Acceptance and Commitment Therapy Processes Differentially Predict Aspects of Mental Health.

Psychological flexibility relates to various aspects of mental health, including psychological distress and adaptive mental health. The CompACT has been developed to assess psychological flexibility by quantifying psychological flexibility as a multidimensional whole, and by three processes of psychological flexibility including, Openness to Experience (OE), Behavioral Awareness (BA), and Valued Action (VA). The current study examined the unique predictive property of each three process of the CompACT with aspects of mental health.

Inhibition of γ-secretase in adipocytes leads to altered IL-6 secretion and adipose inflammation.

Adipocyte-mediated inflammatory signalling has been proposed to alter adipose physiology in obesity and Type 2 diabetes mellitus. Novel targets for alteration of inflammatory signalling are needed to improve obesity-related outcomes. The γ-secretase enzyme complex has been suggested to play a role both in adipocyte function as well as in immune regulation.

Risk factors for congenital heart disease: The Baby Hearts Study, a population-based case-control study.

We investigated the role of maternal environmental factors in the aetiology of congenital heart disease (CHD). A population-based case-control study (242 CHD cases, 966 controls) was conducted using an iPad questionnaire for mother with linkage to maternity and first trimester prescription records. Risk of CHD was associated with low maternal education (OR adjusted for confounders 1.

The Baby Hearts Study - a case-control methodology with data linkage to evaluate risk and protective factors for congenital heart disease.

Introduction: The Baby Hearts study aimed to investigate risk and protective factors for congenital heart disease (CHD), and to investigate the health behaviours of a representative sample of pregnant women in Northern Ireland.

Objectives: We describe and evaluate the population-based case-control design enhanced with data linkage to administrative health data.

Methods: Cases (mothers of babies with CHD, n=286) were recruited following diagnosis prenatally or postnatally.

Detection and investigation of temporal clusters of congenital anomaly in Europe: seven years of experience of the EUROCAT surveillance system.

Detection and investigation of congenital anomaly clusters is one part of surveillance to detect new or changing teratogenic exposures in the population. The EUROCAT (European Surveillance of Congenital Anomalies) cluster monitoring system and results are described here. Monitoring was conducted annually from 2007 to 2013 for 18 registries covering an annual birth population up to 0.

Nose and vein, speed and pain: comparing the use of intranasal diamorphine and intravenous morphine in a Scottish paediatric emergency department.

Background: Urgent analgesia is essential for all children who present in severe pain, but difficulties in obtaining venous access can delay the use of adequate opiate analgesia. Intranasal diamorphine (IND) is now in use in around 60% of emergency departments and is the preferred choice of analgesia as reported by both parents and healthcare professionals. While IND has similar efficacy to intramuscular morphine in children, no study has compared its use against the current gold standard, intravenous morphine (IVM).

Performance of conventional and antimicrobial-treated filtering facepiece respirators challenged with biological aerosols.

This study evaluated the filtration performance of four commercially available models of National Institute of Occupational Safety and Health (NIOSH)-certified filtering facepiece respirators (FFR) against both biological and inert aerosols at a flow rate of 85 L/min. Conventional N95 and P100 FFRs and two antimicrobial (AM)-treated FFRs (an N95 and a P95, both with iodine-based AM treatments) were tested for both physical penetration (PEN(P)) and viable penetration (PEN(V)) with three different bioaerosols, including MS2 bacteriophage virus, and the spores and vegetative cells of Bacillus atrophaeus bacteria, in addition to inert sodium chloride (NaCl) aerosol. For each FFR model, the PEN(P) measured with NaCl was predictive of its MS2 PEN(P), and it was observed that spores and bacteria aerosols were also filtered similarly to the inert aerosol.

The health of children and young people with cerebral palsy: a longitudinal, population-based study.

Background: Cerebral palsy (CP) is a chronic condition about which little is known in relation to the long term stability of and factors influencing health.

Objectives: To describe the health status of 4-17 year olds with ambulant CP, compare with the general population and identify factors predicting change in health over time.

Design: A longitudinal, clinical survey.

Early MRI in the management of the clinical scaphoid fracture.

Objectives: The 'clinical scaphoid fracture' remains a common problem faced by emergency physicians. Early magnetic resonance imaging (MRI) has been used to routinely investigate such patients presenting to the emergency department of Aberdeen Royal Infirmary since 2002. The aim of this study was to evaluate the effectiveness of this strategy in the diagnosis of occult scaphoid fracture.

To what extent do children with cerebral palsy participate in everyday life situations?

The aims of the study are to describe participation of children with cerebral palsy in everyday life situations, to investigate the relationship between participation (primary outcome variable) with child and parent characteristics (independent variables) and to compare the frequency of participation (secondary outcome variable) of children with cerebral palsy with children without disabilities. A cross-sectional survey of parents of children with cerebral palsy in Northern Ireland was undertaken in families' homes using standard questionnaires. Children with cerebral palsy born between 31/8/1991 and 1/4/1997 were identified from a case register of people with the condition.

Elastomeric, half-facepiece, air-purifying respirator performance in a lead battery plant.

This workplace protection factor (WPF) study of a half facepiece air-purifying respirator with P100 filters was done in a lead battery manufacturing plant. Paired air samples for lead were collected inside and outside respirators worn by workers who were properly trained and quantitatively fit tested. Of the 45 valid sample sets, only four had detectable lead on the inside sample.

The health of children with cerebral palsy and stress in their parents.

Title: The health of children with cerebral palsy and stress in their parents.

Aim: This paper is a report of a study conducted to describe the health of children with cerebral palsy and investigate predictors of stress in their parents.

Background: Children with severe cerebral palsy tend to have poorer health than their able-bodied peers, and their parents are more likely to be stressed and have poorer health.

Psychological problems in children with hemiplegia: a European multicentre survey.

Objective: To describe the prevalence and determinants of psychological problems in European children with hemiplegia.

Design: Cross-sectional survey.

Setting: Home visits in nine European regions by research associates who administered standard questionnaires to parents.

Self-perception in overweight and obese children: a cross-sectional study.

Aim: The aim of this study was to examine the relationship between obesity and self-esteem in children in relation to specific domains of their self-perception, and further to explore the extent to which this may vary by gender and economic circumstances.

Method: A total of 211 children aged 8-9 years drawn from both advantaged and disadvantaged areas of Belfast completed the Harter Self-Perception Profile for Children and measures of body mass index were obtained.

Results: Overweight, impoverished children had significantly reduced social acceptance and physical competence scores.

Reliability and validity of the Child Health QuestionnairePF-50 for European children with cerebral palsy.

Objective: To evaluate the psychometric performance of the Child Health Questionnaire (CHQ) in children with cerebral palsy (CP).

Method: 818 parents of children with CP, aged 8-12 from nine regions of Europe completed the CHQ (parent form 50 items). Functional abilities were classified using the five-level Gross Motor Function Classification Scheme (Levels I-III as ambulant; Level IV-V as nonambulant CP).

Use of the child health questionnaire in children with cerebral palsy: a systematic review and evaluation of the psychometric properties.

Objective: To review the psychometric performance of the Child Health Questionnaire (CHQ) in samples of children with cerebral palsy (CP).

Method: Four search terms were applied to five databases in a search for papers published between 1993 and January 2007.

Results: A total of 13 papers were identified, providing data on 1229 unique children aged 2-18 years old.

CT lower extremity venography in suspected pulmonary embolism in the ED.

The purpose of this study was to evaluate the added benefit of computed tomography lower extremity venography (CTLV)--performed following CT pulmonary angiography (CTPA)--in the emergency department (ED) patient suspected of pulmonary embolism (PE). A retrospective review of 427 consecutive patients having both CTPA and CTLV performed to evaluate patients suspected of PE at two community hospitals was conducted. Three-month follow-up was performed on all patients to ensure that no case of PE or deep venous thrombosis (DVT) was missed.

A phase II trial of 6-hydroxymethylacylfulvene (MGI-114, irofulven) in patients with advanced non-small cell cancer previously treated with chemotherapy.

Purpose: To test the efficacy and safety of the novel antitumor agent MGI-114 (NSC 683863) in patients with advanced non-small cell lung cancer (NSCLC) previously treated with chemotherapy.

Methods: A two-stage accrual design was used to ensure detection of a true response rate of at least 20% with a type I error of .04.

Selecting respirators for control of worker exposure to infectious aerosols.

A method for selecting respirators for protection in infectious aerosol environments was developed, building on a procedure used to choose respiratory protection for environments containing nonbiological contaminants. Modifications in the traditional respirator selection method are proposed for situations where information on occupational exposure limits, toxicity, and airborne concentrations is absent. Toxicity is determined from risk rankings proposed by a variety of organizations.

Improved methods for generation, sampling, and recovery of biological aerosols in filter challenge tests.

In preparation for filter efficiency tests and sampler comparison studies, methods of biological aerosol generation, sampling, and filter recovery were modified from previous studies. Methods described include (1) techniques for generating aerosols that reduced nuisance particles to negligible levels and increased the cell culturability of Mycobacterium abscessus by 30%, (2) sampling techniques that lowered the detectable range of biological particle size from 0.65 to 0.

Collection of three bacterial aerosols by respirator and surgical mask filters under varying conditions of flow and relative humidity.

A variety of respirator filters and surgical masks were challenged with three aerosolized bacteria: Mycobacterium abscessus (M.a.) (a rod), Staphylococcus epidermidis (S.

The amiloride resistance gene, car1, of Schizosaccharomyces pombe.

Amiloride, an inhibitor of various sodium transporters, is toxic to Schizosaccharomyces pombe at low concentration in minimal but not in rich media. Amiloride-resistant mutants were isolated and shown to represent a new locus (car1 for changed amiloride resistance) on chromosome I. The car1 gene was cloned and sequenced.

Gene amplification at a locus encoding a putative Na+/H+ antiporter confers sodium and lithium tolerance in fission yeast.

We have identified a new locus, sodium 2 (sod2) based on selection for increased LiCl tolerance in fission yeast, Schizosaccharomyces pombe. Tolerant strains have enhanced pH-dependent Na+ export capacity and sodium transport experiments suggest that the gene encodes an Na+/H+ antiport. The predicted sod2 gene product can be placed in the broad class of transporters which possess 12 hydrophobic transmembrane domains.