Publications by authors named "McLaren E"

Article Synopsis
  • Despite advances in AI, drug development remains expensive and complicated; the introduction of F.O.R.W.A.R.D presents a network-based approach to prioritize drug targets, specifically for Inflammatory Bowel Diseases.
  • F.O.R.W.A.R.D uses machine learning on clinical trial transcriptomic data to create a molecular signature for remission and accurately predicts how drugs might influence remission-related genes, achieving 100% accuracy in trials involving 52 targets.
  • The approach shows potential to enhance trial design, encourage re-evaluation of previously failed drugs, and adapt to different therapeutic areas, ultimately aiming to reshape drug discovery and clinical decision-making.
View Article and Find Full Text PDF

Schwartz Centre Rounds are designed to support staff to reflect on the social and emotional aspects of working in healthcare. Providing healthcare in highly pressurised environments is a common climate in which many healthcare professionals find themselves. To deliver the very best care to patients, both clinical and non-clinical members of the workforce need to be supported to reflect, share their experiences and have a safe space in which they can be heard safely.

View Article and Find Full Text PDF

Intraspecific and habitat-mediated responses to chemical cues play key roles in structuring populations of marine species. We investigated the behaviour of herbivorous-stage juvenile crown-of-thorns sea stars (COTS; sp.) in flow-through choice chambers to determine if chemical cues from their habitat influence movement and their transition to become coral predators.

View Article and Find Full Text PDF

Subtropical reefs host a dynamic mix of tropical, subtropical, and temperate species that is changing due to shifts in the abundance and distribution of species in response to ocean warming. In these transitional communities, biogeographic affinity is expected to predict changes in species composition, with projected increases of tropical species and declines in cool-affinity temperate species. Understanding population dynamics of species along biogeographic transition zones is critical, especially for habitat engineers such as sea urchins that can facilitate ecosystem shifts through grazing.

View Article and Find Full Text PDF

Background: Anti-MDA5 (Melanoma differentiation-associated protein-5) positive dermatomyositis (MDA5-DM) is characterised by rapidly progressive interstitial lung disease (ILD) and high mortality. MDA5 is an RNA sensor and a key pattern recognition receptor for the SARS-CoV-2 virus.

Methods: This is a retrospective observational study of a surge in MDA5 autoimmunity, as determined using a 15 muscle-specific autoantibodies (MSAs) panel, between Janurary 2018 and December 2022 in Yorkshire, UK.

View Article and Find Full Text PDF

Statement Of Problem: Natural teeth are graded in terms of translucency and strength. Graded zirconia materials are now available with a higher yttria content on the top or in the enamel zone to increase surface translucency and a lower yttria content on the bottom or in the dentin zone to increase strength. Such materials could provide multiple advantages over uniform materials and reduce the need for porcelain veneering in anterior artificial crowns; however, studies on the properties of these materials are lacking.

View Article and Find Full Text PDF

Background: Anti-MDA5 (Melanoma differentiation-associated protein-5) positive dermatomyositis (MDA5 -DM) is characterised by rapidly progressive interstitial lung disease (ILD) and high mortality. MDA5 senses single-stranded RNA and is a key pattern recognition receptor for the SARS-CoV-2 virus.

Methods: This is a retrospective observational study of a surge in MDA5 autoimmunity, as determined using a 15 muscle-specific autoantibodies (MSAs) panel, between Janurary 2018-December 2022 in Yorkshire, UK.

View Article and Find Full Text PDF

Objectives: Although the presence of a chairside CAD/CAM system in the dental office saves time and cost, it deprives the dentist from the dental technologist' skills and experience. The dentist now has to gain and acquire knowledge and skills about how to finish, characterize, stain, and glaze ceramic restorations. The main objectives of this article is to teach novel and reproducible techniques for surface color, texture, glaze and polish for either the chairside or laboratory fabricated indirect ceramic restoration.

View Article and Find Full Text PDF

Temporomandibular disorders (TMDs) are a prevalent but complex group of conditions that cause orofacial pain. Temporomandibular disorders are recognized as one of the most common chronic pain conditions, alongside back pain and headache disorders. Given the competing theories surrounding what causes TMDs and limited high-equality evidence on optimally treating TMDs, clinicians often encounter challenges in developing an effective management plan for patients.

View Article and Find Full Text PDF

Objectives: To compare the effects of particle abrasion medium and pressure on shear bond strength and biaxial flexural strength of three generations of zirconia (Lava Frame, Lava Plus, and Lava Esthetic) with the goal of optimizing the bond to zirconia.

Methods: 280 discs (14 mm diameter; 1 mm thickness) of each zirconia were milled and sintered. Specimens of each material were randomly distributed into 14 groups (n=20); half were tested for shear bond strength and half were tested for biaxial flexural strength.

View Article and Find Full Text PDF

Smile design is an ongoing challenge in both dentistry and facial cosmetics surgery. Herein, some very common smile design scenarios are shared with six world known masters. Each case will be reviewed by 2 cosmetic dentists, 2 periodontists, and 2 oral and maxillofacial surgeons.

View Article and Find Full Text PDF

Aims: To evaluate About Face, a pain management program aimed at increasing quality of life in adults living with persistent facial pain through psychology- and physiotherapy-based skill development.

Methods: A total of 90 patients attended a six-session program with a 1-month follow-up between 2015 and 2019. Patients filled out self-reported outcome measures preprogram, postprogram, and at a 1-month follow-up visit.

View Article and Find Full Text PDF

Difunctionalization of strained cyclic alkynes presents a powerful strategy to build richly functionalized cyclic alkenes in an expedient fashion. Herein we disclose an efficient and flexible approach to achieve carbohalogenation, dicarbofunctionalization, aminohalogenation and aminocarbonation of readily available cyclohexenyl triflates. We have demonstrated the novel use of zincate base/nucleophile system for effective formation of key cyclohexyne intermediates and selective addition of various carbon and nitrogen nucleophiles.

View Article and Find Full Text PDF

Statement Of Problem: Newly developed translucent zirconia materials have been used for anterior monolithic complete coverage restorations. Surface treatments can improve adhesion, as well as decrease or increase the strength of ceramics. However, information on the influence of surface treatments on the strength of translucent zirconias is sparse.

View Article and Find Full Text PDF

Objectives: This study aimed to compare the color and fluorescence of five dentin ceramic systems with human dentin to enhance shade matching.

Materials And Methods: Five dentin ceramic systems, including Vita, GC, Creation, Noritake, and Ivoclar in 16 shades, and 12 human dentins, were prepared. The fluorescence and color coordinates were measured at 380-780 nm.

View Article and Find Full Text PDF

Growth rate represents a fundamental axis of life history variation. Faster growth associated with C photosynthesis and annual life history has evolved multiple times, and the resulting diversity in growth is typically explained via resource acquisition and allocation. However, the underlying changes in morphogenesis remain unknown.

View Article and Find Full Text PDF

Given increasing longevity worldwide, older adults and caregivers are seeking ways to curb cognitive decline especially for those with mild cognitive impairment (MCI, now mild neurocognitive disorder, mNCD, Diagnostic and Statistical Manual of Mental Disorders, 5th ed. (DSM-V). This quasi-experimental, within-subjects pilot clinical trial was designed to replicate and extend the study of cognitive benefits for MCI by improving upon our prior interactive Physical and Cognitive Exercise Study (iPACES v1.

View Article and Find Full Text PDF

Esthetic or cosmetic dentistry has become one of the main areas of dental practice emphasis and growth for the past several decades. Many articles have been written and courses taught over the years on concepts of smile design to develop a treatment plan for an esthetic outcome for the patient. The beauty of digital smile design is that patients can see the potential esthetic outcomes of treatment options in minutes.

View Article and Find Full Text PDF

Debunking common medicare myths can help providers guide patients through complicated post-acute care coverage.

View Article and Find Full Text PDF

Statement Of Problem: Three mol% yttria-stabilized tetragonal zirconia polycrystal (3Y-TZP) possesses excellent mechanical properties but is relatively opaque. Five mol% yttria-stabilized zirconia polycrystal (5Y-ZP) offers improved translucency, but many of its clinical properties have not been compared with those of 3Y-TZP and lithium disilicate.

Purpose: The purpose of this in vitro study was to compare the flexural strength, translucency parameter, bond strength, and enamel and material wear of 5Y-ZP (Katana UTML) with 3Y-TZP (Katana HT) and lithium disilicate (e.

View Article and Find Full Text PDF

Statement Of Problem: Bonded porcelain veneers are widely used esthetic restorations. High success and survival rates have been reported, but failures do occur. Fractures are the commonest failure mode.

View Article and Find Full Text PDF

Fabricating all-ceramic restorations with minimal or no application of a secondary phase while maintaining esthetics has been a sought-after goal of the dental profession. The objective has been development of a monolithic material with optical properties similar to the natural tooth without the need for layering porcelain. This article examines some of the newer cubic zirconia materials used in a monolithic form.

View Article and Find Full Text PDF

This article reviews the critical aspects of controlling the shade-taking environment and discusses various modalities introduced throughout the years to acquire and communicate shade information. Demonstrating a highly calibrated digital photographic technique for capturing shade information, this article shows how to use Photoshop® to standardize images and extract color information from the tooth and shade tab for use by a ceramist for an accurate shade-matching restoration.

View Article and Find Full Text PDF