Publications by authors named "Md Habibullah Sk"
Surfactant administration significantly improves respiratory outcomes in preterm infants with respiratory distress syndrome (RDS). However, surfactant administration may lead to hemodynamic alterations, particularly in the heart, affecting the patent ductus arteriosus (PDA), the consequences of which are not fully understood. This prospective observational study took place in an Indian neonatal care unit from July 2019 to November 2020, enrolling preterm neonates (26-34 weeks' gestation) with RDS needing non-invasive positive pressure ventilation.
View Article and Find Full Text PDFIntroduction: Noninvasive High-Frequency Oscillatory Ventilation (NHFOV) is increasingly being adopted to reduce the need for invasive ventilation after extubation.
Objectives: To evaluate the benefits and harms of NHFOV as post-extubation respiratory support in newborns compared to other non-invasive respiratory support modes.
Material & Methods: We included randomized controlled trials comparing NHFOV with other non-invasive modes post-extubation in newborns.
Article Synopsis
- Exogenous surfactant therapy is crucial for treating respiratory distress syndrome (RDS) in preterm infants, and the study focuses on the effectiveness of less invasive surfactant administration (LISA) using two types: beractant and poractant alfa.
- In a randomized controlled trial, 120 preterm infants (28-33 weeks) with RDS were treated with either beractant (100 mg/kg) or poractant-alfa (200 mg/kg), with intubation needs within 72 hours as the primary outcome.
- Results showed both treatments required intubation in 3.3% of cases, with no significant differences in effectiveness, but beractant was more cost-effective than poractant
Background: Less invasive surfactant administration (LISA) results in less need for mechanical ventilation and a reduction in death, bronchopulmonary dysplasia, and intraventricular hemorrhage as outcomes. This study aimed to evaluate the efficacy and short-term outcomes of surfactant administration by the LISA method using an 5F infant feeding tube in preterm infants.
Methods: During the period from May, 2019 to August, 2022, we carried out a prospective observational study that included all premature infants with respiratory distress syndrome who were admitted to our neonatal intensive care unit.