Characterization of the Effect of Drug-Drug Interaction on Protein Binding in Concurrent Administration of Sulfamethoxazol and Diclofenac Sodium Using Bovine Serum Albumin.

This project was aimed to determine the effect of concurrent administration of sulfamethoxazole and diclofenac sodium. Equilibrium dialysis method was adopted to study different protein binding aspects of sulfamethoxazole and diclofenac sodium. Sulfamethoxazole showed two types of association constants; high affinity constant 29.