Publications by authors named "Md Mosharef Hossain Bhuiyan"
Article Synopsis
- Thiosemicarbazones and their derivatives were synthesized as potential antimicrobial agents against harmful bacteria and fungi, using multi-step synthesis methods such as alkylation and esterification.* -
- The synthesized compounds were characterized using techniques like H NMR and FTIR, and computational tools were utilized to assess their drug-like properties and toxicity.* -
- Molecular docking studies indicated that these derivatives have a strong binding affinity against various pathogens, showing antibacterial activity comparable to standard drugs.*
Different esters were found potential against microorganisms, and could be a better choice to solve the multidrug resistant (MDR) pathogenic global issue due to their improved biological and pharmacokinetic properties. In this view, several 4--butylbenzoyl uridine esters with different aliphatic and aromatic groups were synthesized for antimicrobial, physicochemical and biological studies. antimicrobial tests against nine bacteria and three fungi along with prediction of activity spectra for substances (PASS) indicated promising antifungal functionality of these uridine esters compared to the antibacterial activities.
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