Photoacoustic Resonators for Non-Invasive Blood Glucose Detection Through Photoacoustic Spectroscopy: A Systematic Review.

Diabetes mellitus is a prevalent disease with a rapidly increasing incidence projected worldwide, affecting both industrialized and developing regions. Effective diabetes management requires precise therapeutic strategies, primarily through self-monitoring of blood glucose levels to achieve tight glycemic control, thereby mitigating the risk of severe complications. In recent years, there have been significant advancements in non-invasive techniques for measuring blood glucose using photoacoustic spectroscopy (PAS), as it shows great promise for the detection of glucose using the infrared region (e.

Progress and Perspectives of Mid-Infrared Photoacoustic Spectroscopy for Non-Invasive Glucose Detection.

The prevalence of diabetes is rapidly increasing worldwide and can lead to a range of severe health complications that have the potential to be life-threatening. Patients need to monitor and control blood glucose levels as it has no cure. The development of non-invasive techniques for the measurement of blood glucose based on photoacoustic spectroscopy (PAS) has advanced tremendously in the last couple of years.

Dual quantum cascade lasers for noninvasive glucose detection using photoacoustic spectroscopy.

The combination of mid-infrared and photoacoustic spectroscopy has shown promising developments as a substitute for invasive glucose detection technology. A dual single-wavelength quantum cascade laser system has been developed using photoacoustic spectroscopy for noninvasive glucose monitoring. Biomedical skin phantoms with similar properties to human skin have been prepared with blood components at different glucose concentrations as test models for the setup.

A Hydrogel Microneedle Assay Combined with Nucleic Acid Probes for On-Site Detection of Small Molecules and Proteins.

Point-of-care testing (POCT) of clinical biomarkers is critical to health monitoring and timely treatment, yet biosensing assays capable of detecting biomarkers without the need for costly external equipment and reagents are limited. Blood-based assays are, specifically, challenging as blood collection is invasive and follow-upprocessing is required. Here, we report a versatile assay that employs hydrogel microneedles (HMNs) to extract interstitial fluid (ISF), in a minimally invasive manner integrated with graphene oxide-nucleic acid (GO.

A Critical Review on the Sensing, Control, and Manipulation of Single Molecules on Optofluidic Devices.

Single-molecule techniques have shifted the paradigm of biological measurements from ensemble measurements to probing individual molecules and propelled a rapid revolution in related fields. Compared to ensemble measurements of biomolecules, single-molecule techniques provide a breadth of information with a high spatial and temporal resolution at the molecular level. Usually, optical and electrical methods are two commonly employed methods for probing single molecules, and some platforms even offer the integration of these two methods such as optofluidics.

Gain investigation of Perylene-Red-doped PMMA for stimulated luminescent solar concentrators.

Luminescent solar concentrators (LSCs) utilizing stimulated emission by a seed laser are a promising approach to overcome the limitations of conventional LSCs, with a significant reduction of the photovoltaic material. In our previous work, we demonstrated the principle of a stimulated LSC (s-LSC) and correspondingly developed a model for quantifying the output power of such a system, taking into account different important physical parameters. The model suggested Perylene Red (PR) dye as a potential candidate for s-LSCs.

Modeling of stimulated emission based luminescent solar concentrators.

The efficiency improvement of luminescent solar concentrators (LSCs) necessary for practical realization is currently hindered by one major loss mechanism: reabsorption of emitted photons by the luminophores. Recently, we explored a promising technique for reducing reabsorption and also improving directional emission in LSCs utilizing stimulated emission, rather than only spontaneous emission, with an inexpensive seed laser. In this work, a model is developed to quantify the gain (i.

Luminescent solar concentrators utilizing stimulated emission.

Luminescent solar concentrators (LSCs) are an emerging technology that aims primarily to reduce the cost of solar energy, with great potential for building integrated photovoltaic (PV) structures. However, realizing LSCs with commercially viable efficiency is currently hindered by reabsorption losses. Here, we introduce an approach to reducing reabsorption as well as improving directional emission in LSCs by using stimulated emission.

Optical gain characterization of Perylene Red-doped PMMA for different pump configurations.

The optical gain is measured in Perylene Red (PR)-doped polymethyl methacrylate (PMMA) slabs for copropagating and transverse pumping configurations based on a single-pass pump-probe method where a small signal is used as a probe beam. The gain is characterized in terms of the stimulated gain coefficient (g(S)) for both pump configurations. This material property determines the strength of pump absorption and coupling to the probe signal beam through stimulated emission.