The interplay of factors in metabolic syndrome: understanding its roots and complexity.

Metabolic syndrome (MetS) is an indicator and diverse endocrine syndrome that combines different metabolic defects with clinical, physiological, biochemical, and metabolic factors. Obesity, visceral adiposity and abdominal obesity, dyslipidemia, insulin resistance (IR), elevated blood pressure, endothelial dysfunction, and acute or chronic inflammation are the risk factors associated with MetS. Abdominal obesity, a hallmark of MetS, highlights dysfunctional fat tissue and increased risk for cardiovascular disease and diabetes.

Isolation and Characterization of Novel O157:H7 Phage SPEC13 as a Therapeutic Agent for Infections In Vitro and In Vivo.

O157:H7 is a recognized food-borne pathogen causing severe food poisoning at low doses. Bacteriophages (phages) are FDA-approved for use in food and are suggested as natural preservatives against specific pathogens. A novel phage must be identified and studied to develop a new natural preservative or antimicrobial agent against O157:H7.

Isolation and characterization of phage ISTP3 for bio-control application against drug-resistant .

including drug-resistant strains are major foodborne pathogens causing serious illness and pose a great threat to the prevention and control for food safety. Phages can naturally defect the bacterium, is considered as a new and promising biological antimicrobial agent in the post-antibiotic era. A poultry facility in Wuhan, China provided wastewater samples from which a collection of 29 phages were isolated and purified.

The power of phages: revolutionizing cancer treatment.

Cancer is a devastating disease with a high global mortality rate and is projected to increase further in the coming years. Current treatment options, such as chemotherapy and radiation therapy, have limitations including side effects, variable effectiveness, high costs, and limited availability. There is a growing need for alternative treatments that can target cancer cells specifically with fewer side effects.

Combine thermal processing with polyvalent phage LPEK22 to prevent the Escherichia coli and Salmonella enterica contamination in food.

Thermal processing is the most frequently used method to destruct bacteria in food processing. However, insufficient thermal processing may lead to the outbreak of foodborne illness. This study combined thermal processing with thermostable phage to prevent food contamination.

Isolation, Identification and Genetic Characterization of Antibiotic Resistant from Frozen Chicken Meat Obtained from Supermarkets at Dhaka City in Bangladesh.

Antimicrobials have been used to improve animal welfare, food security, and food safety that promote the emergence, selection, and dissemination of antimicrobial-resistant (AMR) bacteria. In this study, 50 were isolated from frozen chicken meat samples in Dhaka city. Antibiotic sensitivity patterns were assessed through the disk diffusion method and finally screened for the presence of antimicrobial resistance genes (ARG) using the polymerase chain reaction (PCR).

Application of a novel phage vB_SalS-LPSTLL for the biological control of Salmonella in foods.

Salmonella is one of the most common foodborne pathogens around the world. Phages are envisioned as a new strategy to control foodborne pathogenic bacteria and food safety. A Salmonella specific lytic phage vB_SalS-LPSTLL (LPSTLL) was selected for food applications on the basis of lytic range, lytic efficiency, functional stability and characteristics.

Construction and Characterization of an Multi-Gene Deletion Strain and Evaluation of Its Potential as a Live-Attenuated Vaccine in Grass Carp.

is an important pathogen that causes motile septicemia (MAS) in the aquaculture industry. Aerolysin, hemolysin, serine protease and enterotoxins are considered to be the major virulence factors of . In this study, we constructed a five-gene (A, , , and ) deletion mutant strain (named five-gene deletion strain, AHFGDS) to observe the biological characteristics and detect its potential as a live-attenuated vaccine candidate.

Characterization of Phage LPST153 That Effectively Targets Most Prevalent Serovars.

Foodborne diseases represent a major risk to public health worldwide. In this study, LPST153, a novel lytic phage with halo (indicative of potential depolymerase activity) was isolated by employing serovar Typhimurium ATCC 13311 as the host and had excellent lytic potential against . LPST153 is effectively able to lyse most prevalent tested serotypes of , including Typhimurium, Enteritidis, Pullorum and Gallinarum.

Application of a Broad Range Lytic Phage LPST94 for Biological Control of in Foods.

, one of the most common food-borne pathogens, is a significant public health and economic burden worldwide. Lytic phages are viable alternatives to conventional technologies for pathogen biocontrol in food products. In this study, 40 phages were isolated from environmentally sourced water samples.

Application of a Phage Cocktail for Control of in Foods and Reducing Biofilms.

contamination in foods and their formation of biofilms in food processing facility are the primary bacterial cause of a significant number of foodborne outbreaks and infections. Broad lytic phages are promising alternatives to conventional technologies for pathogen biocontrol in food matrices and reducing biofilms. In this study, 42 phages were isolated from environmentally-sourced water samples.

The two-component regulatory system CpxA/R is required for the pathogenesis of Aeromonas hydrophila.

Aeromonas hydrophila is a causative pathogen of many infectious diseases in fish and human. The two-component regulatory system enables bacteria to respond to a wide range of stimuli, growth conditions and environments. The two-component system CpxA/R is prevalent in microorganisms and involved in the pathogenesis of a number of pathogens.