Publications by authors named "Md Sailful Islam"
Article Synopsis
- The study focuses on the inhibition of JMJD6, an oxygenase linked to cancer, using 2-oxoglutarate mimics and competitors, including existing drugs and drug candidates.
- Researchers utilized NMR to observe how inhibitors bind to JMJD6 and mass spectrometry to track its lysine hydroxylation activity.
- Findings indicate that certain prolyl hydroxylase inhibitors also affect JMJD6, which could aid in creating selective inhibitors for oxygenases like JMJD6 in cancer therapy.
