Pandemic and student mental health: mental health symptoms among university students and young adults after the first cycle of lockdown in the UK.

Background: Early COVID-19 research suggests a detrimental impact of the initial lockdown on young people's mental health.

Aims: We investigated mental health among university students and young adults after the first UK lockdown and changes in symptoms over 6 months.

Method: In total, 895 university students and 547 young adults not in higher education completed an online survey at T1 (July-September 2020).

Gadolinium-based Contrast Agents Improve Detection of Recurrent Soft-Tissue Sarcoma at MRI.

Purpose: To determine the diagnostic efficacy of gadolinium-based contrast agents for the detection of recurrent soft-tissue sarcoma compared with non-contrast-enhanced conventional MRI sequences.

Materials And Methods: A retrospective study of patients with soft-tissue sarcomas who were imaged from January 2009 to December 2014 was performed. MRI studies from 69 patients (mean age, 61 years ± 15 [standard deviation], 45 men) with recurrent soft-tissue sarcoma and 63 age-, sex-, and tumor-matched controls with positive findings (nonrecurrence) were presented to six musculoskeletal radiologists at a tertiary cancer center in three image groupings.

Confidence Calibration: An Introduction With Application to Quality Improvement.

A probabilistic forecast is one that assigns a probability (or likelihood) to the occurrence of an event. Radiologists commonly make probabilistic judgments in their reports, even if these predictions are not explicitly expressed as numbers. There are calls for radiologists to commit to their probabilistic predictions in a standardized fashion; however, without a mechanism for feedback, there is no opportunity for improvement.

Performance of Risk Assessment Models for Peripartum Thromboprophylaxis.

Objective: There is no consensus on which risk stratification approach to use for thromboprophylaxis in pregnancy, and most available risk assessment models (RAMs) for venous thromboembolism (VTE) events have not been validated in pregnancy. Our objective was to compare the performance of some of the most commonly used VTEs RAMs in our patient population in the peripartum period.

Study Design: This is a retrospective cohort of women who delivered at our institution in 2015 and 2016.

Giant Cell Tumor of Cervical Spine Presenting as Acute Asphyxia: Successful Surgical Resection After Down-Staging With Denosumab.

Study Design: Case report and literature review.

Objective: To describe treatment of a unique case of acute airway obstruction by a large C7 giant cell tumor (GCT) with preoperative denosumab followed by surgical resection, and review the literature on this rare entity.

Summary Of Background Data: Standard treatment for GCTs includes surgical resection or curettage and packing.

Loss of Glis2/NPHP7 causes kidney epithelial cell senescence and suppresses cyst growth in the Kif3a mouse model of cystic kidney disease.

Enlargement of kidney tubules is a common feature of multiple cystic kidney diseases in humans and mice. However, while some of these pathologies are characterized by cyst expansion and organ enlargement, in others, progressive interstitial fibrosis and kidney atrophy prevail. The Kif3a knockout mouse is an established non-orthologous mouse model of cystic kidney disease.

Hedgehog signaling indirectly affects tubular cell survival after obstructive kidney injury.

Hedgehog (Hh) is an evolutionary conserved signaling pathway that has important functions in kidney morphogenesis and adult organ maintenance. Recent work has shown that Hh signaling is reactivated in the kidney after injury and is an important mediator of progressive fibrosis. Pericytes and fibroblasts have been proposed to be the principal cells that respond to Hh ligands, and pharmacological attenuation of Hh signaling has been considered as a possible treatment for fibrosis, but the effect of Hh inhibition on tubular epithelial cells after kidney injury has not been reported.

Coordinating patient care within radiology and across the enterprise.

For the practice of radiology, the transition to filmless imaging operations has resulted in a fundamental transition to more efficient clinical operations. In addition, the electronic delivery of diagnostic studies to the bedside has had a great impact on the care process throughout the health care enterprise. The radiology information system (RIS) has been at the core of the transition to filmless patient care.

miR-124 inhibits STAT3 signaling to enhance T cell-mediated immune clearance of glioma.

miRNAs (miR) have been shown to modulate critical gene transcripts involved in tumorigenesis, but their role in tumor-mediated immunosuppression is largely unknown. On the basis of miRNA gene expression in gliomas using tissue microarrays, in situ hybridization, and molecular modeling, miR-124 was identified as a lead candidate for modulating STAT3 signaling, a key pathway mediating immunosuppression in the tumor microenvironment. miR-124 is absent in all grades and pathologic types of gliomas.

miRNA-mediated immune regulation and immunotherapeutic potential in glioblastoma.

Glioblastoma (GB), the most common primary neoplasm of the CNS, remains universally fatal with standard therapies and has a mean overall survival time of only 14.6 months. Even in the most favorable situations most patients do not survive longer than 2 years.

A systematic analysis of cell cycle regulators in yeast reveals that most factors act independently of cell size to control initiation of division.

Upstream events that trigger initiation of cell division, at a point called START in yeast, determine the overall rates of cell proliferation. The identity and complete sequence of those events remain unknown. Previous studies relied mainly on cell size changes to identify systematically genes required for the timely completion of START.

Migration of central lines from the superior vena cava to the azygous vein.

Aim: To report 11 cases of central venous access catheters migrating from the superior vena cava to the azygos vein in order to raise radiologists' awareness of this possibility.

Materials And Methods: This is a retrospective review of the clinical history and imaging of 11 patients whose central line migrated from the superior vena cava to the azygos vein. The time course of migration, access route of the catheters, outcome, and depth of placement in the superior vena cava were evaluated.

The tumor microenvironment expression of p-STAT3 influences the efficacy of cyclophosphamide with WP1066 in murine melanoma models.

Melanoma is a common and deadly tumor that upon metastasis to the central nervous system (CNS) has median survival duration of less than 5 months. Activation of the signal transducer and activator of transcription 3 (STAT3) has been identified as a key mediator that drives the fundamental components of melanoma. We hypothesized that WP1066, a novel inhibitor of STAT3 signaling, would enhance the antitumor activity of cyclophosphamide (CTX) against melanoma, including disease within the CNS.

Comparison of half-dose and full-dose gadolinium MR contrast on the enhancement of bone and soft tissue tumors.

Objective: To evaluate the effect of half-dose intravenous gadolinium contrast on the enhancement of bone and soft tissue tumors.

Materials And Methods: This study is HIPAA compliant and informed consent was waived by the institutional review board. An institutional database search was performed over a 1-year period for patients with full- and half-dose MR examinations performed for musculoskeletal oncologic indications.

Early experience using an online reporting system for interventional radiology procedure-related complications integrated with a digital dictation system.

The absence of user-friendly systems for reporting complications is a major barrier to improving quality assurance (QA) programs in interventional radiology (IR) services. We describe the implementation of a QA application that is completely integrated with the radiology dictation system. We implemented an IR QA process as a module within the electronic medical record and radiologist dictation system applications used at our institution.

NCCN Task Force Report: Bone Health and Cancer Care.

Higher incidences of osteoporosis and osteopenia are found in cancer patients, particularly in women receiving aromatase inhibitors or with chemotherapy-induced ovarian failure, or in men with prostate cancer and androgen deprivation therapy. Therefore, management of long-term bone health is emerging as an important aspect of comprehensive cancer care. Patients with cancer typically have a number of additional risk factors for osteoporosis that should prompt screening, regardless of patient age or sex.

Cartilaginous lesions of the skeleton.

Cartilaginous lesions of the skeleton include those due to genetic diseases (skeletal dysplasias), reparative and hamartomatous processes, and benign and malignant tumors. We review the lesions most commonly encountered by the surgical pathologist, their differential diagnoses, and recently discovered features of these lesions.

Impact of multislice CT on PACS resources.

Multislice CT (MSCT), which allows for shorter scan times and thinner slice sections than single-slice helical CT (SSHCT), will likely increase the demands on picture imaging and communication system (PACS) resources. Weekly averages for number of images per study (IPS) were collected from MSCT and SSHCT scanners from 1-01 to 7-01. Average cycle times (ACT) and number of studies per patient (ANSPP) were analyzed from two MSCT and SSHCT scanners for the period of 1-1-00 to 4-1-01, and 4-1-01 to 8-1-01.

Enterprise utilization of "always on-line" diagnostic study archive.

To meet demands for enterprise image distribution, an "always on-line" image storage archive architecture was implemented before soft copy interpretation. It was presumed that instant availability of historical diagnostic studies would elicit a substantial utilization. Beginning November 1, 2000 an enterprise distribution archive was activated (Stentor, SanFrancisco, CA).

Evaluation of soft copy distribution of diagnostic studies before soft copy interpretation.

To meet the imaging needs of an expanding clinical campus and clinical volume, a web-based image distribution system (Stentor, San Francisco, CA) was implemented before the implementation of soft copy interpretation. This study sought to assess system utilization as a metric of system's capability to meet demand for enterprise image review. Study period included all examinations stored on the system and subsequently viewed from June 1, 2001 to August 8, 2001.

Implementing the DICOM Grayscale Standard Display Function for mixed hard- and soft-copy operations.

The aim of this work was to implement the DICOM Grayscale Standard Display Function (GSDF) at all stages of image presentation for computed radiography (CR) and direct digital radiography (DR) modalities. Cathode-ray tubes (CRT) were calibrated according to vendor procedures. Printer look-up-tables (LUT) were measured.

RadStation: client-based digital dictation system and integrated clinical information display with an embedded Web-browser.

RadStation is a digital dictation system having an integrated display of clinical information. The three-tiered system architecture provides robust performance, with most information displayed within one second after a request. The multifunctional client tier is a unique client/browser hybrid.

Integration of radiologist peer review into clinical review workstation.

Professional peer review of random prior radiologist's interpretations is mandated by the Joint Commission on Accreditation of Healthcare Organizations (JCAHO). The JCAHO expects documentation of 5% rate of random peer-review cases. Countless hours are spent in departments fulfilling these requirements.