Otitis interna as a result of Pasteurella multocida infection in a laboratory woodchuck.

A laboratory woodchuck presented clinically with left-sided torticollis and a purulent exudate within the external auditory meatus of the left ear. Bacterial culture of the exudate resulted in a heavy growth of Pasteurella multocida. Treatment was initiated with topical and systemic antimicrobial compounds.

Adenosine-uridine binding factor requires metals for binding to granulocyte-macrophage colony-stimulating factor mRNA.

Post-transcriptional gene regulation plays an important role in the expression of granulocyte-macrophage colony-stimulating factor (GM-CSF). Cytokine secretion by activated lymphocytes or mast cells is preceded by dramatic stabilization of the normally labile GM-CSF mRNA. The 3'-untranslated region of GM-CSF and other labile mRNAs contain the destabilizing motif adenosine-uridine-uridine-uridine-adenosine (AUUUA).

Immune complex glomerulopathy in a child with food hypersensitivity.

This report describes the occurrence of immune complex glomerulonephritis in a patient with eosinophilic gastroenteritis and food hypersensitivity. A coincident allergen injection may have been a contributing factor in the sudden development of the nephrotic syndrome. Markedly elevated levels of circulating immune complexes (greater than 6400 mg/dl) were found containing kappa-casein and bovine serum albumin (BSA), the latter predominating.

Cellular and humoral mechanisms in the pathogenesis of tubulointerstitial nephritis.

Brown-Norway (BN) rats immunized with renal medulla from Sprague-Dawley (SD) rats developed a renal lesion characterized by focal interstitial and perivascular mononuclear cell infiltrates without glomerular involvement. The cellular infiltrates were extracted from the affected kidneys and determined to consist of monocytes 64 +/- 4% (mean +/- S.D.

Sympathetic nervous system and exercise tolerance response in normotensive and hypertensive adolescents.

Comparative evaluation of isometric and dynamic exercise performance in normotensive, borderline hypertensive and hypertensive adolescents was made. Hemodynamic changes were correlated with level of adrenergic sympathetic nervous system activity as measured by plasma epinephrine and norepinephrine values. No significant intergroup differences were found with respect to isometric exercise with the exception of high peak isometric exercise heart rates and plasma epinephrine levels in the patients with significant hypertension.

Blood pressure, heart rate, and plasma catecholamines in normal and hypertensive children and their siblings at rest and after standing.

Heart rate, systolic blood pressure (SBP), diastolic blood pressure (DBP), plasma norepinephrine (NE), and epinephrine (E) levels at rest and in response to orthostatic stress of quiet standing were compared in 19 subjects with borderline hypertension (BH) (SBP-135 mm Hg, DBP-80 mm Hg), nine with significant hypertension (SH) (SBP-150 mm Hg, DBP-95 mm Hg), 14 normotensive siblings (NS) of hypertensives (SBP-113 mm Hg, DBP-64 mm Hg), and 21 age-matched normotensive controls (NC) (SBP-116 mm Hg, DBP-61 mm Hg). Group resting plasma NE levels were significantly higher in BH (454 pg/ml, p less than 0.001 pg/ml) and SH (384 pg/ml, p less than 0.

Regulation of renal functional development.

An explanation of the functional development of the renal system is offered, with particular emphasis on glomerular fitration, renal vascular resistance, the development of the renal tubules, and quantitative measurement of renal obstruction.

Safety of intravenous diazoxide in children with severe hypertension.

The safety and efficacy of diazoxide administered intravenously in the treatment of children with acute severe hypertension have been evaluated by a collaborative study. Observations of the response of blood pressure in 36 patients, ranging in age from two months to 18 years, during the initial episode of hospitalization reveal diazoxide treatment to be effective in lowering blood pressure in 94 per cent of the cases. No serious adverse circulatory, fluid and electrolyte, metabolic or hematologic effects were observed.

Recent trends in the mortality rate from renal disease in children and young adults in New York City.

Analysis has shown that the over-all death rate from renal disease for residents of New York City under 25 years of age has declined from 4.6 per 100,000 in 1950 to 2.3 per 100,000 in 1970.

The normal embryologic development of the kidney: a basis for understanding structural abnormalities.

The embryologic development of the metanephric kidney is a regulated and sequential growth process. The induction of the early precursors of the metanephric kidney (pronephros and mesonephric) are essential first steps for the later appearance of the metanephric kidney. The pathogenesis of cystic disease can now be reexamined in light of these unique but carefully programmed growth processes with the expectation that the specific nature of the several growth disorders responsible can be more clearly defined.