Publications by authors named "McLaren R"

Due to complex interactions, changes in any one area of food systems are likely to impact-and possibly depend on-changes in other areas. Here we present the first annual monitoring update of the indicator framework proposed by the Food Systems Countdown Initiative, with new qualitative analysis elucidating interactions across indicators. Since 2000, we find that 20 of 42 indicators with time series have been trending in a desirable direction, indicating modest positive change.

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Objective:  In recent years, the management of placenta accreta spectrum (PAS) has fallen into two categories: planned hysterectomy and conservative management to preserve fertility. However, optimal management remains unclear. Therefore, we conducted a systematic review and meta-analysis comparing the two to evaluate which approach was associated with lower surgical morbidity.

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Article Synopsis
  • Alkuraya-Kučinskas syndrome (AKS) is a rare genetic disorder caused by mutations in the BLTP1 gene, leading to various serious developmental issues such as brain malformations, joint contractures, and clubfeet.
  • A case study highlights two new mutations associated with AKS, showcasing severe anomalies in a fetus, including hydrops and brainstem kink, alongside a literature review of 19 other cases that provides insights into common prenatal features.
  • The review indicates that many AKS cases present significant symptoms like joint contractures, brain issues, and facial abnormalities, stressing the importance of genetic testing for diagnosis when such features are observed in a fetus.
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Objective: To assess the effect of propranolol on time to delivery among patients undergoing induction or augmentation of labor.

Data Sources: PubMed, Scopus, Cochrane Library, ClinicalTrials.gov, and CINAHL (EBSCO) were searched from inception to December 2023.

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Background: Treatment options for severe, refractory iron deficiency anemia are limited in pregnancy.

Objective: To review the available literature on the use of recombinant erythropoietin in the treatment of iron deficiency anemia in pregnancy.

Search Strategy: An electronic search of seven databases from inception to March 2022 was performed using a combination of keywords.

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Background: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-linked recessive disorder that predisposes individuals to hemolysis due to an inborn error of metabolism. We performed a systematic literature review to evaluate G6PD deficiency as a possible etiology of nonimmune hydrops fetalis (NIHF) and severe fetal anemia.

Methods: PubMed, OVID Medline, Scopus, and clinicaltrials.

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Background: Intrahepatic cholestasis of pregnancy has been linked to sudden stillbirth. The suddenness of the stillbirths in these cases have led clinicians to suspect that the pathogenesis of stillbirth in women with intrahepatic cholestasis of pregnancy is not related to asphyxia but rather to an undefined etiology. One leading hypothesis relates certain bile acid metabolites to myocardial injury.

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Objective: This was a systematic review and meta-analysis comparing maternal and neonatal outcomes of patients screened with the 1-step or 2-step screening method for gestational diabetes mellitus.

Data Sources: PubMed, Scopus, Cochrane, ClinicalTrials.gov, and LILACS were searched from inception up to September 2022.

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Objective: To evaluate if antenatal steroid use was associated with a lower rate of respiratory complications in neonates born late preterm to patients with pregestational diabetes mellitus (PGDM).

Methods: This was a retrospective cohort study of live, singleton, non-anomalous, late preterm births complicated by PGDM using data from the Centers for Disease Control and National Vital Statistics System from 2017 to 2021. The primary (assisted ventilation use >6 h) and secondary neonatal outcomes (immediate assisted ventilation, Apgar score, neonatal intensive care unit [NICU] admission, and surfactant use) were compared between births that received steroids and those that did not.

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Haptic nudging via wearable devices promotes physical activity and may increase upper limb movement in stroke rehabilitation. This study investigated the optimal approach to haptic nudging by examining diurnal variation, duration of effect, and repeated nudging. The study analysed data from a multiple-period randomised crossover study.

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Article Synopsis
  • The analysis introduces a food system indicator framework and monitoring architecture to assess food system changes related to global development and sustainability goals, focusing on five key themes: diets and health, environmental impact, livelihoods and equity, governance, and resilience.
  • A total of 50 indicators were developed through a consultative process, ensuring coverage for each theme, which serves as a baseline for evaluating global food systems.
  • While every country shows positive outcomes in certain areas, no country excels across all domains, indicating room for improvement towards achieving healthy, sustainable, and equitable food systems by 2030.
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Article Synopsis
  • The study aimed to assess the significance of PIEZO1 gene variants found through prenatal exome sequencing in cases of non-immune hydrops fetalis (NIHF).
  • A systematic review of studies from 2000 to 2022 identified 36 relevant articles, leading to an analysis of 22 pregnancies with 35 unique PIEZO1 variants.
  • Findings indicated that PIEZO1 variants were diagnosed in 10% of NIHF cases, establishing it as the most frequently identified single gene involved in this condition, with variants categorized as either dominant or recessive.
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Objective: To describe the maternal outcomes of a prospective cohort of non-immune hydrops fetalis (NIHF) pregnancies with negative standard-of-care evaluations.

Methods: This study was a secondary analysis of a prospective cohort study of NIHF pregnancies with negative work-ups (infection, alloimmune anemia, fetomaternal hemorrhage, and chromosomal disorders). Outcomes were obstetric complications, including pre-eclampsia, mirror syndrome, preterm birth, polyhydramnios, postpartum hemorrhage, and maternal mental health.

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Objective:  The objective of this study was to assess the exposure to minimally invasive gynecologic surgery (MIGS) techniques among senior (third and fourth year) Obstetrics and Gynecology residents in the United States.

Methods:  We conducted an online cross-sectional survey among senior residents who completed a 19-item questionnaire regarding their exposure to laparoscopic and robotic cases and techniques and their access to their simulation. We performed a comparison among these residents, grouped based on the four geographical regions of the United States.

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Objective: To describe prenatal and postnatal imaging findings of fetal adrenal hemorrhage (FAH) and its associated perinatal outcomes, including frequency of postnatal surgical intervention.

Method: A systematic literature review of seven electronic databases was conducted from inception until January 2022, with 2008 articles identified reporting prenatally identified fetal adrenal masses. Studies with confirmed FAH diagnosis were included.

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Background: Imposter syndrome is a chronic feeling of doubt leading to a sense of incompetence, which is common among trainees. However, little is known about the effect of gender on imposter syndrome among surgical trainees.

Methods: An online national survey was distributed to the surgical subspecialty residents between March and September 2022, including demographics, validated Clance Imposter Scale and a short questionnaire evaluating depression and anxiety.

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Incarcerated gravid uterus (IGU) is a serious complication of pregnancy that leads to adverse obstetric outcomes. The aim of this review was to describe this entity in detail. We also aimed to understand if pregnancies with predisposing risk factors that increase the risk of developing IGU had a difference in their clinical manifestations, treatment, and obstetric outcomes.

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The ARRIVE (A Randomized Trial of Induction Versus Expectant Management) trial demonstrated lower rates of hypertensive disorders of pregnancy (HDP) among low-risk nulliparous patients undergoing labor induction at 39 weeks of gestation. We conducted a population-based cohort study in which we evaluated the association between the routinization of 39-week induction and the rate of HDP by comparing rates before and after the ARRIVE trial publication, using the National Vital Statistics System. Logistic regression models were used to project what the HDP rate would have been based on trends seen pre-ARRIVE.

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We report here two large studies investigating the effects of an established transcranial direct current stimulation (tDCS) procedure on perceptual learning as indexed by the face inversion effect. Experiments 1a and 1b (n = 128) examined the harmful generalization from Thatcherized faces to normal faces by directly comparing the size of the inversion effect for normal faces when presented intermixed with Thatcherized faces (Experiment 1a) versus that obtained when normal faces were presented intermixed with checkerboards (Experiment 1b). The results from the sham/control tDCS groups provide the first direct evidence in the literature showing how Thatcherized faces generalize onto normal ones producing a reduced inversion effect compared to when normal faces are presented with stimuli (e.

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Objective: To highlight the possibility of genetic discrimination in the United States with respect to carrier screening under limitations of the Genetic Information Nondiscrimination Act (GINA) and to encourage providers to educate patients about this possibility during pretest counseling.

Methods: Review of current professional guidelines and practice resources regarding the necessary components of pretest counseling for carrier screening in the context of GINA's limitations and the potential impact of carrier screening results on life, long-term care and disability insurance.

Results: Current practice resources advise that patients in the United States should be informed that their employer or health insurance company generally cannot use their genetic information during the underwriting process.

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Objective: Noisy galvanic vestibular stimulation (nGVS) has been used to facilitate vestibular function and improve gait and balance in people with poor postural control. The aim of this scoping review is to collate, summarize and report on the nGVS parameters that have been used to augment postural control.

Method: A systematic scoping review was conducted up to December 2022.

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Objective: We performed a systematic review to evaluate the clinical presentation and maternal and fetal outcomes in pregnancies with early-onset HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome.

Data Sources: PubMed, Ovid MEDLINE, Scopus, CINAHL, Cochrane Library, and ClinicalTrials.gov were queried from inception through January 1, 2023 with the following terms: "HELLP syndrome," "HELLP," "hemolysis, elevated liver enzymes, low platelets," "hemolysis, elevated liver enzymes, low platelets syndrome," "pre-viable," "peri-viable," "previable," "periviable," "first trimester," "second trimester," "before 23 weeks," "<23 weeks," "<23 week gestation," and "before 23 weeks gestation.

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Objectives: We evaluated differences in vaccination rates of patients of teaching and private practices, and explored the rate of vaccine hesitancy in pregnant women.

Methods: This was a cross-sectional study of a convenience sample of recently delivered women. Women completed a survey, which included a question about whether they received the influenza and/or Tdap vaccine, and a vaccine hesitancy scale for both influenza and Tdap vaccines.

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