Publications by authors named "Md Jahidul Alam"

We investigate the hierarchical structure of Dhaka stocks' financial networks, known as an emerging market, from 2008 to 2020. To do so, we determine correlations from the returns of the firms over a one-year time window. Then, we construct a minimum spanning tree (MST) from correlations and calculate the hierarchy of the tree using the hierarchical path.

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Introduction: Many of the global pandemics threaten human existence over the decades among which coronavirus disease (COVID-19) is the newest exposure circulating worldwide. The RNA encoded severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus is referred as the pivotal agent of this deadly disease that induces respiratory tract infection by interacting host ACE2 receptor with its spike glycoprotein. Rapidly evolving nature of this virus modified into new variants helps in perpetrating immune escape and protection against host defense mechanism.

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Article Synopsis
  • Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer primarily linked to Merkel cell polyomavirus (MCPyV), which promotes tumor growth through its large T (LT) antigens.
  • The study aims to identify small natural antiviral compounds that can inhibit the proliferation of MCC by targeting the LT protein, using advanced computational drug design techniques.
  • From screening 2,190 phytochemicals, five promising compounds were identified with high binding energy values, highlighting their potential as therapeutic agents against MCPyV-related cancers.
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