Maternal experience of intimate partner violence, maternal depression, and parental stress are not associated with child telomere length in Bangladesh.

Shorter telomere length (TL) is associated with an increased risk for developing chronic or age-related diseases in adults. The process of telomere shortening is accelerated in response to stress and is well characterized in adult populations from high-income countries. Prior studies suggest the relationship between stress, shorter TL, and disease risk initiates in early life.

Correction: Investigating the functional and structural effect of non-synonymous single nucleotide polymorphisms in the cytotoxic T-lymphocyte antigen-4 gene: An in-silico study.

[This corrects the article DOI: 10.1371/journal.pone.

Emerging strategies in the sustainable removal of antibiotics using semiconductor-based photocatalysts.

In the constantly growing field of environmental sustainability, the threat of newly discovered pollutants, particularly antibiotics, has become a crucial concern. The widespread presence of these pharmaceutical substances in water sources presents a complex hazard to human health and ecological balance, requiring immediate and novel intervention techniques. Regarding this, semiconductor-based photocatalysts have appeared as promising candidates, providing a sustainable and efficient way to remove antibiotics from aquatic ecosystems.

Molecular screening and dynamics simulation reveal potential phytocompounds in Swertia chirayita targeting the UspA1 protein of Moraxella catarrhalis for COPD therapy.

Chronic obstructive pulmonary disease (COPD) is a global health burden, with Moraxella catarrhalis significantly contributing to acute exacerbations and increased healthcare challenges. This study aimed to identify potential drug candidates in Swertia chirayita, a traditional Himalayan medicinal plant, demonstrating efficacy against the ubiquitous surface protein A1 (UspA1) of M. catarrhalis through an in-silico computational approach.

Treatment heterogeneity of water, sanitation, hygiene, and nutrition interventions on child growth by environmental enteric dysfunction and pathogen status for young children in Bangladesh.

Background: Water, sanitation, hygiene (WSH), nutrition (N), and combined (N+WSH) interventions are often implemented by global health organizations, but WSH interventions may insufficiently reduce pathogen exposure, and nutrition interventions may be modified by environmental enteric dysfunction (EED), a condition of increased intestinal permeability and inflammation. This study investigated the heterogeneity of these treatments' effects based on individual pathogen and EED biomarker status with respect to child linear growth.

Methods: We applied cross-validated targeted maximum likelihood estimation and super learner ensemble machine learning to assess the conditional treatment effects in subgroups defined by biomarker and pathogen status.

Exploration of Antioxidative, Antidiarrheal, and Antihyperglycemic Properties of Leaves Along With In Silico Analysis.

is a rare member of the Moraceae family that is found in some Asian countries. This plant has some therapeutic uses in folk medicine. This project was carried out on the leaves of this plant to explore some of its pharmacological importance.

Investigating the Therapeutic Ability of Novel Antimicrobial Peptide Dendropsophin 1 and Its Analogues through Membrane Disruption and Monomeric Pore Formation.

Antimicrobial peptides (AMPs) are an alternative source of antibiotics that fight worldwide antibiotic-resistant catastrophes. Dendropsophin 1 (Dc1) is a recently invented novel AMP with 17 amino acid residues obtained from the screen secretion of a frog named . Dc1 has two slightly mutated analogues, namely, Dc1.

Enhancing PM2.5 prediction by mitigating annual data drift using wrapped loss and neural networks.

In many deep learning tasks, it is assumed that the data used in the training process is sampled from the same distribution. However, this may not be accurate for data collected from different contexts or during different periods. For instance, the temperatures in a city can vary from year to year due to various unclear reasons.

Evaluation of oral cholera vaccine (Euvichol-Plus) effectiveness against in Bangladesh: an interim analysis.

Introduction: Millions of Euvichol-Plus doses have been deployed from the global oral cholera vaccine stockpile in over 20 cholera-affected countries. However, information on Euvichol-Plus's effectiveness is limited. Using this vaccine in a cholera epidemic in Dhaka, Bangladesh, provided the opportunity to evaluate the vaccine effectiveness (VE) using a test-negative design.

A structural phylogenetic tree of Rad52 and its annealase superfamily.

Rad52, a highly conserved eukaryotic protein, plays a crucial role in DNA repair, particularly in double-strand break repair. Recent findings reveal that its distinct structural features, including a characteristic -sheet and -hairpin motif, are shared with the lambda phage single-strand annealing protein, Red, and other prokaryotic single-strand annealing proteins (SSAPs), indicating a common superfamily. Our analysis of over 10,000 SSAPs across all domains of life supports this hypothesis, confirming the presence of the characteristic motif despite variations in size and composition.

A systematic review and meta-analysis of the association between endothelial nitric oxide synthase (eNOS) rs2070744 polymorphism and preeclampsia.

Objective: Preeclampsia, characterized by hypertension and proteinuria, is a medical condition associated with maternal and fetal morbidity and mortality. Previous studies reported conflicting correlations between the eNOS rs2070744 variant and the occurrence of preeclampsia. Due to inconsistencies in findings, the purpose of the present meta-analysis was to explore the precise link between the eNOS rs2070744 variant and the development of preeclampsia.

Investigating the functional and structural effect of non-synonymous single nucleotide polymorphisms in the cytotoxic T-lymphocyte antigen-4 gene: An in-silico study.

The cytotoxic T-lymphocyte antigen-4 (CTLA4) is essential in controlling T cell activity within the immune system. Thus, uncovering the molecular dynamics of single nucleotide polymorphisms (SNPs) within the CTLA4 gene is critical. We identified the non-synonymous SNPs (nsSNPs), examined their impact on protein stability, and identified the protein sequences associated with them in the human CTLA4 gene.

A Review on the Role of Human Solute Carriers Transporters in Cancer.

Background And Aim: The high rate of tumor growth results in an increased need for amino acids. As solute carriers (SLC) transporters are capable of transporting different amino acids, cancer may develop as a result of these transporters' over-expression due to their complex formation with other biological molecules. Therefore, this review investigated the role of SLC transporters in the progression of cancer.

Molecular Characterization and Potential Inhibitors Prediction of Protein Arginine Methyltransferase-2 in Carcinoma: An Insight from Molecular Docking, ADMET Profiling and Molecular Dynamics Simulation Studies.

Objectives: To predict and characterize the three-dimensional (3D) structure of protein arginine methyltransferase 2 (PRMT2) using homology modeling, besides, the identification of potent inhibitors for enhanced comprehension of the biological function of this protein arginine methyltransferase (PRMT) family protein in carcinogenesis.

Materials And Methods: An method was employed to predict and characterize the three-dimensional structure. The bulk of PRMTs in the PDB shares just a structurally conserved catalytic core domain.

Optimization of cutting temperature and surface roughness in CNC turning of Ti-6Al-4V alloy using response surface methodology.

This study investigates the optimization of cutting conditions for machining titanium alloy (Ti-6Al-4V) using Response Surface Methodology (RSM), with the goal of minimizing tool-chip interface temperature and surface roughness. The research focuses on key cutting parameters to investigate the most effective combinations for enhancing surface finish and reducing thermal impact during machining. The present study deals with the dry turning of Ti-6Al-4V alloy with carbide alloy inserts in a way to utilize the Analysis of Variance (ANOVA) to develop predictive models for minimum surface roughness and optimum temperature.

First report on comprehensive genomic analysis of a multidrug-resistant Enterobacter asburiae isolated from diabetic foot infection from Bangladesh.

Enterobacter asburiae (E. asburiae) is a gram-negative rod-shaped bacterium which has emerging significance as an opportunistic pathogen having high virulence pattern and drug resistant properties. In this study, we present the detailed analysis of the whole genome sequence of a multidrug-resistant (MDR) E.

Intrusion detection system for V2X communication in VANET networks using machine learning-based cryptographic protocols.

Vehicle-to-everything (V2X) communication has many benefits. It improves fuel efficiency, road safety, and traffic management. But it raises privacy and security concerns.

Deep insights into the optoelectronic properties of AgCdF-based perovskite solar cell using the combination of DFT and SCAPS-1D simulation.

The main focus of this research is to explore the properties and photovoltaic application of AgCdF, and hence, initially, the CASTEP software was used in this study to assess the structural, optical, mechanical, and electrical characteristics of the AgCdF perovskite absorber layer within the context of the density functional theory (DFT) method. AgCdF resulting from the structural research is confirmed to be chemically and thermodynamically stable by the estimated tolerance factor and formation enthalpy. According to the band structure analysis, AgCdF is an indirect band gap semiconductor with a band gap of 1.

Drought vulnerability assessment and its impact on crop production and livelihood of people: An empirical analysis of Barind Tract.

North-Western section of Bangladesh is experiencing a protracted decrease in precipitation, irregular rainfall, and the depletion of ground water, which results in water scarcity and extreme dry weather that impedes the production of agricultural commodities and threatens the people's way of life. Analyzing the precipitation deficit and ground water deficit, along with vegetation cover, temperature condition, and the condition of the vegetation is a crucial component of drought vulnerability assessment. Rajshahi Zilla, a region of Bangladesh located in the middle of the Barind tract, is experiencing a severe water shortage.

Anxiolytic Effect of Sesamol, Possibly Through the GABAkine Interaction Pathway.

Plant-based components have helped generate novel lead molecules and scaffolds for anxiety research in psychopharmacology. The present study examined the anxiolytic properties of sesamol (SES), a phenolic lignan derived from Sesamum indicum, employing both in vivo and computational methods to understand its mechanisms of action. In this experiment, adult Swiss albino mice received various doses of SES (25 and 50 mg/kg, p.

Integer programming framework for pangenome-based genome inference.

Affordable genotyping methods are essential in genomics. Commonly used genotyping methods primarily support single nucleotide variants and short indels but neglect structural variants. Additionally, accuracy of read alignments to a reference genome is unreliable in highly polymorphic and repetitive regions, further impacting genotyping performance.

The Role of Protonation in the PfMATE Transporter Protein Structural Transitions.

Multi-antimicrobial extrusion (MATE) transporter membrane proteins provide drug and toxin resistivity by expelling compounds from cells. MATE proteins can be pictured as V-shaped. To regulate its functioning, the protein structure can switch between outward-facing (OF) and inward-facing (IF).

Discovery of key molecular signatures for diagnosis and therapies of glioblastoma by combining supervised and unsupervised learning approaches.

Glioblastoma (GBM) is the most malignant brain cancer and one of the leading causes of cancer-related death globally. So, identifying potential molecular signatures and associated drug molecules are crucial for diagnosis and therapies of GBM. This study suggested GBM-causing ten key genes (ASPM, CCNB2, CDK1, AURKA, TOP2A, CHEK1, CDCA8, SMC4, MCM10, and RAD51AP1) from nine transcriptomics datasets by combining supervised and unsupervised learning results.

Next generation power inverter for grid resilience: Technology review.

Distributed generation (DG) systems are becoming more popular due to several benefits such as clean energy, decentralization, and cost effectiveness. Because the majority of renewable energy sources provide DC power, power electronic inverters are necessary for their conversion from DC to AC power. To fulfill this demand, the next generation power inverter employs innovative technologies while simultaneously assuring stability and resilience.