Publications by authors named "Md Sharif Hasan"
Objectives: To predict and characterize the three-dimensional (3D) structure of protein arginine methyltransferase 2 (PRMT2) using homology modeling, besides, the identification of potent inhibitors for enhanced comprehension of the biological function of this protein arginine methyltransferase (PRMT) family protein in carcinogenesis.
Materials And Methods: An method was employed to predict and characterize the three-dimensional structure. The bulk of PRMTs in the PDB shares just a structurally conserved catalytic core domain.
Identification of Leading Compounds from (Dudsor) Extracts as a Potential Inhibitor of SARS-CoV-2 ACE2-RBDS1 Receptor Complex: An Insight from Molecular Docking ADMET Profiling and MD-simulation Studies.
Euroasian J Hepatogastroenterol
January 2023
Unlabelled: Coronavirus disease-19 (COVID-19) are deadly and infectious disease that impacts individuals in a variety of ways. Scientists have stepped up their attempts to find an antiviral drug that targets the spike protein (S) of Angiotensin converting enzyme 2 (ACE2) (receptor protein) as a viable therapeutic target for coronavirus. The most recent study examines the potential antagonistic effects of 17 phytochemicals present in the plant extraction of on the anti-SARS-CoV-2 ACE2 protein.
View Article and Find Full Text PDFUnlabelled: BACKGROUND : Wilson disease (WD) is an autosomal recessive disorder caused by mutation in the Adenosine Triphosphate 7B (ATP7B) gene. The spectrum of ATP7B mutation varies in different populations. The objective of this study was to identify the mutation in exon 8 and exon 14 of ATP7B gene in Bangladeshi children clinically diagnosed as WD.
View Article and Find Full Text PDFLeaf Juice on Mild and Moderate COVID-19 Patients: Implications in OMICRON Era.
Euroasian J Hepatogastroenterol
January 2022
Article Synopsis
- COVID-19 has severely impacted global public health systems, with a critical need for effective management strategies for mild and moderate cases to prevent severe complications.
- Despite various repurposed medications, there is still a significant need for new treatment options, especially considering emerging virus variants.
- A study assessing a herbal medication showed promising safety and efficacy results in moderate COVID-19 patients, leading to improved biochemical markers and reduced hospital stays compared to standard care alone.
Article Synopsis
- The study aimed to explore the pain-relieving, anxiety-reducing, central nervous system depressant, and blood sugar-lowering effects of metal complexes derived from naproxen.
- Researchers evaluated these effects using various tests, including acetic acid-induced writhing and tail-flick methods for pain relief, the elevated plus maze for anxiety, and glucose tolerance tests for hypoglycemia.
- Results indicated that metal complexes, particularly copper, cobalt, and zinc, showed significantly better performance in pain relief, anxiety reduction, CNS depression, and hypoglycemic effects compared to naproxen alone.
The aim of our current research was to synthesize some transition metal complexes of Naproxen, determine their physical properties, and examine their relative stability under various conditions. Characterizations of these complexes were done by 1H-NMR, Differential Scanning Calorimetry (DSC), FT-IR, HPLC, and scanning electron microscope (SEM). Complexes were subjected to acidic, basic, and aqueous hydrolysis as well as oxidation, reduction, and thermal degradation.
View Article and Find Full Text PDFClinical outcome in patients undergoing coronary artery bypass grafting using radial artery.
Bangladesh Med Res Counc Bull
December 2007