Publications by authors named "McNair W"
The off-label use of an intravenous dexmedetomidine infusion is an option for refractory symptoms in pediatric palliative care with a few published cases of in-home use, most limited to end-of-life care. After an intrathecal baclofen pump malfunction with meningitis and medication withdrawal, a 17-year-old adolescent with quadriparetic cerebral palsy and paroxysmal autonomic instability experienced relief of refractory pain and dystonia with an in-home intravenous dexmedetomidine infusion. His interdisciplinary care team collaborated to establish safety measures and adjust his home medication regimen to further improve quality of life well before his end of life.
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- The study aimed to understand how the SCN5A sodium ion channel is involved in dilated cardiomyopathy (DCM) and its implications for arrhythmias.
- Researchers analyzed genetic samples from 289 DCM families, identifying five unique SCN5A mutations, three of which were novel.
- A significant 93% of mutation carriers experienced arrhythmias, indicating a strong link between SCN5A mutations and arrhythmic conditions, with potential implications for clinical diagnosis and treatment.
This article explores the emotional and reflective journey of registered nurse Wendy McNair in her role as a mentor. This personal account illuminates her awareness of what makes a good mentor and how the role influences the student's perioperative experience. The information shared in this article has been extracted from her reflective portfolio created during a recent mentorship course at Edge Hill University (Manchester).
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- A family with a hereditary cardiac conduction disorder exhibited symptoms like sinus node dysfunction and heart dilation, linked to a specific region on chromosome 3.
- Researchers screened the SCN5A gene, identifying a significant mutation (D1275N) present in all affected family members but absent in healthy controls.
- This discovery suggests that sodium channel genes may play a role in cardiac dilation and dysfunction, broadening the understanding of related heart conditions.
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- A study involving 66 patients with angina at rest used exercise electrocardiography, thallium scintigraphy, and coronary arteriography to assess coronary artery disease.
- The results showed that while exercise electrocardiography was very predictive (93%) of coronary artery disease, it had low sensitivity (52%).
- Thallium scintigraphy demonstrated similar predictive ability (91%) but was much more sensitive (91%), particularly benefiting patients with inconclusive exercise electrocardiograms lacking Q waves.