Impact of COVID-19 Pandemic on Trauma CT Imaging.

Purpose: The goal of this study was to understand the impact of COVID-19 pandemic and associated lockdown measures on the volume, rate, and type of trauma presenting to the emergency department (ED) by using trauma-initiated CT studies to capture patient data.

Materials And Methods: We performed a retrospective observational study comparing patients undergoing CT scans for trauma during the 1 and 2 lockdown periods compared to corresponding prepandemic months. During two lockdown periods, public places such as restaurants, libraries, parks, and shops across the province were shut down.

Effects of two pesticides on northern leopard frog (Lithobates pipiens) stress metrics: Blood cell profiles and corticosterone concentrations.

Amphibians are declining globally. Exposure to pesticides has been implicated in decreasing amphibian immune function, thus increasing their susceptibility to parasites and disease and thereby negatively affecting individuals and populations. Amphibians are likely exposed to neonicotinoids because these widely used insecticides are highly soluble in water and because amphibian freshwater habitats are often embedded in agroecosystems.

Effects of 2 Neonicotinoid Insecticides on Blood Cell Profiles and Corticosterone Concentrations of Wood Frogs (Lithobates sylvaticus).

Neonicotinoids are widely used insecticides that are detectable in agricultural waterways. These insecticides are of concern due to their potential impacts on nontarget organisms. Pesticides can affect development of amphibians and suppress the immune system, which could impact disease susceptibility and tolerance.

Estrogens, inflammation and cognition.

The effects of estrogens are pleiotropic, affecting multiple bodily systems. Changes from the body's natural fluctuating levels of estrogens, through surgical removal of the ovaries, natural menopause, or the administration of exogenous estrogens to menopausal women have been independently linked to an altered immune profile, and changes to cognitive processes. Here, we propose that inflammation may mediate the relationship between low levels of estrogens and cognitive decline.

Single-dose etomidate is not associated with increased mortality in ICU patients with sepsis: analysis of a large electronic ICU database.

Objective: Retrospective analyses of several trials suggest etomidate may be unsafe for intubation in patients with sepsis. We evaluated the association of etomidate and mortality in a large cohort of septic patients to determine if single-dose etomidate was associated with increased in-hospital mortality.

Design And Setting: Retrospective cohort study at the Philips eICU Research Institute ICU clinical database.

Attenuation of the cortisol response to stress in female rainbow trout chronically exposed to dietary selenomethionine.

Selenomethionine (Se-Met) is the major dietary form of selenium (Se). While Se is a required nutrient, it can also influence the physiological stress response because it stimulates greater concentrations of cortisol in blood plasma of exposed fish. However, little is known about the effects of exposure to Se on the ability to cope with a secondary stressor.

Quantitative assessment of elemental carbon in the lungs of never smokers, cigarette smokers, and coal miners.

Inhalation exposure to particulates such as cigarette smoke and coal dust is known to contribute to the development of chronic lung disease. The purpose of this study was to estimate the amount of elemental carbon (EC) deposits from autopsied lung samples from cigarette smokers, miners, and control subjects and explore the relationship between EC level, exposure history, and the extent of chronic lung disease. The samples comprised three subgroups representing never smokers (8), chronic cigarette smokers (26), and coal miners (6).

Increased myoepithelial cells of bronchial submucosal glands in fatal asthma.

Background: Fatal asthma is characterised by enlargement of bronchial mucous glands and tenacious plugs of mucus in the airway lumen. Myoepithelial cells, located within the mucous glands, contain contractile proteins which provide structural support to mucous cells and actively facilitate glandular secretion.

Objectives: To determine if myoepithelial cells are increased in the bronchial submucosal glands of patients with fatal asthma.

Nocardia farcinica pericarditis after kidney transplantation despite prophylaxis.

A deceased-donor kidney transplant recipient developed purulent pericarditis caused by Nocardia despite trimethoprim-sulfamethoxazole (TMP-SMX) prophylaxis for Pneumocystis jirovecii. She was treated empirically with ceftriaxone and amikacin and subsequently underwent sternotomy with drainage of an intrapericardial abscess. Culture and susceptibility data demonstrated Nocardia farcinica, which was susceptible to SMX and amikacin, although resistant to ceftriaxone.

Calcium antagonism in neonatal rats with kaolin-induced hydrocephalus.

Juvenile rats with kaolin-induced hydrocephalus have reduced brain injury if treated with nimodipine or magnesium sulfate. Experiments were conducted to determine if the neuroprotective effects could be replicated in neonatal rats with experimental hydrocephalus at an age comparable to prematurely born humans. In a blinded and randomized manner, drugs were administered for 14 days beginning 7 days after induction of hydrocephalus.

Age differences in visual search for traffic signs during a simulated conversation.

The effects of divided attention were examined in younger adults (M = 23 years) and older adults (M = 64 years) who searched for traffic signs in digitized images of traffic scenes. Sign search was executed under single-task and dual-task conditions in scenes containing either small or large amounts of visual clutter. For both age groups, clutter and the secondary task had additive effects on search accuracy, speed, and oculomotor involvement.

Varied-mapping conjunction search: evidence for rule-based learning.

Five experiments were carried out to examine whether top-down processes can aid search, even when targets and distractors are variably mapped. Experiments 1a and 1b determined that effortless VM search can be obtained in Contrast Polarity X Orientation and Color X Orientation conjunction search when one feature dimension remains consistently mapped across blocks. Experiment 2 showed that efficient VM search is possible when both dimensions are variably mapped.

Modulation of locomotor activity by multiple 5-HT and dopaminergic receptor subtypes in the neonatal mouse spinal cord.

Recently, it has been shown that bath-applied 5-HT can elicit fictive locomotion from perinatal mouse preparations. Since 5-HT acts on multiple receptor subtypes, the focus of this study was to examine which receptor families contribute to the genesis and modulation of locomotor activity. Blockade of 5-HT(2) (ketanserin or N-desmethylclozapine) or 5-HT(7) receptors (SB-269970) could reversibly block or modulate the locomotor-like pattern.

Molecular phylogenetic evidence for the evolution of specialization in anemonefishes.

Anemonefishes (genera: Amphiprion and Premnas; family Pomacentridae) are a group of 28 species of coral reef fishes that are found in obligate symbiosis with large tropical sea anemones. A phylogenetic hypothesis based on morphological analyses of this group suggests that the ancestral anemonefish was a generalist with similar morphology to other pomacentrids, and that it gave rise to other anemonefish species that were more specialized for living with particular species of host anemones. To test this hypothesis we constructed a molecular phylogeny for the anemonefishes by sequencing 1140 base pairs of the cytochrome b gene and 522 base pairs of the 16S rRNA gene for six species of anemonefishes (representatives of all subgenera and species complexes) and two other pomacentrid species.

Focal myasthenia gravis in a dog.

A 10-month-old American cocker spaniel was evaluated for megaesophagus, aspiration pneumonia, but no appendicular muscle weakness. During hospitalization, weakness of the facial muscles developed, this resolved with anticholinesterase administration. Serum antibodies against acetylcholine receptors were documented, confirming the diagnosis of focal myasthenia gravis.

The postingestive consequences of fat condition preferences for flavors associated with high dietary fat.

To investigate whether children acquire conditioned preferences for flavors associated with high dietary fat content, 27 3- and 4-year-old children participated in a series of 12 conditioning or mere exposure sessions. Following an overnight fast, children who participated in conditioning trials consumed fixed quantities of a flavored yogurt drink that on half the days was high in fat and energy (954 kJ, 18 g fat/150 g serving) or contained no fat (277 kJ, 0 g fat/150 g serving). Children in the conditioning group consumed 150 g servings, children in the mere exposure group tasted 16 g or less of these same stimuli.

Children's lunch intake: effects of midmorning snacks varying in energy density and fat content.

To determine the effects of preloads differing in energy density and fat content on subsequent lunch intake, 24 preschool children consumed 113 g ice-cream preloads as mid-morning snacks (containing 0, 12, or 18 g of fat, and 4 g of protein), followed nearly 2 h later by an ad libitum lunch consisting of a variety of foods. A fat-free baseline preload, consisting of dry cereal and apple juice, was also included. The baseline, fat-free, medium and high-fat preloads contained 334, 740, 953, and 1150 kJ per serving.

An appliance based approach to the management of palatopharyngeal incompetency: a clinical pilot project.

The palatal lift appliance has been described in the dental literature for more than 30 years, yet its efficacy remains controversial in the management of palatopharyngeal incompetency during speech. A pilot project was undertaken to develop a clinical research protocol. In the pilot project, 32 patients had palatopharyngeal incompetency managed with a palatal lift appliance.

Conditioned preferences: young children prefer flavors associated with high dietary fat.

In two experiments, 20 2-5-year-old children participated in a series of 8 conditioning trials to investigate whether they acquired conditioned preferences based on the fat content of a food. On different days, each child consumed fixed quantities of novelly flavored yogurts that were high or low in fat and energy density (220 or 110 kcal/serving). After conditioning, patterns of ad lib consumption data provided evidence of caloric compensation in response to the energy density differences in the preloads.

Conditioned flavor preferences in young children.

In this experiment 11 children participated in a series of 8 pairs of conditioning trials in order to investigate the hypothesis that children could form conditioned flavor preferences based on caloric density. Unfamiliar drink flavors were used in these trials, and the drinks were either high in caloric density (155 kcal/150 ml) or low (less than 5 kcal/150 ml). Caloric density was altered by the addition of low glucose maltodextrin.

Conditioned meal initiation in young children.

In two experiments the conditioning of meal initiation was investigated. Preschool children ate snacks repeatedly in the presence of visual and auditory cues (CS+). On other days, other visual and auditory cues (CS-) were presented in the absence of food.

Children's food intake following drinks sweetened with sucrose or aspartame: time course effects.

In two experiments, 2-5-year-old children's responsiveness to caloric density cues was examined. In a preloading protocol, consumption of fixed volumes of drinks (205 ml in Experiment 1; 150 ml in Experiment 2), sweetened with sucrose, aspartame, aspartame plus low glucose maltodextrin, or a water control, was followed by ad lib consumption from among a variety of foods. Caloric drinks had about 90 kcal in Experiment 1, 65 kcal in Experiment 2.

What kind of exposure reduces children's food neophobia? Looking vs. tasting.

To determine the relative effectiveness of two different types of exposure on young children's preference for initially novel foods, 51 two- to five-year-old children received either "look" or "taste" exposures to seven novel fruits. Foods were exposed five, 10 or 15 times, and one food remained novel. Following the exposures, children made two judgments of each of the 21 pairs: one based on looking, the other on tasting the foods.