: The mediating role of depression and the moderating role of the parent-child relationship.

Purpose: An examination into the effects of maternal variables on children's emotional regulation abilities, as well as the processes that underlie these effects, may improve our ability to effectively promote the development of children's emotional regulation ability. This study looks at how maternal depression influences the relationship between mindful parenting and children's emotional regulation ability. It also investigates the potential moderating effects of the parent-child relationship.

Informative censoring in externally controlled clinical trials: a potential source of bias.

Background: Cancer researchers frequently consider the use of single-arm and randomized controlled clinical trial designs that leverage external data. The literature has reported extensively on how the use of external data can introduce bias through a variety of distortion mechanisms. In this article, we focus on a distortion mechanism that is often overlooked: informative censoring.

Molecular and computational analysis of a novel pathogenic variant in emopamil-binding protein (EBP) involved in cholesterol biosynthetic pathway causing a rare male EBP disorder with neurologic defects (MEND syndrome).

Background: Male EBP disorder with neurologic defects (MEND syndrome) is an extremely rare disorder with a prevalence of less than 1/1,000,000 individuals worldwide. It is inherited as an X-linked recessive disorder caused by impaired sterol biosynthesis due to nonmosaic hypomorphic EBP variants. MEND syndrome is characterized by variable clinical manifestations including intellectual disability, short stature, scoliosis, digital abnormalities, cataracts, and dermatologic abnormalities.

Enhancing Access to Mental Health Services for Antepartum and Postpartum Women Through Telemental Health Services at Wellbeing Centers in Selected Health Facilities in Bangladesh: Implementation Research.

Background: Globally, 10% of pregnant women and 13% of postpartum women experience mental disorders. In Bangladesh, nearly 50% of mothers face common mental disorders, but mental health services and trained professionals to serve their needs are scarce. To address this, the government of Bangladesh's Non-Communicable Disease Control program initiated "Wellbeing Centers," telemental health services in selected public hospitals.

Simple and effective filtration system for drinking water production from harvested rainwater in rural areas.

Rainwater harvesting (RWH) for drinking water production has been a potential solution to mitigate water scarcity in rural areas. There was limited research focusing on the quality of treated rainwater. This study developed and tested the quality of a drinking water filtration system (DWFS) for treating harvested rainwater to support rural communities.

Correction: Developing climate-resilient rice varieties (BRRI dhan97 and BRRI dhan99) suitable for salt-stress environments in Bangladesh.

[This corrects the article DOI: 10.1371/journal.pone.

Wheelchair users function and satisfaction with modified wheelchair and intermediate wheelchair services in Pakistan.

Wheelchair users with poor trunk control and postural abnormalities require additional posture support devices and wheelchair modifications to sit upright. Therefore, this study was conducted to observe the function of wheelchair users in the modified wheelchair and their satisfaction with both the modified wheelchair and intermediate wheelchair service. A descriptive study was conducted, and 14 participants were recruited through consecutive sampling.

Basic Science and Pathogenesis.

Background: Alzheimer's disease (AD) is a neurogenerative disease that affect millions worldwide with no effective treatment. Several studies have been conducted to decipher to genomic underpinnings of AD. Due to its complex nature, many genes have been found to be associated with AD.

Health literacy among the rural Bangladeshi population on first aid measures and prevention of snakebite.

Background: Bangladesh has a high rate of snakebite. In rural areas, there is a significant mortality and morbidity rate due to lack of awareness and inappropriate first aid practices. This study aims to determine the knowledge and practices of the rural population in two subdistricts of Bangladesh regarding snakebite prevention and first aid measures.

Climate-smart agriculture and food security in climate-vulnerable coastal areas of Bangladesh.

The issue of global climate change is increasingly worrisome, particularly for countries heavily reliant on agriculture. To reduce the negative impact of climate change on agriculture, farmers of Bangladesh started adopting different climate smart agriculture (CSA) practices. The CSA sustainably increases productivity, resilience, and food security, which can contribute to the achievement of a number of sustainable development goals (SDGs).

A novel and efficient digital image steganography technique using least significant bit substitution.

Steganography is used to hide sensitive types of data including images, audio, text, and videos in an invisible way so that no one can detect it. Image-based steganography is a technique that uses images as a cover media for hiding and transmitting sensitive information over the internet. However, image-based steganography is a challenging task due to transparency, security, computational efficiency, tamper protection, payload, etc.

Spatial transcriptomics of healthy and fibrotic human liver at single-cell resolution.

Single-cell RNA sequencing (scRNA-seq) has advanced our understanding of cell types and their heterogeneity within the human liver, but the spatial organization at single-cell resolution has not yet been described. Here we apply multiplexed error robust fluorescent in situ hybridization (MERFISH) to map the zonal distribution of hepatocytes, spatially resolve subsets of macrophage and mesenchymal populations, and investigate the relationship between hepatocyte ploidy and gene expression within the healthy human liver. Integrating spatial information from MERFISH with the more complete transcriptome produced by single-nucleus RNA sequencing (snRNA-seq), also reveals zonally enriched receptor-ligand interactions.

3D highly isolated 6-port tri-band MIMO antenna system with 360° coverage for 5G IoT applications based machine learning verification.

A multipurpose antenna system that can handle a broad area of frequencies is crucial in the effort to build up widespread 5G Internet-of-Things (IoT) networks. For fifth-generation Internet-of-things applications, this research introduces a new multi-band antenna that can operate in the sub-6 GHz band (2-7 GHz), Ku-band (13-17.5 GHz), and millimeter wave band (25-39 GHz).

Automatic detection, classification, and segmentation of sagittal MR images for diagnosing prolapsed lumbar intervertebral disc.

Magnetic resonance (MR) images are commonly used to diagnose prolapsed lumbar intervertebral disc (PLID). However, for a computer-aided diagnostic (CAD) system, distinguishing between pathological abnormalities of PLID in MR images is a challenging and intricate task. Here, we propose a comprehensive model for the automatic detection and cropping of regions of interest (ROI) from sagittal MR images using the YOLOv8 framework to solve this challenge.

Trends in Mortality Due to Inflammatory Bowel Disease in the United States: A CDC WONDER Database Analysis (1999-2020).

Introduction: Inflammatory bowel disease (IBD) is a global health issue profoundly impacting quality of life. The United States accounts for nearly a quarter of the world's IBD patients, with the highest prevalence rates. This study aims to identify the demographic and regional trends of IBD-related mortality in the U.

Maternal and infant predictors of human milk macronutrient and energy concentrations in rural Bangladesh: an observational cohort study.

Background: Human milk macronutrient (protein, fat, and carbohydrate) and energy concentrations vary based on maternal and infant factors and time postpartum.

Objective: To determine the change in milk macronutrient and energy concentrations from approximately 2 to 5 months postpartum and identify factors associated with this variation among a lactation cohort in Bangladesh.

Methods: In this prospective observational lactation cohort in rural Sylhet, Bangladesh, we collected hand-expressed mid-feed human milk samples and analyzed macronutrient concentrations using mid-infrared spectroscopy.

Opportunities and challenges for human microphysiological systems in drug development.

Microphysiological systems (MPS) are complex in vitro tools that incorporate cells derived from various healthy or disease-state human or animal tissues and organs. While MPS have limitations, including a lack of globally harmonized guidelines for standardization, they have already proven impactful in certain areas of drug development. Further research and regulatory acceptance of MPS will contribute to making them even more effective tools in the future.

Assessment of Bacteriological Quality and Antibiotic Resistance in Locally and Industrially Produced Ice Creams: A Study on Probiotic Incorporation for Enhanced Safety and Health Benefits in Kushtia City, Bangladesh.

Ice creams are consumable foods that have the potential to be used as probiotic carriers. The purpose of this study was to evaluate the bacteriological quality (i.e.

Draft whole-genome sequence of isolate from a clinical sample from Dhaka, Bangladesh.

We collected a urine specimen from a 20-year-old male, cultured it on Chrom-agar , identified it with VITEK2, and whole-genome sequenced it using the PacBio RSII. The genome was 3,111,621 nucleotides long with a GC% of 37.6%.

Albizia procera-Derived Nitrogen-Doped Carbon for Advanced Energy Conversion, Storage, and Environmental Technologies.

This review explores the diverse applications of nitrogen-doped carbon derived from Albizia procera, known as white siris. Native to the Indian subcontinent and tropical Asia, this species thrives in varied conditions, contributing to sustainable development. The nitrogen-rich leaves of Albizia procera are an excellent source for synthesizing nitrogen-doped carbon, which possesses remarkable properties for advanced technologies.

Mitochondrial control region sequences show high genetic connectivity in the brownstripe snapper, (Quoy and Gaimard, 1824) from the east coast of Peninsular Malaysia.

The Brownstripe Snapper, (Quoy and Gaimard, 1824) is a commercially important snapper extensively caught in Malaysia. We examined genetic diversity, population connectivity, and historical demographics of the , off the eastern coast of peninsular Malaysia based on an 817 bp region of the mtDNA control region sequences. Maximum likelihood gene trees demonstrated that the populations under study had limited structuring and formed a single panmictic population that lacks support for internal clades.

Impact of rumen-protected glucose on performance, milk composition, and selected blood metabolites of early lactating Holstein Friesian cows.

Introduction: High-producing dairy cows often face calving stress and reduced feed intake during the transition period, leading to body fat mobilization to meet production demands. Supplementing rations with energy-dense sources like rumen-protected glucose (RPG) may enhance production performance in early lactation.

Methods: This study evaluated the effects of RPG supplementation on feed intake, body condition score (BCS), production performance, and blood metabolites in 32 early-lactation Holstein Friesian cows (6 ± 1 DIM; milk yield: 30 ± 5 kg/day; body weight: 550 ± 50 kg; BCS: 3.