Publications by authors named "McCambridge A"

Background: StrokeLine is a stroke-specific helpline used by stroke survivors and their families in Australia to access professional support. There has been little research exploring stroke survivors' experiences of using helplines and their perceived impact on their stroke recovery.

Aim: The aim of this study is to explore the reasons prompting stroke survivors to call StrokeLine and their experiences and to describe the perceived impact of calling StrokeLine on their recovery.

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Pulmonary artery pseudoaneurysms (PAPs) are rare and life-threatening occurrences. We present a 57-year-old male patient with squamous cell lung cancer, who presented with hemoptysis. Bronchoscopy did not reveal ongoing bleeding.

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Isolated cervical dystonia is a focal, idiopathic dystonia affecting the neck muscles. Treatment usually consists of botulinum neurotoxin (BoNT) injections into the dystonic muscles. Our aim is to investigate the use of BoNT treatment and conservative treatments by people living with cervical dystonia.

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Background: StrokeLine is a specialised telephone helpline led by health professionals in Australia.

Aims: (i) To describe the profile of StrokeLine callers; (ii) to understand the reasons people engage with the service and (iii) how StrokeLine responded to the caller's needs.

Methods: Routine call data were obtained from the StrokeLine between November 2019 and November 2020.

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Article Synopsis
  • Me31B/DDX6 is an RNA helicase involved in regulating RNA after it's transcribed, with different roles in various cell types and organisms.
  • The study focuses on Drosophila (fruit flies), using CRISPR to mutate key parts of Me31B, including its helicase and other domains, to understand their functions.
  • Results show that these mutated motifs are essential for functions in fertility and germline development, revealing how Me31B operates within the cell.
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Objective: To systematically search the internet for conservative rehabilitation protocols for people with an anterior cruciate ligament (ACL) injury and critically appraise the websites and exercise protocols.

Design: Systematic review of online rehabilitation protocols.

Search: We searched four online search-engines (Google, Yahoo, Bing, DuckDuckGo).

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The current health reforms in Aotearoa New Zealand are being described as "transformational". Political leaders and Crown officials maintain the reforms embed a commitment to Te Tiriti o Waitangi, address racism and promote health equity. These claims are familiar and have been used to socialise previous health sector reforms.

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Purpose: Dystonia is a neurological disorder characterised by involuntary muscle contractions. Pain is the primary non-motor symptom, and limited studies have investigated how dystonic pain is experienced. This study aimed to investigate how people with isolated dystonia describe their pain and compare across subgroups of dystonia.

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Background: Cervical dystonia (CD) is an isolated, focal, idiopathic dystonia affecting the neck and upper back. CD is usually treated by botulinum neurotoxin (BoNT) injections into the dystonic muscles; however, about 20% of people will discontinue BoNT therapy. This systematic review aimed to determine the barriers to satisfaction and facilitators that could improve satisfaction with BoNT therapy for people with CD.

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Article Synopsis
  • - The study examines the differences in reporting statistical data, specifically p values, effect estimates, and clinical relevance, in physiotherapy randomized controlled trials (RCTs) from the years 2000 and 2018.
  • - Researchers analyzed 140 RCTs from major physiotherapy journals, finding that while the reporting of p values remained consistently high (>90%), there was a significant increase in the reporting of effect estimates (up 26.6%), confidence intervals (up 34%), and clinical relevance (up 32.8%) from 2000 to 2018.
  • - Despite improvements in the reporting of statistical data, over 40% of the RCTs in 2018 still did not adequately
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Objectives: To investigate the completeness of reporting of physical therapy interventions in randomized controlled trials before and after publication of the Template for Intervention Description and Replication (TIDieR) checklist (a reporting guideline for interventions).

Design: Meta-research.

Methods: We searched 6 journals for trials using physical therapy interventions that were published in 2000 and 2018.

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Cervical dystonia (CD) is a neurological movement disorder causing the neck to move involuntarily away from the neutral position. CD is a network disorder, involving multiple brain areas and, therefore, may impair movement in parts of the body other than the neck. This study used clinical assessments to investigate walking, balance and upper limb function (UL) in people with CD; the reliability of scoring these assessments and examined for relationship between CD severity, usual exercise and clinical assessments.

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New treatments that can facilitate neural repair and reduce persistent impairments have significant value in promoting recovery following stroke. One technique that has gained interest is transcranial direct current stimulation (tDCS) as early research suggested it could enhance plasticity and enable greater behavioral recovery. However, several studies have now identified substantial intersubject variability in response to tDCS and clinical trials revealed insufficient evidence of treatment effectiveness.

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Article Synopsis
  • - The study aimed to validate recent prognostic models that predict the ability to walk independently after a stroke using accessible predictors.
  • - Researchers identified three relevant models, but only the Australian model was validated with a cohort of 957 stroke patients, showing good performance metrics such as an Area Under the Curve (AUC) of 0.77.
  • - By adjusting the model and including paretic leg strength, the predictive performance improved, achieving an AUC of 0.82, indicating better accuracy in predicting independent gait.
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Rehabilitation for isolated forms of dystonia, such as cervical or focal hand dystonia, is usually targeted towards the affected body part and focuses on sensorimotor control and motor retraining of affected muscles. Recent evidence, has revealed people who live with dystonia experience a range of functional and non-motor deficits that reduce engagement in daily activities and health-related quality of life, which should be addressed with therapeutic interventions. These findings support the need for a holistic approach to the rehabilitation of dystonia, where assessment and treatments involve non-motor signs and symptoms, and not just the dystonic body part.

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Transcranial magnetic stimulation (TMS) is a non-invasive method to assess neurophysiology of the primary motor cortex in humans. Dystonia is a poorly understood neurological movement disorder, often presenting in an idiopathic, isolated form across different parts of the body. The neurophysiological profile of isolated dystonia compared to healthy adults remains unclear.

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Transcranial magnetic stimulation (TMS) produces motor-evoked potentials (MEP) used to infer changes in corticomotor excitability. In humans, neck rotation can probe reticulospinal input on corticomotor output. This study investigated the effect of neck rotation on MEP duration in a proximal and distal upper limb muscle and compared responses between rest and preactivation.

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Me31B is a protein component of Drosophila germ granules and plays an important role in germline development by interacting with other proteins and RNAs. To understand the dynamic changes that the Me31B interactome undergoes from oogenesis to early embryogenesis, we characterized the early embryo Me31B interactome and compared it to the known ovary interactome. The two interactomes shared RNA regulation proteins, glycolytic enzymes, and cytoskeleton/motor proteins, but the core germ plasm proteins Vas, Tud, and Aub were significantly decreased in the embryo interactome.

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Dystonia is a neurological movement disorder that presents as sustained or intermittent involuntary muscle contractions causing abnormal postures and movements. Knowledge of dystonia is mostly at the impairment level with minimal understanding of activity and participation limitations. Physical activity (PA) is an important aspect of neurological disease management, with wide-ranging benefits for overall health and quality of life.

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