Factors influencing mental health outcomes among university students: a cross-sectional study in Bangladesh.

Introduction: Mental health issues, particularly anxiety and depression, are on the rise among university students globally, including in Bangladesh. However, comprehensive data on the factors influencing mental health outcomes in this group remain limited, hindering the development of effective programmes and interventions.

Objectives: This study aims to assess the mental health status of university students in Bangladesh and examine the key factors influencing mental health outcomes.

Therapeutic potential of flavonoids in neuroprotection: brain and spinal cord injury focus.

Flavonoids in fruits, vegetables, and plant-based drinks have potential neuroprotective properties, with clinical research focusing on their role in reducing oxidative stress, controlling inflammation, and preventing apoptosis. Some flavonoids, such as quercetin, kaempferol, fisetin, apigenin, luteolin, chrysin, baicalein, catechin, epigallocatechin gallate, naringenin, naringin, hesperetin, genistein, rutin, silymarin, and daidzein, have been presented to help heal damage to the central nervous system by affecting key signaling pathways including PI3K/Akt and NF-κB. This review systematically analyzed articles on flavonoids, neuroprotection, and brain and spinal cord injury from primary medical databases like Scopus, PubMed, and Web of Science.

Pharmacophore-guided computational modeling of quinolone-ATPase conjugate inhibitors targeting DNA GyrB subunit of Staphylococcus aureus.

The rapid rise of antibiotic-resistant bacterial strains is a significant global health issue, necessitating the development of new and effective antimicrobial agents. This study focuses on designing synthetic de novo models of fluoroquinolone (FQ) descriptors by fusing the quinolone ring-a derivative of FQs-with potential ATPase inhibitors, which is identified through pharmacophore modeling targeting the DNA gyrase B (gyrB) protein of S. aureus.

Bird's eye view of natural products for the development of new anti-HIV agents: Understanding from a therapeutic viewpoint.

Acquired immune deficiency syndrome (AIDS) is the name used to describe several potentially life-threatening infections and disorders that happen when HIV has severely compromised the immune system. The primary effect of HIV is to decrease host immunity, exposing the host to external pathogens. The development of pharmaceutical drugs that directly cure the infection is crucial because of the current wide-ranging epidemic of HIV.

Phytochemical-Based Drug Discovery for Breast Cancer: Combining Virtual Screening and Molecular Dynamics to Identify Novel Therapeutics.

Maternal embryonic leucine zipper kinase (MELK), a pivotal signaling protein, plays a crucial role in various physiological processes, such as cell growth, survival, and differentiation. There is currently a growing interest in MELK as a promising therapeutic target for multiple cancers, including triple-negative breast cancer (TNBC). Exploring MELK as a target offers a prospective strategy to impede cancer progression and enhance the efficacy of conventional anticancer therapies.

Histological Changes of the Mucosal Epithelium in the Chicken Intestine during Pre- and Post-Hatching Stages.

This study clarified the histological changes in the mucosal epithelium of the chicken intestine during the pre- and post-hatching stages. The duodenum, jejunum, ileum, and colorectum were collected from embryos at 15, 17, 18, 19, and 21 days of incubation and from chicks at 1 and 3 days after hatching. Paraffin sections prepared from tissue samples were stained with periodic acid-Schiff followed by alcian blue for histological analysis and to detect goblet cells.

Designing siRNA for silencing the human ERBB2 gene in cancer treatment: Evaluating intracellular delivery strategies.

The ERBB2 is one of the most studied genes in oncology for its significant role in human malignancies. The metastasis-associated properties that facilitate cancer metastasis can be enhanced by activating the ERBB2 receptor signaling pathways. Additionally, therapeutic resistance is conferred by ERBB2 overexpression via receptor-mediated antiapoptotic signals.

Molecular Characterization and Potential Inhibitors Prediction of Protein Arginine Methyltransferase-2 in Carcinoma: An Insight from Molecular Docking, ADMET Profiling and Molecular Dynamics Simulation Studies.

Objectives: To predict and characterize the three-dimensional (3D) structure of protein arginine methyltransferase 2 (PRMT2) using homology modeling, besides, the identification of potent inhibitors for enhanced comprehension of the biological function of this protein arginine methyltransferase (PRMT) family protein in carcinogenesis.

Materials And Methods: An method was employed to predict and characterize the three-dimensional structure. The bulk of PRMTs in the PDB shares just a structurally conserved catalytic core domain.

Influences of the short-term dietary carbohydrate restriction on the chicken cecal tonsil.

This study aims to clarify influences of the short-term carbohydrate (CHO) restriction on plasma cells in chicken cecal tonsil (CT) using immunohistochemical and morphometrical techniques. Healthy male layer chickens were randomly divided into the control and three experimental groups. The three experimental groups were fed with diets containing 50%, 25%, and 0% CHO of that in the control diet, respectively.

Extraction of wood vinegar from bagasse and its application as bio-reducer to produce stable silver nanoparticles with enhanced antibacterial activity.

Global efforts have been made to address environmental and health concerns by promoting and adopting renewable natural resources. This study investigated the role of bagasse-based wood vinegar to synthesize and stabilize silver nanoparticles. We present a simple bottom-up approach to produce silver nanoparticles using the green reducing agent.

Determinants of depression among ever-married adolescent girls in Bangladesh: Evidence from the Bangladesh Adolescent Health and Wellbeing Survey 2019-2020.

Background: Common mental health disorders in early life represent a major challenge and these conditions become more complicated and substantial during the development period of adolescence. Despite the global concern over the increasing prevalence of mental health issues among adolescents, it remains largely a neglected area of research and health policy in Bangladesh, where the burden of child marriage is significantly higher. This study aimed to investigate the prevalence and factors associated with depression among married adolescent girls in Bangladesh.

The first report of concurrent infection of hemorrhagic septicemia with foot and mouth disease in cattle in Bangladesh.

This study aimed to investigate the concurrent infection of Pasteurella multocida (P. multocida) type B:2, which causes Hemorrhagic Septicemia (HS), with cases of Foot and Mouth Disease (FMD) outbreaks in cattle in Bangladesh between March and December 2023. Samples were collected from 11 distinct outbreak areas, totaling 102 samples.

Exploring determinants of early marriage among women in Bangladesh: A multilevel analysis.

Introduction: Early marriage, defined as marriage under the age of 18, is widely recognized as a human rights violation with deleterious consequences on women's health and well-being. It persists as a significant global public health issue, predominantly being practiced in South Asian countries. In Countries like Bangladesh, this practice contributes to an increase in early pregnancies among women of reproductive age, further exacerbating adverse maternal and child health outcomes.

Engineering Novel Amphiphilic Platinum(IV) Complexes to Co-Deliver Cisplatin and Doxorubicin.

In this study, we report a novel platinum-doxorubicin conjugate that demonstrates superior therapeutic indices to cisplatin, doxorubicin, or their combination, which are commonly used in cancer treatment. This new molecular structure () was formed by conjugating an amphiphilic Pt(IV) prodrug of cisplatin with doxorubicin. Due to its amphiphilic nature, the Pt(IV)-doxorubicin conjugate effectively penetrates cell membranes, delivering both cisplatin and doxorubicin payloads intracellularly.

A novel approach for the modification of eggshell powder and its application for lead and methylene blue removal.

Water pollution is one of the major concerns due to rapid industrialization and urbanization. Wastewater treatment has been an area of great interest for the researchers and among many technologies developed for water treatment, adsorption is the most preferred due to its efficiency and ability of been economical method. In this research, eggshell powder (ESP) is converted into modified eggshell powder (MESP) through chemical and thermal treatment (at 550 °C for 2 h) to use it as an adsorbent to remediate Pb and Methylene blue (MB) from water, then it is transferred into modified eggshell powder magnetic composite (MESPMC) with iron coating to resolve the separation challenges and to boost the MESP's adsorption efficiency.

Alkaloid-based modulators of the PI3K/Akt/mTOR pathway for cancer therapy: Understandings from pharmacological point of view.

This review aims to summarize the role of alkaloids as potential modulators of the PI3K/Akt/mTOR (PAMT) pathway in cancer therapy. The PAMT pathway plays a critical role in cell growth, survival, and metabolism, and its dysregulation contributes to cancer hallmarks. In healthy cells, this pathway is tightly controlled.

Soliton structures of fractional coupled Drinfel'd-Sokolov-Wilson equation arising in water wave mechanics.

This article delves into the dynamic constructions of distinctive traveling wave solutions for wave circulation in shallow water mechanics, specifically addressing the time-fractional couple Drinfel'd-Sokolov-Wilson (DSW) equation. Introducing the previously untapped -expansion method, we successfully generate a diverse set of analytic solutions expressed in hyperbolic, trigonometric, and rational functions, each with permitted parameters. Visualization through three-dimensional (3D) as well two-dimensional (2D) plots, including contour plots, reveals inherent wave phenomena in the DSW equation.

Enriching Wheat Bread With Banana Peel Powder: Impact on Nutritional Attributes, Bioactive Compounds, and Antioxidant Activity.

This research investigated the impact of enriching bread with banana peel powder (BPP) on nutritional attributes, bioactive components, antioxidant activity, and sensory characteristics. Four bread samples were prepared and evaluated: S1 (control), S2 (5% BPP), S3 (7% BPP), and S4 (10% BPP). The addition of BPP resulted in a reduction in moisture content and an increase in ash, fat, protein, and fibre levels, while reducing overall carbohydrate content.

Monoterpenoid synergy: a new frontier in biological applications.

Monoterpenoids, compounds found in various organisms, have diverse applications in various industries. Their effectiveness is influenced by the oil's chemical composition, which in turn is influenced by plant genotype, environmental conditions, cultivation practices, and plant development stage. They are used in various industries due to their distinctive odor and taste, serving as ingredients, additives, insecticides, and repellents.

Structure-based pharmacophore modeling for precision inhibition of mutant ESR2 in breast cancer: A systematic computational approach.

Background: Breast cancer, a leading cause of female mortality, is closely linked to mutations in estrogen receptor beta (ESR2), particularly in the ligand-binding domain, which contributed to altered signaling pathways and uncontrolled cell growth.

Objectives/aims: This study investigates the molecular and structural aspects of ESR2 mutant proteins to identify shared pharmacophoric regions of ESR2 mutant proteins and potential therapeutic targets aligned within the pharmacophore model.

Methods: This study was initiated by establishing a common pharmacophore model among three mutant ESR2 proteins (PDB ID: 2FSZ, 7XVZ, and 7XWR).

From farm to function: Exploring new possibilities with jute nanocellulose applications.

Recent scientific interest has surged in the application of bioresources within nanotechnology, primarily because of their eco-friendly nature, wide availability, and cost-effectiveness. Jute is globally recognized as the second most prevalent source of natural cellulose fibers, and it produces a significant quantity of jute sticks as a byproduct. Nanocellulose (NC), which includes cellulose nanofibrils (CNF) and cellulose nanocrystals (CNC), exhibits exceptional properties such as high strength, toughness, crystallinity, thermal stability, and stiffness.

On simulations of 3D fractional WBBM model through mathematical and graphical analysis with the assists of fractionality and unrestricted parameters.

This study retrieves some novel exact solutions to the family of 3D space-time fractional Wazwaz-Benjamin-Bona-Mahony (WBBM) equations in the context of diverse nonlinear physical phenomena resulting from water wave mechanics. The family of WBBM equations is transformed for this purpose using a space and time fractional transformation into an ordinary differential equation (ODE). The ODE then uses a strong method, namely the Unified Method.

Enhancing resilience in transnational E-commerce supply chains: Critical factors, perspectives and strategic action plan.

This study develops a hybrid model to investigate the factors affecting transnational e-commerce supply chain resilience (TNSCRE) by integrating the Entropy Weight Method (EWM), Simple Additive Weighting (SAW), and Interpretive Structural Modeling (ISM). The study identifies 36 critical factors categorized under supply chain adaptability, supply chain efficiency, and supply chain evolution, and five criteria are used to rank these factors. The EWM is used to calculate the relative weights of the criteria, and the SAW method is used to rank the factors based on their weighted scores.

Morphostructural studies of pure and mixed metal oxide nanoparticles of Cu with Ni and Zn.

Nano-scale interactions between pure metal or metal-oxide components within an oxide matrix can improve functional performance over basic metal oxides. This study reports on the synthesis of monometallic (CuO), bimetallic (CuO-NiO) and trimetallic (CuO-NiO-ZnO) oxide nanoparticles (NPs) via the co-precipitation method and investigation of morphostructural properties. All of the synthesized metal oxide NPs were calcined at 550 °C temperature and annealed under vacuum.

Effects of SPI1-mediated transcriptome remodeling on Alzheimer's disease-related phenotypes in mouse models of Aβ amyloidosis.

SPI1 was recently reported as a genetic risk factor for Alzheimer's disease (AD) in large-scale genome-wide association studies. However, it is unknown whether SPI1 should be downregulated or increased to have therapeutic benefits. To investigate the effect of modulating SPI1 levels on AD pathogenesis, we performed extensive biochemical, histological, and transcriptomic analyses using both Spi1-knockdown and Spi1-overexpression mouse models.