Response to Comment on "Pushing the frontiers of density functionals by solving the fractional electron problem".

Gerasimov . claim that the ability of DM21 to respect fractional charge (FC) and fractional spin (FS) conditions outside of the training set has not been demonstrated in our paper. This is based on (i) asserting that the training set has a ~50% overlap with our bond-breaking benchmark (BBB) and (ii) questioning the validity and accuracy of our other generalization examples.

Pushing the frontiers of density functionals by solving the fractional electron problem.

Density functional theory describes matter at the quantum level, but all popular approximations suffer from systematic errors that arise from the violation of mathematical properties of the exact functional. We overcame this fundamental limitation by training a neural network on molecular data and on fictitious systems with fractional charge and spin. The resulting functional, DM21 (DeepMind 21), correctly describes typical examples of artificial charge delocalization and strong correlation and performs better than traditional functionals on thorough benchmarks for main-group atoms and molecules.

Effect of Heavy Resisted Sled Sprint Training During the Competitive Season on Sprint and Change-of-Direction Performance in Professional Soccer Players.

Purpose: Resisted sled sprinting (RSS) is an effective tool for improving sprint performance over short distances, but the effect on change-of-direction (COD) performance is largely unknown. The present study investigated the effect of heavy RSS training during the competitive season on sprint and COD performance in professional soccer players.

Methods: Over 6 wk in-season, an RSS training group (n = 6) performed RSS at a sled load of 30% body mass for a total program running distance of 800 m, whereas an unresisted sprint (URS) training group (n = 7) performed the same distance of unresisted sprinting.

In vitro model of attachment of Giardia intestinalis trophozoites to IEC-6 cells, an intestinal cell line.

Attachment of giardias to intestinal cells has been difficult to study because of a lack of a convenient in vitro model. We developed an assay for attachment of radiolabeled trophozoites to IEC-6 cells that can be done in microtiter trays. Attachment was confirmed by scanning and transmission electron microscopy.

Modulation of epidermal growth factor-induced cell proliferation and receptor binding by insulin in cultured intestinal epithelial cells.

The effect of insulin on EGF-induced cell proliferation and on modulation of EGF receptors was examined in IEC-6 cells in culture. Insulin-induced cell proliferation was not seen until concentration of the hormone reached the microgram (10 micrograms/ml) level, producing an increase in EGF receptor binding affinity (Ka 8.2 +/- .