Mayo Clinic Tapestry Study: A Large-Scale Decentralized Whole Exome Sequencing Study for Clinical Practice, Research Discovery, and Genomic Education.

Objective: To execute a large-scale, decentralized, clinical-grade whole exome sequencing study, coined Tapestry, for clinical practice, research discovery, and genomic education.

Patients And Methods: Between July 1, 2020, and May 31, 2024, we invited 1,287,608 adult Mayo Clinic patients to participate in Tapestry. Of those contacted, 114,673 patients were consented and 98,222 (65.

Deposition of Nanometric Polymer-Surfactant Complexes Formed by Cationic Dextran: A Path to Sustainable Formulations.

The home and personal care industry is evolving toward more sustainable and environmentally friendly ingredients. Rinse-off personal care products rely on formation of polymer-surfactant complexes to drive deposition of benefit agents (e.g.

Predicting Bubble Fragmentation in Superfluids.

In classical fluids, the Weber number is a dimensionless parameter that characterizes the flow of a multiphase fluid. The superfluid analogy of a classical multiphase fluid can be realized in a system of two or more immiscible Bose-Einstein condensates. These superfluid mixtures have been shown to display a wider variety of exotic dynamics than their single component counterparts.

Spatio-temporal breather dynamics in microcomb soliton crystals.

Solitons, the distinct balance between nonlinearity and dispersion, provide a route toward ultrafast electromagnetic pulse shaping, high-harmonic generation, real-time image processing, and RF photonic communications. Here we uniquely explore and observe the spatio-temporal breather dynamics of optical soliton crystals in frequency microcombs, examining spatial breathers, chaos transitions, and dynamical deterministic switching - in nonlinear measurements and theory. To understand the breather solitons, we describe their dynamical routes and two example transitional maps of the ensemble spatial breathers, with and without chaos initiation.

One Health in Medical Education: A Proposed Framework.

The One Health concept focuses on the interconnections between human health, animal health, and the environment, stressing the need for interdisciplinary collaborations to address complex issues such as the health challenges posed by climate change and global pandemics. One Health is a central part of the curriculum of veterinary schools, however, it is rarely incorporated into medical school education. Nationally, there are limited examples of formal One Health education and training for medical students.

Scalable stable comb-to-tone integrated RF photonic drive for superconducting qubits.

The recent advent of quantum computing has the potential to overhaul security, communications, and scientific modeling. Superconducting qubits are a leading platform that is advancing noise-tolerant intermediate-scale quantum processors. The implementation requires scaling to large numbers of superconducting qubits, circuit depths, and gate speeds, wherein high-purity RF signal generation and effective cabling transport are desirable.

Effect of Age-Friendly Communities Action Plan on Trajectories of Older Canadians' Depressive Symptoms Between 2018 and 2020: Multilevel Results From the Canadian Longitudinal Study on Aging.

As the COVID-19 pandemic impacted mental health, this longitudinal study examined the effect of age-friendly communities (AFC) action plan on older adults' depressive symptoms. Using the CLSA, the CLSA COVID-19 Questionnaire study, survey of Canadian municipalities, and the census, the depressive symptoms trajectories were modeled with multilevel multinomial regressions. Most respondents (66.

The changing landscape of both causes and locations of death in a regional HIV population 2010-2021.

Background: Although HIV-related deaths among people with HIV have dramatically decreased, deaths from other medical conditions and non-medical events have increased. The location of death among people with HIV remains underreported.

Objectives: We reviewed the deaths, causes of death, and reported location of death (i.

A bibliometric and systematic review of the Methods for the Improvement of Vulnerability Assessment in Europe framework: A guide for the development of further multi-hazard holistic framework.

Unlabelled: Conceptual frameworks are vital for identifying relevant components, dimensions and indicators to assess vulnerability to natural hazards and climatic change. Given the fact that vulnerability is applied and used in various disciplines and by multiple schools of thought, several conceptual frameworks to assess and conceptualise vulnerability have been developed. Even though these frameworks have been widely cited in research, the range and context of application and contextual use of such frameworks have rarely been explored.

The Effects of Cognitive Ability, Mental Health, and Self-Quarantining on Functional Ability of Older Adults During the COVID-19 Pandemic: Results From the Canadian Longitudinal Study on Aging.

Objectives: Determine whether levels of anxiety and depression, cognitive ability, and self-quarantining during and prior to the pandemic predict decreases in perceived functional ability.

Design And Setting: Longitudinal data collected from the Canadian Longitudinal Study on Aging (CLSA) COVID-19 Questionnaire Study (2020) and core CLSA study (Follow-Up 1; 2014-2018).

Participants: 17 541 CLSA participants.

The impact of loneliness and social isolation during COVID-19 on cognition in older adults: a scoping review.

Background: The COVID-19 pandemic required implementation of public health measures to reduce the spread of SARS CoV-2. This resulted in social isolation and loneliness for many older adults. Loneliness and social isolation are associated with cognitive decline, however, the impact of this during COVID-19 has not been fully characterized.

COVID-19 vaccine uptake among people with HIV: identifying characteristics associated with vaccine hesitancy.

People with HIV (PWH) are at increased risk of COVID-19 infection. Both Canadian (NACI) and US (CDC) guidelines recommend that all PWH receive at least 2 doses of COVID-19 vaccine, and a booster. We examined vaccination uptake among PWH in Southern Alberta, Canada.

Feasibility study on a longer side-alternating vibration therapy protocol (15 min per session) in children and adolescents with mild cerebral palsy.

Objective: Previous studies on side-alternating vibration therapy (sVT) have usually used a 9 min intervention protocol. We performed a feasibility study aimed at assessing the safety, acceptability, and potential effectiveness of a longer sVT protocol (15 min per session) in children and adolescents with cerebral palsy (CP).

Methods: Fifteen participants aged 5.