Unveiling the antimicrobial potentials of : an integrated experimental and computer aided investigation.

Although in the last three decades pharmaceutical industries invented good number of new drugs, resistance to antimicrobials is still prevailing due to the remarkable genetic plasticity of the microbes and drugs. In this present study, we have shown, exhibited maximum zone of inhibition (20.5 ± 0.

GC-MS analysis and pharmacological potentiality of (L.) Thwaites leaves and fruit extracts: an in vitro and in silico studies.

() is widely used in Asian countries for treating various diseases and as a vegetable, yet its bioactive properties remain under-researched. It is traditionally utilized in Ayurveda and the AYUSH system of medicine for its medicinal properties, and commonly used to treat digestive disorders, respiratory issues, and inflammatory conditions. This study aims to identify the phytochemicals in leaves and fruit extracts and evaluate their biological activities.

Evaluation of -derived compounds against diabetes mellitus: insight into the phytochemical analysis and assays.

is a medicinal plant with numerous potential secondary metabolites showing a significant level of antidiabetic activity. The objective of the current study was to identify potential phytochemicals from the methanolic leaf extract of as therapeutic agents against diabetes mellitus using GC-MS and methods. The GC-MS analysis of the leaf extract revealed a total of 17 phytochemicals.

Synthesis of Silver Nanoparticles Using Camellia sinensis Leaf Extract: Promising Particles for the Treatment of Cancer and Diabetes.

Both diabetes and cancer pose significant threats to public health. To overcome these challenges, nanobiotechnology offers innovative solutions for the treatment of these diseases. However, the synthesis of nanoparticles can be complex, costly and environmentally toxic.

Biochemical and molecular docking-based strategies of and extract by targeting bacterial strains and cancer proteins.

Antibiotic-resistant microbes have emerged around the world, presenting a risk to health. Plant-derived drugs have become a potential source for the production of antibiotic-resistant drugs and cancer therapies. In this study, we investigated the antibacterial, cytotoxic and antioxidant properties of and , and conducted molecular docking experiments against EGFR and VEGFR-2 proteins.

Unveiling Neuroprotective Potential of Spice Plant-Derived Compounds against Alzheimer's Disease: Insights from Computational Studies.

Alzheimer's disease (AD) is a serious threat to the global health care system and is brought on by a series of factors that cause neuronal dysfunction and impairment in memory and cognitive decline. This study investigated the therapeutic potential of phytochemicals that belong to the ten regularly used spice plants, based on their binding affinity with AD-associated proteins. Comprehensive docking studies were performed using AutoDock Vina in PyRx followed by molecular dynamic (MD) simulations using AMBER 14.

Molecular docking and dynamics simulation approach of leaf extract derived compounds as potential cholinesterase inhibitors.

The tea plant () belongs to the family Theaceae and contains many phytochemicals that are effective against various diseases, including neurodegenerative disorders. In this study, we aimed to characterize the phytochemicals present in the methanolic and n-hexane leaf extracts of using GC-MS, FTIR, and UV-visible analysis. We detected a total of 19 compounds of different chemical classes.

Work-Life Balance, Job Satisfaction, and Job Performance of SMEs Employees: The Moderating Role of Family-Supportive Supervisor Behaviors.

Even though studies on work-life balance and family-supportive supervisor behaviors are prevalent, there are few studies in the SME setting, and the implications are yet unexplained. Thus, the study examines the effect of work-life balance on the performance of employees in SMEs, along with the mediating role of job satisfaction and the moderating role of family-supportive supervisor behaviors. We have developed a conceptually mediated-moderated model for the nexus of work-life balance and job performance.

The impact of COVID-19 on tertiary educational institutions and students in Bangladesh.

The COVID-19 forced to transform face-to-face mode of teaching to virtual in educational institutions around the globe that not only impact institutional stakeholders, but also posed as a threat to entire humanity because, all parties related to education had to change their activities. The intentions of this study therefore firstly, to determine the content analysis by interviewing tertiary students and secondly, to determine the frequency distribution by questionnaire developed from results of the content analysis. To better understand the consequences of this outbreak, we took an interview from forty respondents, including undergraduate and postgraduate students across Bangladesh.

Molecular identification and biological control of from wilt of papaya by natural compounds and : An integrated experimental and computational study.

is a harmful pathogen that causes severe wilt disease in several vegetables. In the present study, we identified from wilt of papaya by 16S rRNA PCR amplification. Virulence ability of was determined by amplification of approximately 1500 bp clear band of gene.

The investigation of nonsynonymous SNPs of human gene associated with depression: An approach.

Genetic polymorphism of the gene is associated with several behavioral disorders, including depression. Since studying the total nonsynonymous single nucleotide polymorphisms (nsSNPs) of the gene at the population level is a difficult task, we aim to utilize approach to detect the most deleterious nsSNPs of the gene. In our study, 7 computational tools were used in the initial stage, including SIFT, Polyphen-2, PROVEAN, SNAP2, PhD-SNP, PANTHER, and SNPs&GO to find out the most damaging nsSNPs.

Anti-HBc Screening of Blood Donors in Bangladesh: Relevance to Containment of HBV Propagation.

Objectives: To avoid further transmission of hepatitis B virus (HBV) infection, blood is tested for hepatitis B surface antigen (HBsAg) before transfusion. However, post-transfusion hepatitis B has been detected in clinics after transfusion of HBsAg-negative blood. The study presented here was undertaken to assess if HBsAg-negative blood is free from HBV or not.