A Solitary Fibrofolliculoma in Close Proximity to the Medial Canthus.

Fibrofolliculomas are benign connective tissue tumours of the hair follicle that typically present as multiple lesions over the head and neck. A solitary fibrofolliculoma is a rare entity and has not been previously described in the canthal region. The authors report an unusual case of a 43-year-old female who was found to have a solitary fibrofolliculoma located in close proximity to the medial canthus following an excision biopsy.

Sub-regional analysis of the parotid glands: model development for predicting late xerostomia with radiomics features in head and neck cancer patients.

Background: The irradiation of sub-regions of the parotid has been linked to xerostomia development in patients with head and neck cancer (HNC). In this study, we compared the xerostomia classification performance of radiomics features calculated on clinically relevant and de novo sub-regions of the parotid glands of HNC patients.

Material And Methods: All patients ( = 117) were treated with TomoTherapy in 30-35 fractions of 2-2.

Assessing the generalisability of radiomics features previously identified as predictive of radiation-induced sticky saliva and xerostomia.

Background And Purpose: While core to the scientific approach, reproducibility of experimental results is challenging in radiomics studies. A recent publication identified radiomics features that are predictive of late irradiation-induced toxicity in head and neck cancer (HNC) patients. In this study, we assessed the generalisability of these findings.

Gender-related and geographic trends in interactions between radiotherapy professionals on Twitter.

Background And Purpose: Twitter presence in academia has been linked to greater research impact which influences career progression. The purpose of this study was to analyse Twitter activity of the radiotherapy community around ESTRO congresses with a focus on gender-related and geographic trends.

Materials And Methods: Tweets, re-tweets and replies, here designated as , around the ESTRO congresses held in 2012-2021 were collected.

Predicting radiotherapy-induced xerostomia in head and neck cancer patients using day-to-day kinetics of radiomics features.

Background And Purpose: The images acquired during radiotherapy for image-guidance purposes could be used to monitor patient-specific response to irradiation and improve treatment personalisation. We investigated whether the kinetics of radiomics features from daily mega-voltage CT image-guidance scans (MVCT) improve prediction of moderate-to-severe xerostomia compared to dose/volume parameters in radiotherapy of head-and-neck cancer (HNC).

Materials And Methods: All included HNC patients (N = 117) received 30 or more fractions of radiotherapy with daily MVCTs.

Trauma-Informed Pedagogy to Foster Resilience in Graduate Nursing Education.

The experiences of graduate nursing students during the COVID-19 pandemic necessitate a trauma-informed approach to education. Three hundred graduate nursing students responded to a discussion assignment in a doctoral-level health care policy course. Thematic analysis identified common themes of fear, anxiety, frustration, and exhaustion ( n = 93).

Phase 1 study of safety, tolerability and immunogenicity of the human telomerase (hTERT)-encoded DNA plasmids INO-1400 and INO-1401 with or without IL-12 DNA plasmid INO-9012 in adult patients with solid tumors.

Background: Human telomerase reverse transcriptase (hTERT) is frequently classified as a 'universal' tumor associated antigen due to its expression in a vast number of cancers. We evaluated plasmid DNA-encoded hTERT as an immunotherapy across nine cancer types.

Methods: A phase 1 clinical trial was conducted in adult patients with no evidence of disease following definitive surgery and standard therapy, who were at high risk of relapse.

Intradermal SynCon® Ebola GP DNA Vaccine Is Temperature Stable and Safely Demonstrates Cellular and Humoral Immunogenicity Advantages in Healthy Volunteers.

Background: Nonlive vaccine approaches that are simple to deliver and stable at room temperature or 2-8°C could be advantageous in controlling future Ebola virus (EBOV) outbreaks. Using an immunopotent DNA vaccine that generates protection from lethal EBOV challenge in small animals and nonhuman primates, we performed a clinical study to evaluate both intramuscular (IM) and novel intradermal (ID) DNA delivery.

Methods: Two DNA vaccine candidates (INO-4201 and INO-4202) targeting the EBOV glycoprotein (GP) were evaluated for safety, tolerability, and immunogenicity in a phase 1 clinical trial.

Marginal structural model to evaluate the association between cumulative osteoporosis medication and infection using claims data.

Unlabelled: Due to the suboptimal persistence to osteoporosis (OP) treatment, factors triggering treatment discontinuation/switching may be causing time-varying confounding. BP treatment was associated with the risk of overall infection in opposite directions in the unweighted Cox model versus the weighted MSM. The discrepancy of effect estimates for overall infection in the MSM suggested there may be time-varying confounding.

One Size Care Does Not Fit All Patients Undergoing a Spinal Fusion.

Purpose: Spinal fusion (SF) surgery is a complex procedure that affects children with and without underlying disabilities. The purpose of this article was to describe the necessary steps when preparing a child, specifically with cerebral palsy (CP), and family for an SF, while also emphasizing the postoperative care during discharge planning.

Design: Literature review on pediatric patients undergoing SF and those who have CP.

A rare skin adnexal gland tumour of the eyelid.

We report a rare and atypical skin adnexal tumour of the eyelid. We highlight this condition for clinicians who treat periocular neoplasia.

Use of mini-monoka stents for punctal/canalicular stenosis.

Background: Proximal lacrimal system stenosis may cause debilitating epiphora and recurrent ocular infections. Mini-monoka stents are primarily used in the management of canalicular lacerations. Evidence regarding their use to treat punctal/canalicular stenosis is sparse.

Orbital augmentation with injectable calcium hydroxylapatite for correction of postenucleation/evisceration socket syndrome.

Purpose: To demonstrate the utility of injectable calcium hydroxylapatite (Radiesse) for orbital volume augmentation to correct postenucleation/evisceration socket syndrome (PESS).

Methods: A retrospective chart review of all consecutive patients in our practice who received injectable calcium hydroxylapatite placed in the extraconal space to augment orbital volume was conducted. Patients with at least 6 months follow-up were included in the study.

Stereolithographic models to guide orbital and oculoplastic surgery.

Purpose: This paper aims to highlight the potential of stereolithographic models (SLM) as a tool in orbital surgical planning, and provides four examples of their role in facilitating successful surgery.

Method: Retrospective case series report.

Results: Case 1: SLM facilitated a successful orbital biopsy of a deep orbital mass by allowing several practice trucut biopsies.

Osteoplasty using calcium hydroxylapatite filler.

Purpose: To describe a novel method using injectable calcium hydroxylapatite (Radiesse) for aesthetic correction of small bony defects in the skull.

Methods: A prospective, small interventional case series was performed. Three patients were identified with bony defects of the frontal bone from prior trauma or surgery.

Upper eyelid myectomy in blepharospasm with associated apraxia of lid opening.

Purpose: To assess the impact of upper eyelid myectomy surgery on blepharospasm with associated apraxia of lid opening (ALO), dry eye, photophobia, and daily functioning in patients who are refractory to botulinum toxin treatment.

Design: Noncomparative, consecutive, interventional case series.

Methods: A retrospective chart review was performed to identify 100 consecutive patients beginning on January 1, 2000, who underwent upper eyelid myectomy surgery for blepharospasm and fulfilled the inclusion criteria.

Injectable calcium hydroxylapatite for orbital volume augmentation.

Objective: To describe a new method of augmenting orbital volume for anophthalmic enophthalmos correction.

Methods: A retrospective medical record review was conducted of 4 consecutive patients who had injectable calcium hydroxylapatite (Radiesse) placed in the extraconal space to augment orbital volume.

Results: Four patients were treated with 1 to 2 vials (1.