Depression like-behavior and memory loss induced by methylglyoxal is associated with tryptophan depletion and oxidative stress: a new in vivo model of neurodegeneration.

Background: Depression and memory loss are prevalent neurodegenerative disorders, with diabetic patients facing an elevated risk of brain dysfunction. Methylglyoxal (MGO) formation, which is heightened in diabetes owing to hyperglycemia and gut dysbiosis, may serve as a critical link between diabetes and brain diseases. Despite the high prevalence of MGO, the precise mechanisms underlying MGO-induced depression and memory loss remain unclear.

Correction: Samsuzzaman et al. A Synthetic Derivative SH 66 of Homoisoflavonoid from Liliaceae Exhibits Anti-Neuroinflammatory Activity against LPS-Induced Microglial Cells. 2024, , 3037.

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A Synthetic Derivative SH 66 of Homoisoflavonoid from Liliaceae Exhibits Anti-Neuroinflammatory Activity against LPS-Induced Microglial Cells.

Naturally occurring homoisoflavonoids isolated from some Liliaceae plants have been reported to have diverse biological activities (e.g., antioxidant, anti-inflammatory, and anti-angiogenic effects).

Access to chronic kidney disease (CKD) care: Its barriers and facilitators in a community development block in Purba Bardhaman, West Bengal: A qualitative study.

Background: Chronic kidney disease (CKD), a leading public health problem, has potential risks and serious implications on the health of individuals and society at large. Few studies explored the factors that influence access to CKD care at the community level in rural areas of West Bengal. A qualitative study was planned among key stakeholders to explore their views and experiences and to identify the barriers and potential facilitators that influence access to CKD care at the primary care level.

Synthesis of proposed structure of ledebourin A.

Naturally occurring homoisoflavonoids have attracted significant attention in the field of medicinal chemistry due to their potential health benefits and diverse range of biological properties. Recently, C-prenylated homoisoflavonoids, namely ledebourin A, B, and C, were isolated from the bulbs of Ledebouria floribunda and have exhibited potent antioxidant activity. In this study, we successfully synthesized ledebourin A and its regioisomer, compounds 1 and 9.

Sound-Based Localization Using LSTM Networks for Visually Impaired Navigation.

In this work, we developed a prototype that adopted sound-based systems for localization of visually impaired individuals. The system was implemented based on a wireless ultrasound network, which helped the blind and visually impaired to navigate and maneuver autonomously. Ultrasonic-based systems use high-frequency sound waves to detect obstacles in the environment and provide location information to the user.

Anti-Fibrotic Effects of DL-Glyceraldehyde in Hepatic Stellate Cells via Activation of ERK-JNK-Caspase-3 Signaling Axis.

During liver injury, hepatic stellate cells can differentiate into myofibroblast-like structures, which are more susceptible to proliferation, migration, and extracellular matrix generation, leading to liver fibrosis. Anaerobic glycolysis is associated with activated stellate cells and glyceraldehyde (GA) is an inhibitor of glucose metabolism. Therefore, this study aimed to investigate the anti-fibrotic effects of GA in human stellate LX-2 cells.

Design and Parametric Analysis of a Wide-Angle and Polarization Insensitive Ultra-Broadband Metamaterial Absorber for Visible Optical Wavelength Applications.

Researchers are trying to work out how to make a broadband response metamaterial absorber (MMA). Electromagnetic (EM) waves that can pass through the atmosphere and reach the ground are most commonly used in the visible frequency range. In addition, they are used to detect faults, inspect tapped live-powered components, electrical failures, and thermal leaking hot spots.

Slotted Monopole Patch Antenna for Microwave-Based Head Imaging Applications.

A modified monopole patch antenna for microwave-based hemorrhagic or ischemic stroke recognition is presented in this article. The designed antenna is fabricated on a cost-effective FR-4 lossy material with a 0.02 loss tangent and 4.

Identification of a potent NAFLD drug candidate for controlling T2DM-mediated inflammation and secondary damage and .

Accumulation of glucose/sugar results in the formation of reactive di-carbonyl compounds such as MGO and GO that interact with several amino acids and proteins to form toxic advanced glycation end products (AGEs). Induction of AGEs breakdown can control symptoms and severity in T2DM and other related complications like NAFLD where AGEs are the key players. Therefore, an AGE cross-link breaker has been suggested for preventing the onset/progression of NAFLD.

Symmetric Engineered High Polarization-Insensitive Double Negative Metamaterial Reflector for Gain and Directivity Enhancement of Sub-6 GHz 5G Antenna.

A symmetric engineered high polarization-insensitive double negative (DNG) metamaterial (MM) reflector with frequency tunable features for fifth-generation (5G) antenna gain and directivity enhancement is proposed in this paper. Four identical unique quartiles connected by a metal strip are introduced in this symmetric resonator that substantially tunes the resonance frequency. The proposed design is distinguished by its unique symmetric architecture, high polarization insensitivity, DNG, and frequency tunable features while retaining a high effective medium ratio (EMR).

Electromagnetic characterization of mirror symmetric resonator based metamaterial and frequency tuning: a dielectric based multilayer approach.

This article presents a novel metamaterial (MTM) with a mirror symmetric resonator that exhibits multiple resonances of transmission coefficient covering the L, S, C, and X bands. The resonating patch is constructed on a low-loss Rogers (RT5880) substrate with a dimension of 20 × 20 × 1.575 mm.

Exploring the contraceptive behaviour on spacing methods among the married women of reproductive age group in a rural area of Purba Bardhaman district, West Bengal - a qualitative study.

Introduction: One of the goals of the National Population Policy 2000 was to stabilize the population at a level consistent with the requirement of national economy. Spacing methods are reversible methods of contraception. Vision FP2020 will build on policy of increasing focus on spacing services through voluntary adoption of family planning.

Gain and isolation enhancement of a wideband MIMO antenna using metasurface for 5G sub-6 GHz communication systems.

This work proposes a compact metasurface (MS)-integrated wideband multiple-input multiple-output (MIMO) antenna for fifth generation (5G) sub-6 GHz wireless communication systems. The perceptible novelty of the proposed MIMO system is its wide operating bandwidth, high gain, lower interelement gap, and excellent isolation within the MIMO components. The radiating patch of the antenna is truncated diagonally with a partially ground plane, and a metasurface has been employed for enhancing the antenna performance.

Polarization insensitive split square ring resonator based epsilon-negative and near zero refractive index metamaterial for S, C, and X frequency bands satellite and radar communications.

This study has investigated the impact of inverse G-like shape resonators that exhibited epsilon negative (ENG) and near-zero refractive index (NZI) properties for multi-band wireless communications applications. The electrical measurement of structure is 0.118λ × 0.

Polarization insensitive dual band metamaterial with absorptance for 5G sub-6 GHz applications.

A couple ring enclosed circular geometric resonator (CRECGR) based dual-band polarization insensitive metamaterial (MM) with high effective medium ratio (EMR), and excellent absorptance is proposed in this study, which can be utilized as a sensor and absorber in the 5G sub-6 GHz frequency range. A circular geometry-based unique patch has been introduced in the proposed unit cell to achieve high polarization insensitive properties with excellent absorption for the 5G sub-6 GHz spectrum. The distinctive feature of this proposed CRECGR unit cell is its simple and unique structure with a high EMR of 11.

Gap coupled symmetric split ring resonator based near zero index ENG metamaterial for gain improvement of monopole antenna.

In this article, a symmetric split ring resonator (SRR) based metamaterial (MTM) is presented that exhibits three resonances of transmission coefficient (S) covering S, C, and X-bands with epsilon negative (ENG) and near zero index properties. The proposed MTM is designed on an FR4 substrate with the copper resonator at one side formed with two square rings and one circular split ring. The two square rings are coupled together around the split gap of the outer ring, whereas two split semicircles are also coupled together near the split gaps.

Reentrant melting of lanes of rough circular disks.

We consider binary suspension of rough, circular particles in two dimensions under athermal conditions. The suspension is subject to a time-independent external drive in response to which half of the particles are pulled along the field direction, whereas the other half is pushed in the opposite direction. Simulating the system with different magnitude of external drive in steady state, we obtain oppositely moving macroscopic lanes only for a moderate range of external drive.

Symmetric resonator based tunable epsilon negative near zero index metamaterial with high effective medium ratio for multiband wireless applications.

In this paper, a tuned metamaterial (MTM) consisting of a symmetric split ring resonator is presented that exhibits epsilon negative (ENG), near zero permeability and refractive index properties for multiband microwave applications. The proposed metamaterial is constituted on a Rogers (RT-5880) substrate with 1.57 mm thickness and the electrical dimension of 0.

Realization of frequency hopping characteristics of an epsilon negative metamaterial with high effective medium ratio for multiband microwave applications.

In this paper, a meander-lines-based epsilon negative (ENG) metamaterial (MTM) with a high effective medium ratio (EMR) and near-zero refractive index (NZI) is designed and investigated for multiband microwave applications. The metamaterial unit cell is a modification of the conventional square split-ring resonator in which the meander line concept is utilized. The meander line helps to increase the electrical length of the rings and provides strong multiple resonances within a small dimension.

Methylglyoxal-derived hemoglobin advanced glycation end products induce apoptosis and oxidative stress in human umbilical vein endothelial cells.

The presence of excess glucose promotes hemoglobin glycation via the biochemical modification of hemoglobin by dicarbonyl products. However, the precise effects of Hb-AGEs in human umbilical vein endothelial cells (HUVECs) are not known to date. Therefore, we investigated the tentative effects of Hb-AGEs in HUVECs.

Metamaterial array based meander line planar antenna for cube satellite communication.

This research article presents a design and performance analysis of a metamaterial inspired ultra-high frequency (UHF) compact planar patch antenna for the CubeSat communication system that could be smoothly integrated with commercially available 2U Cube Satellite structure and onboard subsystem. The proposed antenna consists of two layers, one is two different width meander line antenna patch with partial ground plane and another layer is 3 × 2 near-zero-indexed metamaterial (NZIM) metamaterial array structure with ground plane. The NZIM array layer has been utilized to minimize the coupling effect with Cube Satellite structure and improve the frequency stability with enhanced antenna gain and efficiency.

Developmental delay among children under two years of age in slums of Burdwan Municipality: A cross-sectional study.

Context: Development is an ongoing process through which an individual acquires competence to function adequately. Developmental delay is said to occur when a child fails to reach the age-appropriate anticipated milestones. This imparts long-term direct as well as indirect effects on the health of a community obviating routine measurement of its prevalence especially in high-risk populations.