N-acetyl-D-glucosamine kinase is a component of nuclear speckles and paraspeckles.

Protein O-GlcNAcylation, dictated by cellular UDP-N-acetylglucosamine (UDP-GlcNAc) levels, plays a crucial role in posttranslational modifications. The enzyme GlcNAc kinase (NAGK, E.C.

Adsorption of 2,4-dichlorophenoxyacetic acid by mesoporous activated carbon prepared from H3PO4-activated langsat empty fruit bunch.

The removal of toxic herbicide from wastewater is challenging due to the availability of suitable adsorbents. The Langsat empty fruit bunch is an agricultural waste and was used in this study as a cheap precursor to produce activated carbon for the adsorption of herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) at different initial concentrations ranging from 50 to 400 mg/L. The produced Langsat empty fruit bunch activated carbon (LEFBAC) was mesoporous and had high surface area of 1065.

Aspect of thrombolytic therapy: a review.

Thrombolytic therapy, also known as clot busting drug, is a breakthrough treatment which has saved untold lives. It has been used in the clinical area to treat venous and arterial thromboembolic complaints which are a foremost cause of death. In 1761, Morgagni lead the way of thrombolytic therapy.

Pyrolysis kinetics of raw and hydrothermally carbonized Karanj (Pongamia pinnata) fruit hulls via thermogravimetric analysis.

The pyrolysis of karanj fruit hulls (KFH) and karanj fruit hull hydrothermal carbonization (KFH-HTC) hydrochar was thermogravimetrically investigated under a nitrogen environment at 5 °C/min, 10 °C/min, and 20 °C/min. The pyrolysis decomposition of KFH biomass was faster than that of KFH-HTC hydrochar because of the high volatility and fixed carbon of KFH biomass. Weight loss percentage was also affected by the heating rates.

Exploration of the structural requirements of HIV-protease inhibitors using pharmacophore, virtual screening and molecular docking approaches for lead identification.

Pharmacoinformatics approaches are widely used in the field of drug discovery as it saves time, investment and animal sacrifice. In the present study, pharmacore-based virtual screening was adopted to identify potential HIV-protease ligands as anti-HIV agents. Pharmacophore is the 3D orientation and spatial arrangement of functional groups that are critical for binding at the active site cavity.

The fungal natural product (1S,3S)-austrocortirubin induces DNA damage in HCT116 cells via a mechanism unique from other DNA damaging agents.

Screening a series of natural product-based tetrahydroanthraquinones led to the identification of a novel molecule, (1S,3S)-austrocortirubin (2), which acts via inducing DNA damage. Compound 2 has a GI50 of 3μM against HCT116 and induces apoptosis. Mechanism of action studies indicate that it causes significant DNA damage during G0/G1, S, and G2 cell cycle phases.

Honey: a potential therapeutic agent for managing diabetic wounds.

Diabetic wounds are unlike typical wounds in that they are slower to heal, making treatment with conventional topical medications an uphill process. Among several different alternative therapies, honey is an effective choice because it provides comparatively rapid wound healing. Although honey has been used as an alternative medicine for wound healing since ancient times, the application of honey to diabetic wounds has only recently been revived.

EMG-force relationship during static contraction: Effects on sensor placement locations on biceps brachii muscle.

Background: The relationship between surface electromyography (EMG) and force have been the subject of ongoing investigations and remain a subject of controversy. Even under static conditions, the relationships at different sensor placement locations in the biceps brachii (BB) muscle are complex.

Objective: The aim of this study was to compare the activity and relationship between surface EMG and static force from the BB muscle in terms of three sensor placement locations.

Dynamics of Japanese encephalitis virus transmission among pigs in Northwest Bangladesh and the potential impact of pig vaccination.

Background: Japanese encephalitis (JE) virus infection can cause severe disease in humans, resulting in death or permanent neurologic deficits among survivors. Studies indicate that the incidence of JE is high in northwestern Bangladesh. Pigs are amplifying hosts for JE virus (JEV) and a potentially important source of virus in the environment.

Development of multidrug resistant tuberculosis in Bangladesh: a case-control study on risk factors.

Objective: To determine the risk factors for developing multidrug resistant tuberculosis in Bangladesh.

Methods: This case-control study was set in central, district and sub-district level hospitals of rural and urban Bangladesh. Included were 250 multidrug resistant tuberculosis (MDR-TB) patients as cases and 750 drug susceptible tuberculosis patients as controls.

Longitudinal, lateral and transverse axes of forearm muscles influence the crosstalk in the mechanomyographic signals during isometric wrist postures.

Problem Statement: In mechanomyography (MMG), crosstalk refers to the contamination of the signal from the muscle of interest by the signal from another muscle or muscle group that is in close proximity.

Purpose: The aim of the present study was two-fold: i) to quantify the level of crosstalk in the mechanomyographic (MMG) signals from the longitudinal (Lo), lateral (La) and transverse (Tr) axes of the extensor digitorum (ED), extensor carpi ulnaris (ECU) and flexor carpi ulnaris (FCU) muscles during isometric wrist flexion (WF) and extension (WE), radial (RD) and ulnar (UD) deviations; and ii) to analyze whether the three-directional MMG signals influence the level of crosstalk between the muscle groups during these wrist postures.

Methods: Twenty, healthy right-handed men (mean ± SD: age = 26.

EMG-force relationship during static contraction: effects on sensor placement locations on biceps brachii muscle.

Background: The relationship between surface electromyography (EMG) and force have been the subject of ongoing investigations and remain a subject of controversy. Even under static conditions, the relationships at different sensor placement locations in the biceps brachii (BB) muscle are complex.

Objective: The aim of this study was to compare the activity and relationship between surface EMG and static force from the BB muscle in terms of three sensor placement locations.

Premorbid adjustment profiles in psychosis and the role of familial factors.

Disease heterogeneity in patients with psychotic disorder may be explained by distinct profiles of premorbid adjustment. The current study explored premorbid adjustment profiles in patients with psychotic disorders, associations with cognitive and clinical characteristics after disease onset, and the role of familial factors. A total of 666 patients with psychosis (predominantly schizophrenia), 673 siblings, 575 parents, and 585 controls were included in this study.

Evaluation of repetitive isometric contractions on the heads of triceps brachii muscle during grip force exercise.

Objectives: Normally, surface electromyography electrodes are used to evaluate the activity of superficial muscles during various kinds of voluntary contractions of muscle fiber. The objective of the present study was to investigate the effect of repetitive isometric contractions on the three heads of the triceps brachii muscle during handgrip force exercise.

Methods: Myoelectric signals were recorded from the lateral, long and medial heads of the triceps brachii muscle in 13 healthy males during maximal isometric contractions for 10 s of concurrent handgrip force and elbow extension.

High-risk behavior of HIV/AIDS among females sex workers in Bangladesh: survey in Rajshahi City.

Female sex workers (FSWs) and their clients are one of the major sources of spread of HIV/AIDS in Bangladesh. The purpose of this study was to determine the rate of unprotected sex among FSWs in Rajshahi City, Bangladesh. A total of 200 FSWs were randomly selected for the survey from February to September 2012.

Cross-talk in mechanomyographic signals from the forearm muscles during sub-maximal to maximal isometric grip force.

Purpose: This study aimed: i) to examine the relationship between the magnitude of cross-talk in mechanomyographic (MMG) signals generated by the extensor digitorum (ED), extensor carpi ulnaris (ECU), and flexor carpi ulnaris (FCU) muscles with the sub-maximal to maximal isometric grip force, and with the anthropometric parameters of the forearm, and ii) to quantify the distribution of the cross-talk in the MMG signal to determine if it appears due to the signal component of intramuscular pressure waves produced by the muscle fibers geometrical changes or due to the limb tremor.

Methods: Twenty, right-handed healthy men (mean ± SD: age  = 26.7±3.

Hybrid markerless tracking of complex articulated motion in golf swings.

Sports video tracking is a research topic that has attained increasing attention due to its high commercial potential. A number of sports, including tennis, soccer, gymnastics, running, golf, badminton and cricket have been utilised to display the novel ideas in sports motion tracking. The main challenge associated with this research concerns the extraction of a highly complex articulated motion from a video scene.

Surface electromyographic analysis of the biceps brachii muscle of cricket bowlers during bowling.

Cricket bowling generates forces with torques on the upper limb muscles and makes the biceps brachii (BB) muscle vulnerable to overuse injury. The aim of this study was to investigate whether there are differences in the amplitude of the EMG signal of the BB muscle during fast and spin delivery, during the seven phases of both types of bowling and the kinesiological interpretation of the bowling arm for muscle contraction mechanisms during bowling. A group of 16 male amateur bowlers participated in this study, among them 8 fast bowlers (FB) and 8 spin bowlers (SB).

c-Myc quadruplex-forming sequence Pu-27 induces extensive damage in both telomeric and nontelomeric regions of DNA.

Quadruplex-forming DNA sequences are present throughout the eukaryotic genome, including in telomeric DNA. We have shown that the c-Myc promoter quadruplex-forming sequence Pu-27 selectively kills transformed cells (Sedoris, K. C.

Toxic compounds in honey.

There is a wealth of information about the nutritional and medicinal properties of honey. However, honey may contain compounds that may lead to toxicity. A compound not naturally present in honey, named 5-hydroxymethylfurfural (HMF), may be formed during the heating or preservation processes of honey.

Effects of anthropometric variables and electrode placement on the SEMG activity of the biceps brachii muscle during submaximal isometric contraction in arm wrestling.

Surface electromyography (SEMG) has been widely used to analyze the biceps brachii (BB) muscle during voluntary contraction, and the effect of the interelectrode distance has been studied. However, the effect of anthropometric variations and the placement of electrodes on the BB activity during arm wrestling (i.e.

The first finding of chromosome variations in wild-born western hoolock gibbons.

Hoolock gibbons (genus Hoolock) are a group of very endangered primate species that belong to the small ape family (family Hylobatidae). The entire population that is distributed in the northeast and southeast of Bangladesh is estimated to include only around 350 individuals. A conservation program is thus necessary as soon as possible.

A review of Brucella seroprevalence among humans and animals in Bangladesh with special emphasis on epidemiology, risk factors and control opportunities.

Brucellosis is a neglected bacterial zoonotic disease in many countries affecting both humans and animals. The aim of this paper is to review published reports of the seroprevalence of brucellosis in humans and animals (cattle, buffalo, sheep, goats and dogs) in Bangladesh. The prevalence studies are based primarily on the following serological tests: rose bengal plate agglutination test (RBT), plate agglutination test (PAT), tube agglutination test (TAT), mercaptoethanol agglutination test (MET), standard tube agglutination test (STAT), slow agglutination test (SAT), milk ring test (MRT), indirect enzyme-linked immunosorbant assay (I-ELISA), competitive ELISA (C-ELISA) and fluorescent polarization assay (FPA).

Male rats transmit Brucella abortus biotype 1 through sexual intercourse.

The aim of this study was to evaluate transmission of Brucella abortus biotype 1 via sexual intercourse in rats. Male and female virgin Sprague-Dawley (SD) rats were experimentally infected intraperitoneally with 1×10(9)colony forming units (CFU) of B. abortus biotype 1, a Korean bovine isolate.

Mechanomyogram for muscle function assessment: a review.

Background: Mechanomyography (MMG) has been extensively applied in clinical and experimental practice to examine muscle characteristics including muscle function (MF), prosthesis and/or switch control, signal processing, physiological exercise, and medical rehabilitation. Despite several existing MMG studies of MF, there has not yet been a review of these. This study aimed to determine the current status on the use of MMG in measuring the conditions of MFs.