Topological Spin Textures in an Insulating van der Waals Ferromagnet.

Generation and control of topological spin textures constitutes one of the most exciting challenges of modern spintronics given their potential applications in information storage technologies. Of particular interest are magnetic insulators, which due to low damping, absence of Joule heating and reduced dissipation can provide energy-efficient spin-textures platform. Here, it is demonstrated that the interplay between sample thickness, external magnetic fields, and optical excitations can generate a prolific paramount of spin textures, and their coexistence in insulating CrBr van der Waals (vdW) ferromagnets.

Writing and Detecting Topological Charges in Exfoliated FeGeTe.

FeGeTe is a promising two-dimensional (2D) van der Waals (vdW) magnet for practical applications, given its magnetic properties. These include Curie temperatures above room temperature, and topological spin textures─TST (both merons and skyrmions), responsible for a pronounced anomalous Hall effect (AHE) and its topological counterpart (THE), which can be harvested for spintronics. Here, we show that both the AHE and THE can be amplified considerably by just adjusting the thickness of exfoliated FeGeTe, with THE becoming observable even in zero magnetic field due to a field-induced unbalance in topological charges.

Intra-Abdominal Actinomycosis: An Indolent Masquerader of Malignancy.

This report describes the case of a 54-year-old female who presented with the constitutional symptoms of lethargy, weight loss, and asthenia. She had been extensively investigated for possible gynaecological malignancy but with no definitive outcome achieved. The symptoms were persistent and, partly due to occurring during the coronavirus disease 2019 (COVID-19) pandemic, a decision was made to progress with surgical management.

Coexistence of Merons with Skyrmions in the Centrosymmetric Van Der Waals Ferromagnet Fe GeTe.

Fe GeTe is a centrosymmetric, layered van der Waals (vdW) ferromagnet that displays Curie temperatures T (270-330 K) that are within the useful range for spintronic applications. However, little is known about the interplay between its topological spin textures (e.g.

Treatment and Maintenance of Cutaneous Rosacea in Latino Skin Types With Prescription Medications and Non-Prescription Cleansers and Moisturizers as Adjuncts: A Review.

Background: Rosacea is an inflammatory dermatosis with at least a ten percent prevalence reported among white adults. Rosacea occurs in nonwhite populations, but prevalence data is limited.

Methods: Five dermatologists from Latin America (the panel) met virtually after completing a survey of their prescription and adjunctive therapy practices when managing Latin American patients with rosacea.

Effect of Multilayered Structure on the Static and Dynamic Properties of Magnetic Nanospheres.

The development of flexible and lightweight electromagnetic interference (EMI)-shielding materials and microwave absorbers requires precise control and optimization of core-shell constituents within composite materials. Here, a theoretical model is proposed to predict the static and dynamic properties of multilayered core-shell particles comprised of exchange-coupled layers, as in the case of a spherical iron core coupled to an oxide shell across a spacer layer. The theory of exchange resonance in homogeneous spheres is shown to be a limiting special case of this more general theory.

Magnetic nanoparticle modified electrodes for voltammetric determination of propellant stabiliser diphenylamine.

The overall aim of the work was to advance electrochemical devices capable of analysis of forensically relevant residues using rapid electrochemical sensor technology. In order to achieve this, electrochemical detection of the propellant stabiliser diphenylamine (DPA) was achieved via voltammetry with signal enhancement realised in the presence of iron oxide nanoparticle modified transducers. This allowed both mechanistic and analytical evaluation with the aim to achieve the required selectivity and sensitivity for reliable detection.

Availability of personal protective equipment among dermatologists in the COVID-19 pandemic: Assessment and risk factors in a web-based, global study.

Background: The availability of personal protective equipment (PPE) among dermatologists during the Coronavirus Disease 2019 (COVID-19) pandemic has not been studied.

Methods: We have assessed PPE availability among dermatologists and relevant aspects of hospital service by surveying 733 dermatologists.

Results: Considerable percentages of respondents had to purchase their own PPE (40.

Impact of COVID-19 pandemic on dermatology practices: Results of a web-based, global survey.

Unlabelled: The spectrum and magnitude of changes in dermatology practice induced by the COVID-19 pandemic have not been adequately studied.

Objective: This study aimed to assess the immediate and long-term effects of the pandemic on dermatology practice on a large scale, including the clinical activity of participants, frequency and types of procedures used, and teledermatology (TD) use.

Methods: This web-based, global survey included 733 dermatologists.

Dynamic Histological Events and Molecular Changes in Excisional Wound Healing of Diabetic DB/DB Mice.

Background: Wound contraction and re-epithelialization over the entire healing process had never been histologically examined daily in diabetic mouse wounds. Correlating morphological characters with molecular changes may be essential to understand the potential mechanism of impeded diabetic wound healing.

Materials And Methods: In 99 db/db and 63 db/m mice, dorsal-paired 8 mm-diameter wounds were created.

Dynamic susceptibility of concentric permalloy rings with opposite chirality vortices.

The high frequency dynamic behaviour of concentric permalloy nanorings with vortex domain structures with a thickness of 20 nm, a width in the range of 100 nm-250 nm, and a separation in the range of 10 nm-600 nm is investigated by micromagnetic simulations. The aim is to explore the ferromagnetic resonance of the concentric ring structure as a function of geometric parameters of the system. The dynamic susceptibility spectrum and spatial localization of the ferromagnetic resonance mode are investigated for varying ring widths and separations.

Time-resolved imaging of magnetic vortex dynamics using holography with extended reference autocorrelation by linear differential operator.

The magnetisation dynamics of the vortex core and Landau pattern of magnetic thin-film elements has been studied using holography with extended reference autocorrelation by linear differential operator (HERALDO). Here we present the first time-resolved x-ray measurements using this technique and investigate the structure and dynamics of the domain walls after excitation with nanosecond pulsed magnetic fields. It is shown that the average magnetisation of the domain walls has a perpendicular component that can change dynamically depending on the parameters of the pulsed excitation.

Results of a Phase 2 Efficacy and Safety Study with SB204, an Investigational Topical Nitric Oxide-releasing Drug for the Treatment of Acne Vulgaris.

Objective: To compare efficacy, tolerability, and safety of two concentrations of topical SB204 and vehicle twice daily for 12 weeks in the treatment of acne vulgaris.

Design: Randomized, double-blind, placebo-controlled, three-arm, Phase 2 study.

Setting: Dominican Republic, Panama, and Honduras.

Unexpected DNA affinity and sequence selectivity through core rigidity in guanidinium-based minor groove binders.

In this paper we report the design and biophysical evaluation of novel rigid-core symmetric and asymmetric dicationic DNA binders containing 9H-fluorene and 9,10-dihydroanthracene cores as well as the synthesis of one of these fluorene derivatives. First, the affinity toward particular DNA sequences of these compounds and flexible core derivatives was evaluated by means of surface plasmon resonance and thermal denaturation experiments finding that the position of the cations significantly influence the binding strength. Then their affinity and mode of binding were further studied by performing circular dichroism and UV studies and the results obtained were rationalized by means of DFT calculations.

Regulatory effects of introduction of an exogenous FGF2 gene on other growth factor genes in a healing tendon.

In this study of a tendon injury model, we investigated how injection of a vector incorporating one growth factor gene changes expression levels of multiple growth factor genes in the healing process. The flexor tendon of chicken toes was completely cut and repaired surgically. The tendons in the experimental arm were injected with an adeno-associated virus-2 vector incorporating basic fibroblast growth-factor gene, whereas the tendons in the control arm were not injected or injected with sham vectors.

Community representatives' involvement in Clinical and Translational Science Awardee activities.

Objectives: To understand the formal roles of community representatives (CRs) in Clinical and Translational Science Awardee (CTSA) activities, to evaluate the extent of integration into the organizational and governance structures and to identify barriers to effective integration.

Methods: The inventory tool was distributed to each of the 60 CTSAs using a secure web application.

Results: Forty-seven (78%) completed the inventory.

A community-based wellness program to reduce depression in African Americans: results from a pilot intervention.

Background: African Americans are less likely than non-Hispanic Whites to find antidepressants acceptable or seek care for depression.

Objective: To develop and pilot test a culturally tailored, community-based, psychoeducational wellness and exercise promotion program to reduce depressive symptoms in African Americans.

Methods: Participants were African Americans with moderate depressive symptoms who were interested in exercise but were not exercising regularly.

Aminoalkyl derivatives of guanidine diaromatic minor groove binders with antiprotozoal activity.

Considering the strong DNA minor groove binding observed for our previous series of diaromatic symmetric and asymmetric guanidinium and 2-aminoimidazolinium derivatives, we report now the synthesis of new aminoalkyl derivatives of diaromatic guanidines with potential as DNA minor groove binders and antiprotozoal activity. The preparation of these aminoalkyl derivatives (12a-e, 13a-e, 14a-c,e, 15a-e, 16a-e) is presented as well as their affinity for DNA which was evaluated by means of DNA thermal denaturation experiments. Finally, the antiprotozoal activity of most of these aminoalkyl minor groove binders was evaluated in vitro against Trypanosoma brucei rhodesiense (8 compounds) and Plasmodium falciparum (18 compounds).

Low-Radiation-Dose Modified Small Bowel CT for Evaluation of Recurrent Crohn's Disease.

Crohn's disease affects any part of the GI tract, commonly the terminal ileum. To decrease radiation exposure we developed a low-radiation-dose unenhanced CT (modified small Bowel CT, MBCT) to evaluate the small bowel using hyperdense oral contrast. Technique.

Ethics and community-based participatory research: perspectives from the field.

Exploring the importance of ethical issues in the conduct of community-based participatory research (CBPR) continues to be an important topic for researchers and practitioners. This article uses the Beyond Sabor Project, a CBPR project implemented in the Lower Rio Grande Valley, as a case example to discuss ethical issues such as the importance of increasing community involvement in research, ensuring that communities benefit from the research, sharing leadership roles, and sensitive issues regarding data collection and sharing. Thereafter, this article concludes with a brief discussion of six principles that can inform the practice of ethical conduct when implementing CBPR studies.

Do patients' communication behaviors provide insight into their preferences for participation in decision making?

Background: The Institute of Medicine report "Crossing the Quality Chasm'' encourages physicians to tailor their approaches to care according to each patient's individual preferences for participation in decision making. How physicians should determine these preferences is unclear.

Objective: The objective of this study is to assess whether judgments of patient communication behaviors, either globally or individually, can yield insight into patient preferences for participation in decision making.

Fracture risk remains reduced one year after discontinuation of risedronate.

Unlabelled: One year after discontinuation of three year's treatment with risedronate, BMD decreased at the lumbar spine and femoral neck and bone turnover markers returned to control group levels. Despite these changes, the risk of new morphometric vertebral fractures remained lower in previous risedronate patients compared with previous control patients.

Introduction: Differences in bisphosphonate pharmacology and pharmacokinetics could influence persistence or resolution of the effects once treatment is stopped.