Pain management in cardiothoracic practice.

All analgesia regimens have benefits and side effects, and personal expertise can greatly influence the efficacy of regional techniques. A multimodal approach to analgesic management allows physicians to achieve maximum analgesic efficacy while limiting side effects. An appropriate analgesic plan takes into account the extent of pain associated with the type of incision and adjusts this according to each patient's individual needs.

Auditory P50 in schizophrenics on clozapine: improved gating parallels clinical improvement and changes in plasma 3-methoxy-4-hydroxyphenylglycol.

Schizophrenic patients have decreased inhibition of the P50 auditory evoked potential response to the second of two paired click stimuli delivered 500 ms apart. This deficit in inhibitory gating does not change during treatment with typical neuroleptics. We recently reported that neuroleptic-resistant schizophrenics had enhanced P50 gating after 1 month of clozapine treatment, if they responded with decreased clinical symptoms.

On the nature and scope of featural representations of word meaning.

Behavioral experiments and a connectionist model were used to explore the use of featural representations in the computation of word meaning. The research focused on the role of correlations among features, and differences between speeded and untimed tasks with respect to the use of featural information. The results indicate that featural representations are used in the initial computation of word meaning (as in an attractor network), patterns of feature correlations differ between artifacts and living things, and the degree to which features are intercorrelated plays an important role in the organization of semantic memory.

Inhibitory gating of an evoked response to repeated auditory stimuli in schizophrenic and normal subjects. Human recordings, computer simulation, and an animal model.

Background: Altered sensory response is a prominent feature of schizophrenia. Inhibitory gatting mechanisms, shown by diminished P50 evoked responses to repeated auditory stimuli, seem to be deficient in schizophrenic persons. These inhibitory mechanisms usually are studied by averaging the electroencephalographic responses to many presentations of pairs of stimuli.

Gating of auditory P50 in schizophrenics: unique effects of clozapine.

Schizophrenic patients have a deficit in the ability to filter sensory stimuli, which can be demonstrated in several psychophysiological paradigms. For example, most unmedicated schizophrenic subjects fail to decrement the P50 auditory evoked response to the second of paired stimuli, when the interstimulus interval is 500 msec. This sensory gating deficit persists in schizophrenics treated with typical antipsychotics, even if they show significant clinical improvement.

Volumetric capnography in children. Influence of growth on the alveolar plateau slope.

Background: Lung growth in children is associated with dramatic increases in the number and surface area of alveolated airways. Modelling studies have shown the slope of the alveolar plateau (phase III) is sensitive to the total cross-sectional area of these airways. Therefore, the influence of age and body size on the phase III slope of the volumetric capnogram was investigated.

Nonword pronunciation and models of word recognition.

Nonword pronunciation is a form of generalization behavior that has been at the center of debates about models of word recognition, the role of rules in explaining behavior, and the adequacy of the parallel distributed processing approach. An experiment yielded data concerning the pronunciation of a large corpus of nonwords. The data were then used to assess 2 models of naming: a model developed by D.

Simple developmental speech delay: a follow-up study.

The authors followed 38 children with delayed speech development approximately two to four years after initial diagnosis, assessing and comparing their subsequent speech and language, and over-all development. Nearly all of the children had appropriate language levels for their general development. Just over half had less articulation competence than expected for their age, but this was not related to language achievement or age.

Haemolysis during in vitro CO2 removal from human blood using a membrane lung.

Haemolysis of human blood has been examined in vitro as a function of pH in the range 7.2-8.0.

A randomized comparison of total extracorporeal CO2 removal with conventional mechanical ventilation in experimental hyaline membrane disease.

Apnoeic oxygenation (AO) combined with extracorporeal CO2 removal (ECCO2R), using venovenous perfusion across a membrane area of 0.1 m2 has been shown to be feasible in six healthy anaesthetized rabbits. In a further twelve rabbits, ECCO2R has been randomly compared with conventional mechanical ventilation (CMV) following saline lavage to induce respiratory failure.

Relationship of Yield and Pratylenchus spp. Population Densities in Superior and Russet Burbank Potato.

Number of Pratylenchus spp. (primarily P. penetrans) were recorded at planting in experimental potato plots over a 9-year period at one location on Prince Edward Island.

The effect of different totals and ratios of dietary calcium and phosphorus on the performance and incidence of leg abnormalities of male and female broiler chickens.

A factorial experiment involving 1,404 day-old Shaver broiler chicks (702 of each sex) assessed the effects of total calcium (Ca) and available phosphorus (AP) and their ratio (Ca: AP) during the starter (0 to 21 days) and finisher (22 to 42 days) periods on general performance, tibia strength, tibia ash, Ca and P content of tibia ash, tibia dyschondroplasia, twisted legs, and total leg abnormalities. Nine starter and nine finisher diets were used with the percentage Ca and AP ranging from .98 to 1.

The forensic pediatrician as a child advocate.

This paper focuses on the medicolegal activities of a group of six pediatricians from the Winnipeg Children's Hospital. Increasing legal demands resulted in 93 court appearances for the group, during a 12-month period ending in December 1982. The educational processes and the individual court room issues confronted by both the courts and the six pediatricians, dealing with problems of child protection, are described.

Child abuse in Winnipeg: hospital and community together.

The Winnipeg Children's Hospital Child Protection Centre program for helping physically, sexually and emotionally abused children and their families is presented. The Protection Centre strongly advocates and works within a multidisciplinary approach which includes the hospital, child welfare agencies, the police and the justice system in case management and in carrying out intervention strategies and treatment plans. This approach is considered a most effective means of ensuring the care and protection of children.

The Winnipeg Children's Hospital child protection centre: a provincial medical initiative.

The Winnipeg Children's Hospital child protection centre is a hospital-based provincial protection program that focuses on the diagnosis, treatment and prevention of child abuse and neglect in Manitoba. The multidisciplinary group of professionals working in the centre differs from most hospital-based teams in that it has a strong government liaison both functionally and financially, has strong ties to the welfare system and has legal counsel relating to the court system. The centre represents the philosophy that medical participation in welfare matters relating to children need not be relegated to the sidelines.

The effect of feed denial in starter diets on the performance of broiler chickens.

A total of 2000 commercial chickens (1000 males and 1000 females) were used in an exploratory experiment designed to estimate the effect of two daily feed denial treatments (8 and 12 hr) extended from either 8 to 21 days or 15 to 28 days of age. Mortality was unaffected by these treatments. Body weight at 28 days was reduced, and feed conversion was improved by the feed denial treatments.

The effect of crumbled and pelleted feed on the incidence of sudden death syndrome among male chicken broilers.

An experiment involving 7200 male broiler chickens was conducted to estimate the effect of feeding crumble-pellet diets on the incidence of Sudden Death Syndrome (SDS). Mortality due to SDS was significantly higher for birds fed a crumble-pellet regimen in its usual form or in a ground form compared with birds fed all-mash diets. Birds fed the crumble-pellet dietary regimen grew more rapidly than those on either the ground crumble-pellet regimen or on all-mash.

Effect of vitamins on the incidence of mortality and acute death syndrome ("flip-over") in broiler chickens.

Eight different vitamin mixtures were each fed to 6 replicate pens (150 birds/pen) of day-old Cobb chicks in a completely randomized design to evaluate the effect of biotin, pyridoxine, and thiamine singly or in combination and the effect of feeding these vitamins in addition to the standard vitamins at two and four times their required level on mortality and incidence of acute death syndrome (ADS) or "flip-over" of broiler chickens. Further additions of the standard vitamins and the addition of thiamine to the standard vitamin mixture significantly (P less than .05) increased 28-day live weights.