Canadian medical schools before ACMC.

The earliest medical schools were established to supplement apprenticeship, the only route to practice available in colonial Canada. By 1885, eight medical schools were trying to accommodate the volume of new scientific information flowing from Europe. In 1910, when Flexner evaluated the schools against the Johns Hopkins model, some were woefully deficient, but by 1928 all had achieved Class A rating.

Intermediary metabolism in diabetic dogs treated with pancreatic autotransplants and insulin pumps.

Diurnal metabolite profiles were studied in pancreatectomized dogs who had received grafts of their own pancreas. The results were compared to similarly diabetic animals who received exogenous insulin pumped intravenously either peripherally or portally. All animals were studied at least 52 weeks after pancreatectomy.

Metabolic control in diabetic dogs treated with pancreatic autotransplants and insulin pumps.

Fasting metabolite and hormonal levels were studied prospectively in pancreatectomized dogs who had received grafts of their own pancreas. The results were compared with similarly diabetic animals who received exogenous insulin pumped intravenously either peripherally or portally. All animals were studied for 48-91 wk after pancreatectomy.

Glycemic control in diabetic dogs treated with pancreatic autotransplants and insulin pumps.

The restoration of metabolic control in diabetes mellitus is predicated upon the uniform achievement of fasting euglycemia. In the absence of fasting normoglycemia, metabolic control is fundamentally compromised. We asked whether the currently experimental methods of treating experimental diabetes are capable of achieving normality in this regard.

Pancreatic autotransplantation.

Segmental pancreatic autotransplantation is successful in our hands if blood flow through the splenic artery is enhanced by either a jump graft or a distal fistula, and if these technical manoeuvres are supplemented by anticoagulation. We found the jump method of arterial anastomosis was the most successful. Perfusion of the isolated graft is not necessary, and may even be harmful.

PRURITUS AND JAUNDICE.

The records of 147 patients who had pruritus and jaundice (11% of a series of 1262 patients with jaundice) were reviewed in an effort to delineate more clearly the etiology of jaundice associated with pruritus.Fifty-two had obstructive jaundice caused by neoplasm, 51 had obstructive jaundice not caused by neoplasm, 42 had pruritus associated with hepatogenous jaundice, and two had jaundice and pruritus associated with a lymphoma.Pruritus occurred in 17% of all patients with non-neoplastic obstructive jaundice and in 45% of patients with neoplastic obstructive jaundice.

A CHEAP, EFFECTIVE GASTRIC COOLING APPARATUS FOR THE CONTROL OF GASTROINTESTINAL HEMORRHAGE.

Gastric cooling (as opposed to freezing) is a useful adjunct in the management of upper gastrointestinal hemorrhage. Commercial machines for this purpose are expensive. A simple system is described in which cooled tap water is circulated through an extragastric reservoir, using an applicator modified slightly from the original design described by Wangensteen.