Pectin-gelatin complex coacervates I: Determinants of microglobule size, morphology, and recovery as water-dispersible powders.

The pectin-gelatin complex coacervate system was evaluated and characterized. The effects of final pH, mixing pH, colloid ratio, and solution concentration were investigated. A recovery procedure yielding microglobules of a controlled and uniform size in dry powder form which were readily revertible in water to a polydispersed suspension was developed.

An evaluation of minocycline in patients with periodontal disease.

The purpose of this study was to determine the passage into and concentration of Minocycline HCl (Minocin) in gingival crevicular fluid (GCF) and the relationship between its concentration of saliva. GCF, serum and changes in periodontal health. Over an 8 day period, 10 adults with periodontal disease received orally 200 mg/day of Minocin and 10 other received 150 mg/day.

Analysis of compression of frequency chirped optical pulses by a strongly dispersive grating pair.

An optical pulse compression medium formed by two parallel gratings can be strongly dispersive if the diffracted beam emerges at grazing angle from the surface of the first grating. Strong dispersion makes possible temporal compression of broad incident pulses. However, sufficiently strong dispersion is accompanied by a nonlinear variation of group delay with carrier frequency, which will cause the envelope of the compressed pulse to be distorted and limit the minimum attainable pulse width.

Characteristics of medicated and unmedicated microglobules recovered from complex coacervates of gelatin-acacia.

Medicated and unmedicated microglobules prepared from complex coacervates of Type A gelatin and acacia were recovered as water-insoluble powders consisting of discrete units, which were spontaneously revertible to highly disperse systems when suspended in water or physiological electrolyte solutions. Spherical microglobules containing up to 15% (w/w) sulfamerazine had a nominal diameter of 30 micron in aqueous suspension. Larger but irregularly shaped products containing up to 45% (w/w) sulfamerazine were also recovered.

O-Demethylation of p-nitroanisole by Escherichia coli. Stimulation by phenobarbital.

Intact cells of the bacterium Escherichia coli ATCC 11229, can convert p-nitroanisole into p-nitrophenol. The presence of phenobarbital in the culture medium during growth of the cells results in an inhibition of bacterial cell mass and an increased ability of the bacterial cell to carry out the O-demethylation reaction. There was a linear relationship between the amount of product formed and the bacterial cell mass in the incubation mixture.

Interactions of chlorphenesin and divalent metal ions with phosphodiesterase.

Chlorphenesin inhibition of the hydrolysis of cyclic AMP by guinea-pig lung phosphodiesterase was reversed by the addition of exogenous magnesium ions. Chlorphenesin and theophylline inhibition of this enzyme was shown to be noncompetitive when the substrate concentration was low. Kinetic studies of the inhibition of beef heart phosphodiesterase by chlorphenesin and theophylline indicated that the substrate concentration was a factor in determining whether inhibition was competitive or noncompetitive.

Hexachlorophene metabolism in rats: the hepatic route.

The terminal elimination rate of radioactivity from the bile of bile-duct cannulated rats, that had received hexachlorophene-14C via the hepatic portal vein, had an apparent first-order half-life of about 10 hr. Tissue distribution studies in these rats indicated that 35-47% of the carbon-14 of the dose was eliminated through the bile within 24 hr. Significant amounts of radioactivity were also found in the liver and carcass at that time; the brain was the only tissue that did not consistently have much higher concentrations of carbon-14 than the blood.

The influence of a high level of corn oil on rat serum lipoproteins.

Although the stated requirement for linoleic acid in humans is less than 2% of the dietary calories, recently there has been considerable emphasis on the necessity to substitute dietary polyunsaturates for saturates in order to reduce serum cholesterol levels. In this study we have sought to determine the nutritional consequences of feeding a very high level of linoleate to rats. Three groups of thirty adult animals each were fed a semipurified diet consisting by weight of casein 17%; mineral mixture 5.

Effect of exercise on tissue lipids and serum lipoproteins of rats fed two levels of fat.

Adult rats were fed a low fat (4%) or a high fat (40%) diet, and groups of other rats selected for good running were fed these two diets and were treadmill exercised 5 days a week for 6 weeks. The serum triglycerides were significantly lower in exercised rats fed the low fat diet, but not in those fed the high fat diet, as compared with corresponding controls. The liver lipids were vastly elevated in sedentary rats fed the high fat diet as compared with those fed the low fat diet.