An 18-Year Review of Hemoglobinopathy Proficiency Testing: Recommendations From the College of American Pathologists Hematology and Clinical Microscopy Committee.

Context.—: The College of American Pathologists Hematology and Clinical Microscopy Committee implemented a hemoglobinopathy proficiency testing and education program to monitor and assess the performance of participating laboratories.

Objective.

Emotional inertia is independently associated with cognitive emotion regulation strategies and sleep quality.

Emotional inertia (i.e. the tendency for emotions to persist over time) is robustly associated with lower wellbeing.

Sociocultural and masculinity influences on colorectal cancer screening participation among Hispanic/Latino men in Florida, New York, and Texas.

Background: This cross-sectional study explored how masculinity beliefs may influence colorectal cancer (CRC) screening participation among ethnic subgroups of screening-age-eligible (45-75 years) Hispanic/Latino men.

Methods: Using a consumer panel, we recruited self-identified Hispanic/Latino men fluent in English or Spanish, and residing in Florida, New York, or Texas. The Masculinity Barriers to Medical Care (MBMC) scale and its six subscales were used to assess masculinity beliefs.

Effect of an Inflatable Colon on Colorectal Cancer Knowledge and Screening Intent Among Male Attendees at State Fairs in Two Midwestern States, 2023.

Introduction: Colorectal cancer (CRC) is the third most-diagnosed cancer among men and women in the US. This study aimed to evaluate the influence of an interactive inflatable colon exhibit on CRC knowledge and screening intent among men attending state fairs in 2 midwestern states.

Methods: At the 2023 state fairs in 2 midwestern states, eligible participants (men aged 18-75 y who could speak and read English and resided in 1 of the 2 states) completed a presurvey, an unguided tour of the inflatable Super Colon, and a postsurvey.

Understanding the experiences of transition for newly qualified mental health nurses and their potential to stay in the role: A qualitative exploration.

Aim: To understand the experiences of transition from the perspective of newly qualified mental health nurses and the impact this may have on their potential to remain in the role.

Background: During the transitional period following registration newly qualified nurses experience feelings of being overwhelmed and shock. Internationally there is limited research on factors influencing transitional experiences in the field of mental health.

Expression of CD6 in Aggressive NK/T-cell Neoplasms and Assessment as a Potential Therapeutic Target: A Bone Marrow Pathology Group Study.

Background: Aggressive NK/T-Cell neoplasms are rare hematological malignancies characterized by the abnormal proliferation of NK or NK-like T (NK/T) cells. CD6 is a transmembrane signal transducing receptor involved in lymphocyte activation and differentiation. This study aimed to investigate the CD6 expression in these malignancies and explore the potential of targeting CD6 in these diseases.

"Let's talk about it": Black youths' perceptions on the development of a school-based social media campaign.

The increase in social media mental health (MH) campaigns provides an opportunity to improve awareness and attitudes toward MH. However, racial disparities remain in these social media campaigns. Black youth who participated in MH social media campaigns reported lower levels of improvement in stigma and help-seeking than their White peers.

Breast cancer exploits neural signaling pathways for bone-to-meninges metastasis.

The molecular mechanisms that regulate breast cancer cell (BCC) metastasis and proliferation within the leptomeninges (LM) are poorly understood, which limits the development of effective therapies. In this work, we show that BCCs in mice can invade the LM by abluminal migration along blood vessels that connect vertebral or calvarial bone marrow and meninges, bypassing the blood-brain barrier. This process is dependent on BCC engagement with vascular basement membrane laminin through expression of the neuronal pathfinding molecule integrin α6.

An appraisal-based chain-of-emotion architecture for affective language model game agents.

The development of believable, natural, and interactive digital artificial agents is a field of growing interest. Theoretical uncertainties and technical barriers present considerable challenges to the field, particularly with regards to developing agents that effectively simulate human emotions. Large language models (LLMs) might address these issues by tapping common patterns in situational appraisal.

Temporal associations of plasma levels of the secreted phospholipase A family and mortality in severe COVID-19.

Previous research suggests that group IIA-secreted phospholipase A (sPLA-IIA) plays a role in and predicts lethal COVID-19 disease. The current study reanalyzed a longitudinal proteomic data set to determine the temporal relationship between levels of several members of a family of sPLA isoforms and the severity of COVID-19 in 214 ICU patients. The levels of six secreted PLA isoforms, sPLA-IIA, sPLA-V, sPLA-X, sPLA-IB, sPLA-IIC, and sPLA-XVI, increased over the first 7 ICU days in those who succumbed to the disease but attenuated over the same time period in survivors.

The relationship between environmentally induced emotion and memory for a naturalistic virtual experience.

Emotional stimuli (e.g. words, images) are often remembered better than neutral stimuli.

First impressions from faces in dynamic approach-avoidance contexts.

Theoretical understanding of first impressions from faces has been closely associated with the proposal that rapid approach-avoidance decisions are needed during social interactions. Nevertheless, experimental work has rarely examined first impressions of people who are actually moving-instead extrapolating from photographic images. In six experiments, we describe the relationship between social attributions (dominance and trustworthiness) and the motion and apparent intent of a perceived person.

Diagnosis change in pediatric inflammatory bowel disease.

Objectives: This study aims to characterize pediatric inflammatory bowel disease (IBD) patients who change diagnosis and describe the characteristics of that change.

Methods: A retrospective study was conducted on pediatric IBD patients from the ImproveCareNow (ICN) multicenter international cohort from 2007 to January 2019. Primary outcome was change in diagnosis after the first four visits.

Improved resolution in fiber bundle inline holographic microscopy using multiple illumination sources.

Recent work has shown that high-quality inline holographic microscopy images can be captured through fiber imaging bundles. Speckle patterns arising from modal interference within the bundle cores can be minimized by use of a partially-coherent optical source such as an LED delivered via a multimode fiber. This allows numerical refocusing of holograms from samples at working distances of up to approximately 1 mm from the fiber bundle before the finite coherence begins to degrade the lateral resolution.

Impact of Weekday on Short-term Surgical Outcomes After Lumbar Fusion Surgery.

Study Design: Retrospective cohort study.

Objective: The purpose of this study is to investigate whether weekday lumbar spine fusion surgery has an impact on surgical and inpatient physical therapy (PT) outcomes.

Summary Of Background Data: Timing of surgery has been implicated as a factor that may impact outcomes after spine surgery.

Development and Validation of a Prostate Biopsy Risk Calculator in Black Men.

Purpose: We sought to develop and validate a prostate biopsy risk calculator for Black men and compare it with the Prostate Cancer Prevention Trial version 2.0, Prostate Biopsy Collaborative Group, and Kaiser Permanente Prostate Cancer Risk Calculators for the detection of Gleason Grade Group (GG) ≥ 2 prostate cancer (PCa).

Materials And Methods: We prospectively recruited 2 cohorts of men undergoing prostate biopsy from 5 facilities in Chicago.

Attritional Extensor Digiti Minimi Tendon Rupture Associated With a Distal Ulna Fracture.

Attritional extensor tendon ruptures are common in the setting of arthritis but, to our knowledge, have never previously been reported in the setting of a distal ulna fracture. This case report describes a 56-year-old male patient who sustained a left-hand dog bite resulting in crush injuries to the thumb and ring finger and a minimally displaced distal ulna fracture. The patient initially underwent appropriate surgical intervention for the thumb and finger crush injuries and non-operative management of the distal ulna fracture with splint immobilization.