STUDIES ON THE ETIOLOGY OF SNUFFLES IN STOCK RABBITS : PARANASAL SINUSITIS A FACTOR IN THE INTERPRETATION OF EXPERIMENTAL RESULTS.

In our experience, covering a large number of rabbits, we have found that the condition known as snuffles falls into different types, the acute and fatal, symptomatic of some underlying infection such as septicemia or pneumonia; and the intermittent, and the chronic. The intermittent and the chronic types considered in this paper are those most commonly present in laboratory stocks. Our observations point to a widespread prevalence of the disease among rabbits kept under laboratory conditions.

STUDIES ON THE NASOPHARYNGEAL SECRETIONS FROM PATIENTS WITH COMMON COLDS.

From the foregoing experiments it appears that with the filtered nasopharyngeal secretions from early cases of typical infections common colds in the first 3 to 18 hours of the disease, a similar condition can be transmitted to man. With the unheated but not with the heated secretions from four of six such patients we have succeeded in transmitting an affection indistinguishable from common cold to four men and in two instances the condition was conveyed from the person with the experimental disease to a second individual -in all, therefore, to six supposedly normal subjects. The periods of incubation in the experimental disease varied from 8 to 48 hours.

SEPARATION OF THE TOXINS OF BACILLUS DYSENTERIAE SHIGA.

By the suppression, through anaerobiosis, of the exotoxin-producing activity of Bacillus dysenteriae Shiga a pure endotoxin is produced directly from the culture. The duality of the poison of Shiga bacillus is further substantiated by studies on the diffusion of exotoxin, or neurotoxin, and endotoxin, or enterotoxin, by means of collodion sacs, implanted intraabdominally in rabbits or placed in vitro.