Global land subsidence mapping reveals widespread loss of aquifer storage capacity.

Groundwater overdraft gives rise to multiple adverse impacts including land subsidence and permanent groundwater storage loss. Existing methods are unable to characterize groundwater storage loss at the global scale with sufficient resolution to be relevant for local studies. Here we explore the interrelation between groundwater stress, aquifer depletion, and land subsidence using remote sensing and model-based datasets with a machine learning approach.

Identification of Potential Diuretic and Laxative Drug Candidates from L. Bark through Mice Model Studies and Gas Chromatography-Mass Spectrometry and Molecular Docking Analysis.

Background: is a medicinal plant that has traditionally been used as a diuretic, anti-infective, and antiasthmatic. Our investigation was designed to explore the diuretic and laxative potentials of different fractions of this plant's bark extract as well as the identification of possible drug candidates for the activity.

Methods: Collected bark was extracted in ethanol and fractionated in different polar and nonpolar solvents, i.

, Molecular Docking and Antimicrobial Activity of the Major Rapeseed Seed Storage Proteins.

Background: In addition to their use as an edible oil and condiment crop, mustard and rapeseed ( L., (L.) Czern.

Curcumin and its Multi-target Function Against Pain and Inflammation: An Update of Pre-clinical Data.

Pain is an unpleasant sensation that has complex and varying causative etiology. Modern drug discovery focuses on identifying potential molecules that target multiple pathways with a safer profile compared to those with a single target. The current treatment of pain and inflammation with the available therapeutics has a number of major side effects.