Publications by authors named "McLaren R"

A decision analysis model was constructed for comparison of early detection of asymptomatic genital chlamydial infection in women by the direct immunofluorescence antibody (DFA) test and the enzyme-linked immunosorbent assay (ELISA) with no intervention. Early-detection programs using the DFA test and ELISA were shown to be cost-effective in female populations where the prevalences of chlamydial infection exceeded 6% and 7%, respectively. Sensitivity analysis showed that the two most important factors were the probability of developing pelvic inflammatory disease and the cost of the test.

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Repetitive extragenic palindromic (REP) sequences are highly conserved inverted repeats present in up to 1000 copies on the Escherichia coli chromosome. We have shown both in vivo and in vitro that REP sequences can stabilize upstream mRNA by blocking the processive action of 3'----5' exonucleases. In a number of operons, mRNA stabilization by REP sequences plays an important role in the control of gene expression.

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In a series of 14 dogs, fractures of both tibiae were caused by a "bone-breaker" designed in the authors' department and observed to produce a consistent and realistic canine fracture. One tibia was plated with a carbon fiber reinforced plastic (CFRP) plate and the other with a dynamic compression (DC) plate. Roentgenographic examination demonstrated healing of the CFRP-plated tibiae with abundant callus, and almost total remodeling of the fracture callus between ten and 20 weeks.

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There are complications of spinal cord paralysis peculiar to the extended care period. These may be motor skeletal, neurogenic, visceral and psychogenic. If practised regularly, prevention can be very effective in reducing the disability in all groups.

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Subjects were timed as they made judgments about ps and qs (also interpretable as ds and bs) in different angular orientations. Whether these judgments were left-right mirror-image discriminations (b vs. d or p vs.

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In Experiment 1, subjects performed a mental-rotation task in which they were timed as they decided whether rotated letters were normal or backwards. Between presentations of the letters, they watched a rotating textured disk that induced an aftereffect of rotary movement on the letters. The function relating reaction times to orientation was influenced asymmetrically by the aftereffect, suggesting that perceived movement interacts with imagined movement.

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A system was evaluated of measuring Pao2 and Pao2 by an inline sensor in the brachial artery and gas chromatography. Eight patients having coronary artery vein grafts were studied during anaesthesia, operation, perfusion and for 24 hours afterward. Compared to conventional blood gas analysis by polarography (electrodes), the chromatographic method gave readings for Pao2 which were not significantly different during normothermia.

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We report unusually high concentrations of free fatty acids and glycerol in sera of patients with adult-onset diabetes, and the accompanying alterations in creatine kinase isoenzyme MM patterns associated with such patients. The serum samples with increased free fatty acids also showed increased electrophoretic movement of the MM isoenzyme on cellulose acetate membranes. Fatty acid concentrations found in such samples averaged 9.

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Four local anaesthetic solutions (2% carbonated lignocaine with or without adrenaline and 0.5% bupivacaine HCl with or without adrenaline) were used randomly for 335 continuous lumbar extradural blocks in labour. Carbonated lignocaine caused a more rapid onset of analgesia than bupivacaine HCl.

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