Publications by authors named "McKenzie Stine"
Activated Protein Phosphatase 2A Disrupts Nutrient Sensing Balance Between Mechanistic Target of Rapamycin Complex 1 and Adenosine Monophosphate-Activated Protein Kinase, Causing Sarcopenia in Alcohol-Associated Liver Disease.
Gangarao Davuluri Nicole Welch Jinendiran Sekar Mahesha Gangadhariah Khaled Alsabbagh Alchirazi McKenzie Stine
Hepatology
May 2021
Article Synopsis
- The study investigates the effects of ethanol on skeletal muscle protein balance in alcohol-associated cirrhosis, focusing on how it disrupts signaling pathways like mTORC1 and AMPK.
- Ethanol leads to increased muscle autophagy by dephosphorylating mTORC1 while inhibiting AMPK, suggesting a complex interaction in energy regulation and muscle maintenance, termed a "pseudofed" state.
- The research identifies protein phosphatase 2A as a significant player in these processes and shows that altering the activity of PI3Kγ can help counteract the negative effects of ethanol on muscle signaling and function.